Epidemiology and outcomes of early-onset AKI in COVID-19-related ARDS in comparison with non-COVID-19-related ARDS: insights from two prospective global cohort studies

Mcnicholas, B.A.; Rezoagli, E.; Simpkin, A.J.; Khanna, S.; Suen, J.Y.; Yeung, P.; Brodie, D.; Bassi, G.L.; Pham, T.; Bellani, G.; Fraser, J.F.; Laffey, J.; Cccc, C.; Al-Dabbous, T.; Alfoudri, H.; Shamsah, M.; Alhadad, Q.; Hanan, M.; Elapavaluru, S.; Berg, A.; Horn, C.; Ahmed Reda Mohamed Elsayed Abdelhalim,; Amro Essam Amer,; Cinderella Omar Rageh Elnaggar,; Ahmed Ayman Hassan,; Abdelaziz, A.; Abdelhalim, M.; Yehia Samir Shaaban Aly Orabi,; Alaraji, Z.A.; Muhaisen, M.R.; Almasri, L.; Mustafa, D.; Hamdan, S.; Al-Saba’a, Y.; Dalloul, Z.; Alkahlout, M.; Jaber, H.; Aldabbourosama, O.; Mohamed Hussein, A.A.R.; Zarief Kamel Emad,; Khaled, S.; Mohamed, N.; Hassanin, E.; Hamdi, A.; Ragab, A.; Azizeldin, M.G.; Mayasi, Y.; Schroll, S.; Meyer, D.; Velazco, J.; Ploskanych, L.; Fikes, W.; Bagewadi, R.; Dao, M.; White, H.; Alondra Berrios Laviena,; Ehlers, A.; Shalabi-McGuire, M.; Witt, T.; Grazioli, L.; Lorini, L.; Wilson Grandin, E.; Nunez, J.; Reyes, T.; O’Briain, D.; Hunter, S.; Ramanan, M.; Affleck, J.; Hemanth Hurkadli Veerendra,; Rai, S.; Russell-Brown, J.; Nourse, M.; Joseph, M.; Mitchell, B.; Tenzer, M.; Abe, R.; Hwa Jin Cho,; In Seok Jeong,; Rahman, N.; Kakar, V.; Sun, H.; Hanley, A.; Brozzi, N.; Mehkri, O.; Krishnan, S.; Duggal, A.; Houltham, S.; Graf, J.; Diaz, R.; Orrego, R.; Delgado, C.; González, J.; Maria Soledad Sanchez,; Piagnerelli, M.; Josefa Valenzuela Sarrazin,; Zabert, G.; Espinosa, L.; Delgado, P.; Delgado, V.; Diego Fernando Bautista Rincón,; Angela Maria Marulanda Yanten,; Melissa Bustamante Duque,; Brodie, D.; Abouelmagd, K.; Elhazmi, A.; Al-Hudaib, A.; Javidfar, J.; Callahan, M.; Dong, A.; Charles Crepy D’Orleans,; Azhari Taufik, M.; Elizabeth Yasmin Wardoyo,; Gunawan, M.; Trisnaningrum, N.S.; Irawany, V.; Rayhan, M.; Panigada, M.; Pesenti, A.; Zanella, A.; Grasselli, G.; Colombo, S.; Martinet, C.; Florio, G.; Antonelli, M.; Carelli, S.; Grieco, D.L.; Asaki, M.; Hoshino, K.; Salazar, L.; Mary Alejandra Mendoza Monsalve,; Laffey, J.; Mcnicholas, B.; Cosgrave, D.; Atif, M.; Qutishat, F.; Laffey, C.; Michaeala Van Der Walt,; Mccaffrey, J.; Bone, A.; Hakeem, Y.; Winearls, J.; Tallott, M.; Thomson, D.; Joubert, I.; Arnold-Day, C.; Piercy, J.; Richard Van Zyl Smit,; Miller, M.; Seymour, L.; Francois Van Heyningen,; Teyangesikayi, G.; Fredericks, D.; Ali Ait Hssain,; Aliudin, J.; Alqahtani, A.; Mohamed, K.; Mohamed, A.; Tan, D.; Villanueva, J.; Zaqout, A.; Kurtzman, E.; Ademi, A.; Dobrita, A.; Khadija El Aoudi,; Segura, J.; Giwangkancana, G.; Ohshimo, S.; Osatnik, J.; Joosten, A.; Torres, A.; Yang, M.; Motos, A.; Luna, C.; Arancibia, F.; Williams, V.; Noel, A.; Luque, N.; Fantini, M.; Ruth Noemi Jorge García,; Enrique Chicote Alvarez,; Greti, A.; Ceccato, A.; Sanchez, A.; Ana Loza Vazquez,; Roche-Campo, F.; Franch-Llasat, D.; Tuazon, D.; Amato, M.; Cassimiro, L.; Pola, F.; Ribeiro, F.; Fonseca, G.; Dalton, H.; Desai, M.; Osborn, E.; Deeb, H.; Arcadipane, A.; Martucci, G.; Panarello, G.; Vitiello, S.; Bianco, C.; Occhipinti, G.; Rossetti, M.; Cuffaro, R.; Cho, S.; Whitman, G.; Marwan El Sayed,; Mokhtar, W.; El-Shenawy, E.; Shimizu, H.; Moriyama, N.; Kim, J.; Kitamura, N.; Gebauer, J.; Yokoyama, T.; Al-Fares, A.; Buabbas, S.; Alamad, E.; Alawadhi, F.; Alawadi, K.; Mohamed Ahmed Khalefa,; Nourah Ahmad Abdulaziz Al Ajeel,; Mohammad Fathy Aly,; Al-Saleh, A.; Naanouh, A.; Alaa Mohammed Elshourbgy,; Al-Fares, A.; Mohamed