We aimed to evaluate cardiac function by trans-epicardial echocardiography in a pioneering ovine model of severe cardiopulmonary failure (CPF). Six healthy female sheep (weight 6166.5 kg) were anes- thetized, tracheally intubated and mechanically ventilated. An arterial catheter was placed for blood sampling and pressure monitoring. Left femoral artery and right jugular vein were cannulated and veno-arterial extracorporeal membrane oxygenation support commenced at a rate of 1.5760.60 L/min. A left mini-thoracotomy was performed to access the pericardial sac. Heart failure was developed through intra-myocardial ethanol injections in the lef ventricle. Ventilatory support was substantially decreased to concomitantly develop pulmonary failure. Cardiac function pre and post-development of CPF was evaluated by trans- epicardial echocardiography (Philips IE-33, North Ryde, Australia) and analysed by dedicated software (TOMTEC Imaging Systems GmbH, Germany). CPF caused a drop in mean arterial pressure and oxygenation, which resulted in an upsurge of lactate. Corresponding with a drop of mean arterial pressure, LV systolic function including left ventricular (LV) fractional area change, global circumfer- ential strain and global radial strain also significantly decreased. In an innovative animal model of CPF, epicardial echocar- diography is a reliable and feasible mean to follow-up dy- namics of cardiac dysfunction.
Epicardial Echocardiography in a Novel Ovine Model of Cardiopulmonary Failure / K. Sato, S. Heinsar, S. Rozencwajg, S. Colombo, K. Wildi, J. Jung, C. Ainola, X. Wang, G. Abbate, N. Sato, J. Reid, M. Bouquet, V. Lo Cocco, E. Wood, J. Suen, A. Combes, R. Lorusso, A. Pesenti, G. Li Bassi, J. Chan, J. Fraser. - In: HEART LUNG & CIRCULATION. - ISSN 1443-9506. - 29:Supplement 2(2020), pp. 111.S85-111.S86. (Intervento presentato al 68. convegno Cardiac Society of Australia and New Zealand Annual Scientific Meeting, the International Society for Heart Research Australasian Section Annual Scientific Meeting and the 14th Annual Australia and New Zealand Endovascular Therapies Meeting, 11–13 December 2020 nel 2020) [10.1016/j.hlc.2020.09.118].
Epicardial Echocardiography in a Novel Ovine Model of Cardiopulmonary Failure
S. Colombo;G. Li Bassi;
2020
Abstract
We aimed to evaluate cardiac function by trans-epicardial echocardiography in a pioneering ovine model of severe cardiopulmonary failure (CPF). Six healthy female sheep (weight 6166.5 kg) were anes- thetized, tracheally intubated and mechanically ventilated. An arterial catheter was placed for blood sampling and pressure monitoring. Left femoral artery and right jugular vein were cannulated and veno-arterial extracorporeal membrane oxygenation support commenced at a rate of 1.5760.60 L/min. A left mini-thoracotomy was performed to access the pericardial sac. Heart failure was developed through intra-myocardial ethanol injections in the lef ventricle. Ventilatory support was substantially decreased to concomitantly develop pulmonary failure. Cardiac function pre and post-development of CPF was evaluated by trans- epicardial echocardiography (Philips IE-33, North Ryde, Australia) and analysed by dedicated software (TOMTEC Imaging Systems GmbH, Germany). CPF caused a drop in mean arterial pressure and oxygenation, which resulted in an upsurge of lactate. Corresponding with a drop of mean arterial pressure, LV systolic function including left ventricular (LV) fractional area change, global circumfer- ential strain and global radial strain also significantly decreased. In an innovative animal model of CPF, epicardial echocar- diography is a reliable and feasible mean to follow-up dy- namics of cardiac dysfunction.
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