Yousef Gad,; Rania Mohamed Elrazaz,; Khadadah, I.; Ahmed Mohammed Almumin,; Altarakma, H.; Albannay, H.; Mohammed Kh Alsaleh,; Mahmoud Saad Abdallah Radwan,; Islam Ahmed Saadallah,; Tanaka, H.; Hashimoto, S.; Yamazaki, M.; Tak-Hyuck, O.; Epler, M.; Forney, C.; Kruse, L.; Feister, J.; Williamson, J.; Grobengieser, K.; Gnall, E.; Golden, S.; Caroline, M.; Shapiro, T.; Karaj, C.; Thome, L.; Sher, L.; Vanderland, M.; Welch, M.; Mcdermott, S.; Brain, M.; Mineall, S.; Unwin, M.; Chen, L.; Trezise, T.; Mckeon, L.; Kimura, D.; Brazzi, L.; Sales, G.; Montrucchio, G.; Ogston, T.; Nagpal, D.; Fischer, K.; Lorusso, R.; Bas Van Bussell,; Maria Elena De Piero,; Mariani, S.; Rangappa, R.; Rajesh Mohan Shetty,; Sujin Rai, P.; Ganesan, A.; Esperatti, M.; Nora Angélica Fuentes,; Maria Eugenia Gonzalez,; O’Briain, D.; Carton, E.G.; Sen, A.; Palacios, A.; Rainey, D.; Samoukoviv, G.; Campisi, J.; Durham, L.; Neumann, E.; Seefeldt, C.; Falcucci, O.; Emmrich, A.; Guy, J.; Johns, C.; Potzner, K.; Zimmermann, C.; Espinal, A.; Buchtele, N.; Schwameis, M.; Korhnfehl, A.; Brock, R.; Staudinger, T.; Stecher, S.; Barnikel, M.; Antón, S.; Pawlikowski, A.; Zaaqoq, A.; Lan Anh Galloway,; Merley, C.; Nichol, A.; Csete, M.; Quesada, L.; Saba, I.; Kasugai, D.; Hiraiwa, H.; Tanaka, T.; Marwali, E.; Purnama, Y.; Santi Rahayu Dewayanti,; Ardiyan,; Dafsah Arifa Juzar,; Siagian, D.; Chen, Y.; Ogino, M.; Nasa, P.; Matthew, C.; Nimisha Abdul Majeed,; Ratsep, I.; Post, A.; Sillaots, P.; Krund, A.; Lehiste, M.; Lepik, T.; Manetta, F.; Mihelis, E.; Iam Claire Sarmiento,; Narasimhan, M.; Varrone, M.; Komats, M.; Garcia-Diaz, J.; Harmon, C.; Veena Satyapriya, S.; Bhatt, A.; Mokadam, N.A.; Uribe, A.; Gonzalez, A.; Shi, H.; Mckeown, J.; Pasek, J.; Fiorda, J.; Echeverria, M.; Moreno, R.; Zakhary, B.; Cavana, M.; Cucino, A.; Foti, G.; Giani, M.; Fumagalli, B.; Chiumello, D.; Castagna, V.; Dell’Amore, A.; Navalesi, P.; Shum, H.; Vuysteke, A.; Usman, A.; Acker, A.; Smood, B.; Mergler, B.; Sertic, F.; Subramanian, M.; Sperry, A.; Rizer, N.; Burhan, E.; Rasmin, M.; Akmal, E.; Sitompul, F.; Lolong, N.; Naivedh, B.; Erickson, S.; Barrett, P.; Dean, D.; Daugherty, J.; Loforte, A.; Khan, I.; Mohammed Abraar Quraishi,; Desantis, O.; Dominic, S.; Kandamby, D.; Mandei, J.M.; Natanael, H.; Yudhalantang, E.; Lantang, A.; Surya Oto Wijaya,; Jung, A.; George, N.; Wing Yiu Ng,; Pauline Yeung Ng,; Fang, S.; Tabah, A.; Ratcliffe, M.; Duroux, M.; Alajeeli, A.; Tarhabat, A.; Adachi, S.; Nakao, S.; Blanco, P.; Prieto, A.; Sánchez, J.; Nicholson, M.; Butt, W.; Serratore, A.; Delzoppo, C.; Janin, P.; Yarad, E.; Totaro, R.; Coles, J.; Pujo, B.; Balk, R.; Vissing, A.; Kapania, E.; Hays, J.; Fox, S.; Yantosh, G.; Mishin, P.; Yuliarto, S.; Kohar Hari Santoso,; Djajalaksana, S.; Arie Zainul Fatoni,; Fukuda, M.; Liu, K.; Pelosi, P.; Battaglini, D.; Juan Fernando Masa Jiménez,; Bastos, D.; Gaião, S.; Rusmawatiningtyas, D.; Cho, Y.; Su Hwan Lee,; Kawasaki, T.; Munshi, L.; Sakiyalak, P.; Nitayavardhana, P.; Mohamed Bashir Elagili,; Talat Ahmed Abu Salem,; Seitz, T.; Arora, R.; Kent, D.; Marino, D.; Parwar, S.; Cheng, A.; Miller, J.; Fujitani, S.; Shimizu, N.; Madhok, J.; Owyang, C.; Buscher, H.; Reynolds, C.; Maasikas, O.; Aleksanbeljantsev,; Mihnovits, V.; Akimoto, T.; Aizawa, M.; Horibe, K.; Onodera, R.; Hodgson, C.; Burrell, A.; Young, M.; George, T.; Shekar, K.; Mcguinness, N.; Irvine, L.; Flynn, B.; Endo, T.; Sugiyama, K.; Shimizu, K.; Fan, E.; Exconde, K.; Ichiba, S.; Binnawara, M.; Lussier, L.; Lotz, G.; Malfertheiner, M.; Maier, L.; Dreier, E.; Neurinda Permata Kusumastuti,; Mccloskey, C.; Dabaliz, A.; Elshazly, T.B.; Smith, J.; Szuldrzynski, K.S.; Bielański, P.; Hakeem, Y.; Wille, K.; Murthy, S.; Parhar, K.K.S.; Fiest, K.M.; Codan, C.; Shahid, A.; Fayed, M.; Evans, T.; Garcia, R.; Gutierrez, A.; Shimizu, H.; Song, T.; Rose, R.; Bennett, S.; Richardson, D.; Peek, G.; Arora, L.; Rappapport, K.; Rudolph, K.; Sibenaller, Z.; Stout, L.; Walter, A.; Herr, D.; Vedadi, N.; Bartlett, R.; Pesenti, A.; Thompson, S.; Hoffman, J.; Ying, X.; Williams, B.; Sanchez, E.; Akwani, C.; Kennedy, R.; Elhadi, M.; Griffee, M.; Mone, M.; Ciullo, A.; Kida, Y.; Ricard Ferrer Roca,; Riera, J.; Contreras, S.; Alegre, C.; Kay, C.; Fischer, I.; Renner, E.; Taniguci, H.; Lee, J.; Plotkin, D.; Barbara Wanjiru Citarella,; Merson, L.; Hartley, E.; Lubis, B.; Ikeyama, T.; Alhamad, A.; Fathi, M.; Mohammed Maher Hadhoud,; Alhouri, H.; Mechi, A.; Mohammed Saleh Alyasiri,; Muhammed Zainab Alghali Elsaid,; Shahla, H.; Bhaskar, B.; Jung, J.; Mcguinness, S.; Eastwood, G.; Sandra Rossi Marta,; Guarracino, F.; Gerle, S.; Coxon, E.; Claro, B.; Eleisawy, M.; Osama, H.; Loverde, D.; Patil, N.; Parrini, V.; Mcbride, A.; Negaard, K.; Ratsch, A.; Abdelaziz, A.; Juan David Uribe,; Peris, A.; Sanders, M.; Emerson, D.; Kamal, M.; Faida, H.; Povoa, P.; Francis, R.; Cherif, A.; Joseph, S.; Matteo Di Nardo,; Heard, M.; Kyle, K.; Blackwell, R.A.; Ouyahia, A.; Piagnerelli, M.; Biston, P.; Hye Won Jeong,; Smith, R.; Prawira, Y.; Montrucchio, G.; Arturo Huerta Garcia,; Salterain, N.; Meyns, B.; Elnasser, M.; Moreno, M.; Walia, R.; Mehta, A.; Schweda, A.; Williams, M.; Amkhatirah, E.; Kyung Hoon Kim,; Assad, A.; Giraldo, E.; Karolak, W.; Balik, M.; Pocock, E.; Mohamed, A.; Gajkowski, E.; Masafumi, K.; Barrett, N.; Takeyama, Y.; Park, S.; Amin, F.; Fina Meilyana Andriyani,; Sudakevych, S.; Schnur, J.; Ratsch, A.; Vera, M.; Cornejo, R.; Schwarz, P.; Ana Carolina Mardini,; Thais De Paula,; Ary Serpa Neto,; Villoldo, A.; Alexandre Siciliano Colafranceschi,; Alejandro Ubeda Iglesias,; Granjean, J.; Lívia Maria Garcia Melro,; Giovana Fioravante Romualdo,; Gaia, D.; Souza, H.; Galas, F.; Rafael Máñez Mendiluce,; Sosa, A.; Martinez, I.; Kurosawa, H.; Mohammad Badr Almoshantaf,; Salgado, J.; Hugi-Mayr, B.; Charbonneau, E.; Vitor Salvatore Barzilai,; Monteiro, V.; Rodrigo Ribeiro De Souza,; Harper, M.; Siddig, N.; Suzuki, H.; Adams, C.; Brieva, J.; Khamees, A.; Graige, F.; Supriatna, M.; Nyale, G.; Faisal Saleem Eltatar,; Fatani, J.; Baeissa, H.; Masri, A.A.L.; Rabie, A.; Mok Yee Hui,; Yamane, M.; Jung, H.; Ayorinde Mojisola Margaret,; Nacpil, N.; Ruck, K.; Bakken, R.; Jara, C.; Felton, T.; Tharwat, S.; Berra, L.; Shah, B.; Chakraborty, A.; Cardona, M.; Capatos, G.; Akkanti, B.; Orija, A.; Jain, H.; Ito, A.; Muftah, M.; Housni, B.; Aldhalia, A.; Low, S.; Iihara, K.; Chavez, J.; Ramanathan, K.; Zabert, G.; Naidoo, K.; Seppelt, I.; Vandyk, M.; Macdonald, S.; Ichiba, S.; Hafez, W.; Mcgregor, R.; Siebenaler, T.; Flynn, H.; Lofton, K.; Aokage, T.; Kvirkvelia, B.; Shigemitsu, K.; Moscatelli, A.; Fiorentino, G.; Baumgaertel, M.; Serge Eddy Mba,; Assy, J.; Hutahaean, A.; Roush, H.; Sichting, K.A.; Alessandri, F.; 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Stelfox, H.T.; Cassia, Y.; Elia, J.; Tribble, T.; Shankar, S.; Padmanabhan, R.; Hallinan, B.; Paoletti, L.; Leyva, Y.; Fykuda, T.; Badulak, J.; Koch, J.; Janowaik, L.; Hackman, A.; Hernandez, D.; Osofsky, J.; Donadello, K.; Lawang, A.; Fine, J.; Davidson, B.; Andres Oswaldo Razo Vazquez &amp;,; Abdehaleem, I.

doi:10.1186/S13054-023-04487-6

Background Acute kidney injury (AKI) is a frequent and severe complication of both COVID-19-related acute respiratory distress syndrome (ARDS) and non-COVID-19-related ARDS. The COVID-19 Critical Care Consortium (CCCC) has generated a global data set on the demographics, management and outcomes of critically ill COVID-19 patients. The LUNG-SAFE study was an international prospective cohort study of patients with severe respiratory failure, including ARDS, which pre-dated the pandemic. Methods The incidence, demographic profile, management and outcomes of early AKI in patients undergoing invasive mechanical ventilation for COVID-19-related ARDS were described and compared with AKI in a non-COVID-19-related ARDS cohort. Results Of 18,964 patients in the CCCC data set, 1699 patients with COVID-19-related ARDS required invasive ventilation and had relevant outcome data. Of these, 110 (6.5%) had stage 1, 94 (5.5%) had stage 2, 151 (8.9%) had stage 3 AKI, while 1214 (79.1%) had no AKI within 48 h of initiating invasive mechanical ventilation. Patients developing AKI were older and more likely to have hypertension or chronic cardiac disease. There were geo-economic differences in the incidence of AKI, with lower incidence of stage 3 AKI in European high-income countries and a higher incidence in patients from middle-income countries. Both 28-day and 90-day mortality risk was increased for patients with stage 2 (HR 2.00, p < 0.001) and stage 3 AKI (HR 1.95, p < 0.001). Compared to non-COVID-19 ARDS, the incidence of shock was reduced with lower cardiovascular SOFA score across all patient groups, while hospital mortality was worse in all groups [no AKI (30 vs 50%), Stage 1 (38 vs 58%), Stage 2 (56 vs 74%), and Stage 3 (52 vs 72%), p < 0.001]. The time profile of onset of AKI also differed, with 56% of all AKI occurring in the first 48 h in patients with COVID-19 ARDS compared to 89% in the non-COVID-19 ARDS population. Conclusion AKI is a common and serious complication of COVID-19, with a high mortality rate, which differs by geo-economic location. Important differences exist in the profile of AKI in COVID-19 versus non-COVID-19 ARDS in terms of their haemodynamic profile, time of onset and clinical outcomes.

Epidemiology and outcomes of early-onset AKI in COVID-19-related ARDS in comparison with non-COVID-19-related ARDS: insights from two prospective global cohort studies / M. Bairbre A., R. Emanuele, S. Andrew J., K. Sankalp, S. Jacky Y., Y. Pauline, B. Daniel, B. Gianluigi Li, P. Tai, B. Giacomo, F. John F., L. John, C. Cccc, T. Al-Dabbous, H. Alfoudri, M. Shamsah, Q. Alhadad, M. Hanan, S. Elapavaluru, A. Berg, C. Horn, A. Reda Mohamed Elsayed Abdelhalim, A. Essam Amer, C. Omar Rageh Elnaggar, A. Ayman Hassan, A. Abdelaziz, M. Abdelhalim, Y. Samir Shaaban Aly Orabi, Z.A. Alaraji, M.R. Muhaisen, L. Almasri, D. Mustafa, S. Hamdan, Y. Al-Saba’a, Z. Dalloul, M. Alkahlout, H. Jaber, O. Aldabbourosama, A.A.R. Mohamed Hussein, Z. Kamel Emad, S. Khaled, N. Mohamed, E. Hassanin, A. Hamdi, A. Ragab, M.G. Azizeldin, Y. Mayasi, S. Schroll, D. Meyer, J. Velazco, L. Ploskanych, W. Fikes, R. Bagewadi, M. Dao, H. White, A. Berrios Laviena, A. Ehlers, M. Shalabi-McGuire, T. Witt, L. Grazioli, L. Lorini, E. Wilson Grandin, J. Nunez, T. Reyes, D. O’Briain, S. Hunter, M. Ramanan, J. Affleck, H. Hurkadli Veerendra, S. Rai, J. Russell-Brown, M. Nourse, M. Joseph, B. Mitchell, M. Tenzer, R. Abe, H. Jin Cho, I. Seok Jeong, N. Rahman, V. Kakar, H. Sun, A. Hanley, N. Brozzi, O. Mehkri, S. Krishnan, A. Duggal, S. Houltham, J. Graf, R. Diaz, R. Orrego, C. Delgado, J. González, M. Soledad Sanchez, M. Piagnerelli, J. Valenzuela Sarrazin, G. Zabert, L. Espinosa, P. Delgado, V. Delgado, D. Fernando Bautista Rincón, A. Maria Marulanda Yanten, M. Bustamante Duque, D. Brodie, K. Abouelmagd, A. Elhazmi, A. Al-Hudaib, J. Javidfar, M. Callahan, A. Dong, C. Crepy D’Orleans, M. Azhari Taufik, E. Yasmin Wardoyo, M. Gunawan, N.S. Trisnaningrum, V. Irawany, M. Rayhan, M. Panigada, A. Pesenti, A. Zanella, G. Grasselli, S. Colombo, C. Martinet, G. Florio, M. Antonelli, S. Carelli, D.L. Grieco, M. Asaki, K. Hoshino, L. Salazar, M. Alejandra Mendoza Monsalve, J. Laffey, B. Mcnicholas, D. Cosgrave, M. Atif, F. Qutishat, C. Laffey, M. Van Der Walt, J. Mccaffrey, A. Bone, Y. Hakeem, J. Winearls, M. Tallott, D. Thomson, I. Joubert, C. Arnold-Day, J. Piercy, R. Van Zyl Smit, M. Miller, L. Seymour, F. Van Heyningen, G. Teyangesikayi, D. Fredericks, A. Ait Hssain, J. Aliudin, A. Alqahtani, K. Mohamed, A. Mohamed, D. Tan, J. Villanueva, A. Zaqout, E. Kurtzman, A. Ademi, A. Dobrita, K. El Aoudi, J. Segura, G. Giwangkancana, S. Ohshimo, J. Osatnik, A. Joosten, A. Torres, M. Yang, A. Motos, C. Luna, F. Arancibia, V. Williams, A. Noel, N. Luque, M. Fantini, R. Noemi Jorge García, E. Chicote Alvarez, A. Greti, A. Ceccato, A. Sanchez, A. Loza Vazquez, F. Roche-Campo, D. Franch-Llasat, D. Tuazon, M. Amato, L. Cassimiro, F. Pola, F. Ribeiro, G. Fonseca, H. Dalton, M. Desai, E. Osborn, H. Deeb, A. Arcadipane, G. Martucci, G. Panarello, S. Vitiello, C. Bianco, G. Occhipinti, M. Rossetti, R. Cuffaro, S. Cho, G. Whitman, M. El Sayed, W. Mokhtar, E. El-Shenawy, H. Shimizu, N. Moriyama, J. Kim, N. Kitamura, J. Gebauer, T. Yokoyama, A. Al-Fares, S. Buabbas, E. Alamad, F. Alawadhi, K. Alawadi, M. Ahmed Khalefa, N. Ahmad Abdulaziz Al Ajeel, M. Fathy Aly, A. Al-Saleh, A. Naanouh, A. Mohammed Elshourbgy, A. Al-Fares, M. Yousef Gad, R. Mohamed Elrazaz, I. Khadadah, A. Mohammed Almumin, H. Altarakma, H. Albannay, M. Kh Alsaleh, M. Saad Abdallah Radwan, I. Ahmed Saadallah, H. Tanaka, S. Hashimoto, M. Yamazaki, T. Oh, M. Epler, C. Forney, L. Kruse, J. Feister, J. Williamson, K. Grobengieser, E. Gnall, S. Golden, M. Caroline, T. Shapiro, C. Karaj, L. Thome, L. Sher, M. Vanderland, M. Welch, S. Mcdermott, M. Brain, S. Mineall, M. Unwin, L. Chen, T. Trezise, L. Mckeon, D. Kimura, L. Brazzi, G. Sales, G. Montrucchio, T. Ogston, D. Nagpal, K. Fischer, R. Lorusso, B. Van Bussell, M. Elena De Piero, S. Mariani, R. Rangappa, R. Mohan Shetty, P. Sujin Rai, A. Ganesan, M. Esperatti, N. Angélica Fuentes, M. Eugenia Gonzalez, D. O’Briain, E.G. Carton, A. Sen, A. Palacios, D. Rainey, G. 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Epidemiology and outcomes of early-onset AKI in COVID-19-related ARDS in comparison with non-COVID-19-related ARDS: insights from two prospective global cohort studies

McNicholas, Bairbre A.;Rezoagli, Emanuele;Simpkin, Andrew J.;Khanna, Sankalp;Suen, Jacky Y.;Yeung, Pauline;Brodie, Daniel;Bassi, Gianluigi Li;Pham, Tai;Bellani, Giacomo;Fraser, John F.;Laffey, John;Consortium Cccc;Tala Al-Dabbous;Huda Alfoudri;Mohammed Shamsah;Qamrah Alhadad;Matly Hanan;Subbarao Elapavaluru;Ashley Berg;Christina Horn;Ahmed Reda Mohamed Elsayed Abdelhalim;Amro Essam Amer;Cinderella Omar Rageh Elnaggar;Ahmed Ayman Hassan;Ali Abdelaziz;Mohamed Abdelhalim;Yehia Samir Shaaban Aly Orabi;Zinah A. Alaraji;Mo’nes R. Muhaisen;Lana Almasri;Dana Mustafa;Shaher Hamdan;Yousef Al-Saba’a;Zaina Dalloul;Mohammed Alkahlout;Hamza Jaber;Osama Aldabbourosama;Aliae A. R. Mohamed Hussein;Zarief Kamel Emad;Sarah Khaled;Nouralsabah Mohamed;Ebtisam Hassanin;Abdelhafeez Hamdi;Abdelrahman Ragab;Mohammed G. Azizeldin;Yunis Mayasi;Stephan Schroll;Dan Meyer;Jorge Velazco;Ludmyla Ploskanych;Wanda Fikes;Rohini Bagewadi;Marvin Dao;Haley White;Alondra Berrios Laviena;Ashley Ehlers;Maysoon Shalabi-McGuire;Trent Witt;Lorenzo Grazioli;Luca Lorini;E. Wilson Grandin;Jose Nunez;Tiago Reyes;Diarmuid O’Briain;Stephanie Hunter;Mahesh Ramanan;Julia Affleck;Hemanth Hurkadli Veerendra;Sumeet Rai;Josie Russell-Brown;Mary Nourse;Mark Joseph;Brook Mitchell;Martha Tenzer;Ryuzo Abe;Hwa Jin Cho;In Seok Jeong;Nadeem Rahman;Vivek Kakar;Helen Sun;Alison Hanley;Nicolas Brozzi;Omar Mehkri;Sudhir Krishnan;Abhijit Duggal;Stuart Houltham;Jerónimo Graf;Roderigo Diaz;Roderigo Orrego;Camila Delgado;Joyce González;Maria Soledad Sanchez;Michael Piagnerelli;Josefa Valenzuela Sarrazin;Gustavo Zabert;Lucio Espinosa;Paulo Delgado;Victoria Delgado;Diego Fernando Bautista Rincón;Angela Maria Marulanda Yanten;Melissa Bustamante Duque;Daniel Brodie;Khaled Abouelmagd;Alyaa Elhazmi;Abdullah Al-Hudaib;Jeff Javidfar;Maria Callahan;Andy Dong;Charles Crepy D’Orleans;M. Azhari Taufik;Elizabeth Yasmin Wardoyo;Margaretha Gunawan;Nurindah S. Trisnaningrum;Vera Irawany;Muhammad Rayhan;Mauro Panigada;Antonio Pesenti;Alberto Zanella;Giacomo Grasselli;S. Colombo;Chiara Martinet;Gaetano Florio;Massimo Antonelli;Simone Carelli;Domenico L. Grieco;Motohiro Asaki;Kota Hoshino;Leonardo Salazar;Mary Alejandra Mendoza Monsalve;John Laffey;Bairbre McNicholas;David Cosgrave;Minha Atif;Fadi Qutishat;Caoimhe Laffey;Michaeala Van Der Walt;Joseph McCaffrey;Allison Bone;Yusuff Hakeem;James Winearls;Mandy Tallott;David Thomson;Ivan Joubert;Christel Arnold-Day;Jenna Piercy;Richard van Zyl Smit;Malcom Miller;Lisa Seymour;Francois van Heyningen;Gilbert Teyangesikayi;David Fredericks;Ali Ait Hssain;Jeffrey Aliudin;Al-Reem Alqahtani;Khoulod Mohamed;Ahmed Mohamed;Darwin Tan;Joy Villanueva;Ahmed Zaqout;Ethan Kurtzman;Arben Ademi;Ana Dobrita;Khadija El Aoudi;Juliet Segura;Gezy Giwangkancana;Shinichiro Ohshimo;Javier Osatnik;Anne Joosten;Antoni Torres;Minlan Yang;Ana Motos;Carlos Luna;Francisco Arancibia;Virginie Williams;Alexandre Noel;Nestor Luque;Marina Fantini;Ruth Noemi Jorge García;Enrique Chicote Alvarez;Anna Greti;Adrian Ceccato;Angel Sanchez;Ana Loza Vazquez;Ferran Roche-Campo;Diego Franch-Llasat;Divina Tuazon;Marcelo Amato;Luciana Cassimiro;Flavio Pola;Francis Ribeiro;Guilherme Fonseca;Heidi Dalton;Mehul Desai;Erik Osborn;Hala Deeb;Antonio Arcadipane;Gennaro Martucci;Giovanna Panarello;Stefano Vitiello;Claudia Bianco;Giovanna Occhipinti;Matteo Rossetti;Raffaele Cuffaro;Sung-Min Cho;Glenn Whitman;Marwan El Sayed;Walaa Mokhtar;Eslam El-Shenawy;Hiroaki Shimizu;Naoki Moriyama;Jae-Burm Kim;Nobuya Kitamura;Johannes Gebauer;Toshiki Yokoyama;Abdulrahman Al-Fares;Sarah Buabbas;Esam Alamad;Fatma Alawadhi;Kalthoum Alawadi;Mohamed Ahmed Khalefa;Nourah Ahmad Abdulaziz Al Ajeel;Mohammad Fathy Aly;Abdullah Al-Saleh;Abdullah Naanouh;Alaa Mohammed Elshourbgy;Abdulrahman Al-Fares;Mohamed Yousef Gad;Rania Mohamed ElRazaz;Ibrahim Khadadah;Ahmed Mohammed Almumin;Hala Altarakma;Hasan Albannay;Mohammed Kh Alsaleh;Mahmoud Saad Abdallah Radwan;Islam Ahmed Saadallah;Hiro Tanaka;Satoru Hashimoto;Masaki Yamazaki;Tak-Hyuck Oh;Mark Epler;Cathleen Forney;Louise Kruse;Jared Feister;Joelle Williamson;Katherine Grobengieser;Eric Gnall;Sasha Golden;Mara Caroline;Timothy Shapiro;Colleen Karaj;Lisa Thome;Lynn Sher;Mark Vanderland;Mary Welch;Sherry McDermott;Matthew Brain;Sarah Mineall;Maria Unwin;Lixian Chen;Tarnya Trezise;Laurie McKeon;Dai Kimura;Luca Brazzi;Gabriele Sales;Giorgia Montrucchio;Tawnya Ogston;Dave Nagpal;Karlee Fischer;Roberto Lorusso;Bas van Bussell;Maria Elena De Piero;Silvia Mariani;Rajavardhan Rangappa;Rajesh Mohan Shetty;P. Sujin Rai;Argin Ganesan;Mariano Esperatti;Nora Angélica Fuentes;Maria Eugenia Gonzalez;Diarmuid O’Briain;Edmund G. Carton;Ayan Sen;Amanda Palacios;Deborah Rainey;Gordan Samoukoviv;Josie Campisi;Lucia Durham;Emily Neumann;Cassandra Seefeldt;Octavio Falcucci;Amanda Emmrich;Jennifer Guy;Carling Johns;Kelly Potzner;Catherine Zimmermann;Angelia Espinal;Nina Buchtele;Michael Schwameis;Andrea Korhnfehl;Roman Brock;Thomas Staudinger;Stephanie-Susanne Stecher;Michaela Barnikel;Sófia Antón;Alexandra Pawlikowski;Akram Zaaqoq;Lan Anh Galloway;Caitlin Merley;Alistair Nichol;Marc Csete;Luisa Quesada;Isabela Saba;Daisuke Kasugai;Hiroaki Hiraiwa;Taku Tanaka;Eva Marwali;Yoel Purnama;Santi Rahayu Dewayanti;Ardiyan;Dafsah Arifa Juzar;Debby Siagian;Yih-Sharng Chen;Mark Ogino;Prashant Nasa;Christina Matthew;Nimisha Abdul Majeed;Indrek Ratsep;Andra-Maris Post;Piret Sillaots;Anneli Krund;Merili-Helen Lehiste;Tanel Lepik;Frank Manetta;Effe Mihelis;Iam Claire Sarmiento;Mangala Narasimhan;Michael Varrone;Mamoru Komats;Julia Garcia-Diaz;Catherine Harmon;S. Veena Satyapriya;Amar Bhatt;Nahush A. Mokadam;Alberto Uribe;Alicia Gonzalez;Haixia Shi;Johnny McKeown;Joshua Pasek;Juan Fiorda;Marco Echeverria;Rita Moreno;Bishoy Zakhary;Marco Cavana;Alberto Cucino;Giuseppe Foti;Marco Giani;Benedetta Fumagalli;Davide Chiumello;Valentina Castagna;Andrea Dell’Amore;Paolo Navalesi;Hoi-Ping Shum;Alain Vuysteke;Asad Usman;Andrew Acker;Benjamin Smood;Blake Mergler;Federico Sertic;Madhu Subramanian;Alexandra Sperry;Nicolas Rizer;Erlina Burhan;Menaldi Rasmin;Ernita Akmal;Faya Sitompul;Navy Lolong;Bhat Naivedh;Simon Erickson;Peter Barrett;David Dean;Julia Daugherty;Antonio Loforte;Irfan Khan;Mohammed Abraar Quraishi;Olivia DeSantis;Dominic So;Darshana Kandamby;Jose M. Mandei;Hans Natanael;Eka YudhaLantang;Anastasia Lantang;Surya Oto Wijaya;Anna Jung;George Ng;Wing Yiu Ng;Pauline Yeung Ng;Shu Fang;Alexis Tabah;Megan Ratcliffe;Maree Duroux;Ahmed Alajeeli;Ali Tarhabat;Shingo Adachi;Shota Nakao;Pablo Blanco;Ana Prieto;Jesús Sánchez;Meghan Nicholson;Warwick Butt;Alyssa Serratore;Carmel Delzoppo;Pierre Janin;Elizabeth Yarad;Richard Totaro;Jennifer Coles;Bambang Pujo;Robert Balk;Andy Vissing;Esha Kapania;James Hays;Samuel Fox;Garrett Yantosh;Pavel Mishin;Saptadi Yuliarto;Kohar Hari Santoso;Susanthy Djajalaksana;Arie Zainul Fatoni;Masahiro Fukuda;Keibun Liu;Paolo Pelosi;Denise Battaglini;Juan Fernando Masa Jiménez;Diego Bastos;Sérgio Gaião;Desy Rusmawatiningtyas;Young-Jae Cho;Su Hwan Lee;Tatsuya Kawasaki;Laveena Munshi;Pranya Sakiyalak;Prompak Nitayavardhana;Mohamed Bashir Elagili;Talat Ahmed Abu Salem;Tamara Seitz;Rakesh Arora;David Kent;Daniel Marino;Swapnil Parwar;Andrew Cheng;Jennene Miller;Shigeki Fujitani;Naoki Shimizu;Jai Madhok;Clark Owyang;Hergen Buscher;Claire Reynolds;Olavi Maasikas;AleksanBeljantsev;Vladislav Mihnovits;Takako Akimoto;Mariko Aizawa;Kanako Horibe;Ryota Onodera;Carol Hodgson;Aidan Burrell;Meredith Young;Timothy George;Kiran Shekar;Niki McGuinness;Lacey Irvine;Brigid Flynn;Tomoyuki Endo;Kazuhiro Sugiyama;Keiki Shimizu;Eddy Fan;Kathleen Exconde;Shingo Ichiba;Muhannud Binnawara;Leslie Lussier;Gösta Lotz;Maximilian Malfertheiner;Lars Maier;Esther Dreier;Neurinda Permata Kusumastuti;Colin McCloskey;Al-Awwab Dabaliz;Tarek B. Elshazly;Josiah Smith;Konstanty S. Szuldrzynski;Piotr Bielański;Yusuff Hakeem;Keith Wille;Srinivas Murthy;Ken Kuljit S. Parhar;Kirsten M. Fiest;Cassidy Codan;Anmol Shahid;Mohamed Fayed;Timothy Evans;Rebekah Garcia;Ashley Gutierrez;Hiroaki Shimizu;Tae Song;Rebecca Rose;Suzanne Bennett;Denise Richardson;Giles Peek;Lovkesh Arora;Kristina Rappapport;Kristina Rudolph;Zita Sibenaller;Lori Stout;Alicia Walter;Daniel Herr;Nazli Vedadi;Robert Bartlett;Antonio Pesenti;Shaun Thompson;Julie Hoffman;Xiaonan Ying;Bailey Williams;Emely Sanchez;Chika Akwani;Ryan Kennedy;Muhammed Elhadi;Matthew Griffee;Mary Mone;Anna Ciullo;Yuri Kida;Ricard Ferrer Roca;JordI Riera;Sofia Contreras;Cynthia Alegre;Christy Kay;Irene Fischer;Elizabeth Renner;Hayato Taniguci;James Lee;Daniel Plotkin;Barbara Wanjiru Citarella;Laura Merson;Emma Hartley;Bastian Lubis;Takanari Ikeyama;Ameen Alhamad;Mohamed Fathi;Mohammed Maher Hadhoud;Hasan Alhouri;Ahmed Mechi;Mohammed Saleh Alyasiri;Muhammed Zainab Alghali Elsaid;Hamza Shahla;Balu Bhaskar;Jae-Seung Jung;Shay McGuinness;Glenn Eastwood;Sandra Rossi Marta;Fabio Guarracino;Stacy Gerle;Emily Coxon;Bruno Claro;Mahmoud Eleisawy;Hasnaa Osama;Daniel Loverde;Namrata Patil;Vieri Parrini;Angela McBride;Kathryn Negaard;Angela Ratsch;Ahmad Abdelaziz;Juan David Uribe;Adriano Peris;Mark Sanders;Dominic Emerson;Muhammad Kamal;Hamza Faida;Pedro Povoa;Roland Francis;Ali Cherif;Sunimol Joseph;Matteo Di Nardo;Micheal Heard;Kimberly Kyle;Ray A. Blackwell;Amel Ouyahia;Michael Piagnerelli;Patrick Biston;Hye Won Jeong;Reanna Smith;Yogi Prawira;Giorgia Montrucchio;Arturo Huerta Garcia;Nahikari Salterain;Bart Meyns;Muhammed Elnasser;Marsha Moreno;Rajat Walia;Amit Mehta;Annette Schweda;Melissa Williams;Emad Amkhatirah;Kyung Hoon Kim;Alexandra Assad;Estefania Giraldo;Wojtek Karolak;Martin Balik;Elizabeth Pocock;Akram Mohamed;Evan Gajkowski;Kanamoto Masafumi;Nicholas Barrett;Yoshihiro Takeyama;Sunghoon Park;Faizan Amin;Fina Meilyana Andriyani;Serhii Sudakevych;Janos Schnur;Angela Ratsch;Magdalena Vera;Rodrigo Cornejo;Patrícia Schwarz;Ana Carolina Mardini;Thais de Paula;Ary Serpa Neto;Andrea Villoldo;Alexandre Siciliano Colafranceschi;Alejandro Ubeda Iglesias;Juan Granjean;Lívia Maria Garcia Melro;Giovana Fioravante Romualdo;Diego Gaia;Helmgton Souza;Filomena Galas;Rafael Máñez Mendiluce;Alejandra Sosa;Ignacio Martinez;Hiroshi Kurosawa;Mohammad Badr Almoshantaf;Juan Salgado;Beate Hugi-Mayr;Eric Charbonneau;Vitor Salvatore Barzilai;Veronica Monteiro;Rodrigo Ribeiro de Souza;Michael Harper;Nidhal Siddig;Hiroyuki Suzuki;Celina Adams;Jorge Brieva;Almu’atasim Khamees;Fadi Graige;Moh Supriatna;George Nyale;Faisal Saleem Eltatar;Jihan Fatani;Husam Baeissa;Ayman A. L. Masri;Ahmed Rabie;Mok Yee Hui;Masahiro Yamane;Hanna Jung;Ayorinde Mojisola Margaret;Newell Nacpil;Katja Ruck;Rhonda Bakken;Claire Jara;Tim Felton;Samar Tharwat;Lorenzo Berra;Bobby Shah;Arpan Chakraborty;Monika Cardona;Gerry Capatos;Bindu Akkanti;Abiodun Orija;Harsh Jain;Asami Ito;Mohamed Muftah;Brahim Housni;Amer Aldhalia;Sennen Low;Koji Iihara;Joselito Chavez;Kollengode Ramanathan;Gustavo Zabert;Krubin Naidoo;Ian Seppelt;Marlice VanDyk;Sarah MacDonald;Shingo Ichiba;Wael Hafez;Randy McGregor;Teka Siebenaler;Hannah Flynn;Kristi Lofton;Toshiyuki Aokage;Bakar Kvirkvelia;Kazuaki Shigemitsu;Andrea Moscatelli;Giuseppe Fiorentino;Matthias Baumgaertel;Serge Eddy Mba;Jana Assy;Amelya Hutahaean;Holly Roush;Kay A. Sichting;Francesco Alessandri;Debra Burns;Taha Husayn Alkhubouli;Ahmad Nasrallah;Ahmed Rabie;Gavin Salt;Carl P. Garabedian;Jonathan Millar;Malcolm Sim;Adrian Mattke;Danny McAuley;Jawad Tadili;Tim Frenzel;Yaron Bar-Lavie;Aaron Blandino Ortiz;Jackie Stone;Alexis Tabah;Antony Attokaran;Michael Farquharson;Brij Patel;Derek Gunning;Kenneth Baillie;Safia Adem;Pia Watson;Kenji Tamai;Gede Ketut Sajinadiyasa;Dyah Kanyawati;Marcello Salgado;Assad Sassine;Bhirowo Yudo;Scott McCaul;Bongjin Lee;Sang Min Lee;Arnon Afek;Yoshiaki Iwashita;Hammad Fadlalmola;Bambang Pujo Semedi;Neurinda Permata Kusumastuti;Noureldin Mohamed Mansour;Jack Metiva;Nicole Van Belle;Ignacio Martin-Loeches;Mohammed Al-Sadawi;Cenk Kirakli;Al-Touny Shimaa;Abusalama Abdurraouf;Lenny Ivatt;Saad Moharam;Chia Yew Woon;Hyun Mi Kang;Timothy Smith;Erskine James;Nawar Al-Rawas;Abdulrahman Almjersah;Yudai Iwasaki;Hamza Ashour;Hussein Embarek;Kenny Chan King-Chung;Vadim Gudzenko;Beate Hugi-Mayr;Fabio Taccone;Fajar Perdhana;Yoan Lamarche;Joao Miguel Ribeiro;Nikola Bradic;Klaartje Van den Bossche;Oude Lansink;Gurmeet Singh;Gerdy Debeuckelaere;Henry T. Stelfox;Cassia Yi;Jennifer Elia;Thomas Tribble;Shyam Shankar;Raj Padmanabhan;Bill Hallinan;Luca Paoletti;Yolanda Leyva;Tatuma Fykuda;Jenelle Badulak;Jillian Koch;Lisa Janowaik;Amy Hackman;Deb Hernandez;Jennifer Osofsky;Katia Donadello;Aizah Lawang;Josh Fine;Benjamin Davidson;Andres Oswaldo Razo Vazquez &;Ibrahim Abdehaleem

2023

Abstract

Background Acute kidney injury (AKI) is a frequent and severe complication of both COVID-19-related acute respiratory distress syndrome (ARDS) and non-COVID-19-related ARDS. The COVID-19 Critical Care Consortium (CCCC) has generated a global data set on the demographics, management and outcomes of critically ill COVID-19 patients. The LUNG-SAFE study was an international prospective cohort study of patients with severe respiratory failure, including ARDS, which pre-dated the pandemic. Methods The incidence, demographic profile, management and outcomes of early AKI in patients undergoing invasive mechanical ventilation for COVID-19-related ARDS were described and compared with AKI in a non-COVID-19-related ARDS cohort. Results Of 18,964 patients in the CCCC data set, 1699 patients with COVID-19-related ARDS required invasive ventilation and had relevant outcome data. Of these, 110 (6.5%) had stage 1, 94 (5.5%) had stage 2, 151 (8.9%) had stage 3 AKI, while 1214 (79.1%) had no AKI within 48 h of initiating invasive mechanical ventilation. Patients developing AKI were older and more likely to have hypertension or chronic cardiac disease. There were geo-economic differences in the incidence of AKI, with lower incidence of stage 3 AKI in European high-income countries and a higher incidence in patients from middle-income countries. Both 28-day and 90-day mortality risk was increased for patients with stage 2 (HR 2.00, p < 0.001) and stage 3 AKI (HR 1.95, p < 0.001). Compared to non-COVID-19 ARDS, the incidence of shock was reduced with lower cardiovascular SOFA score across all patient groups, while hospital mortality was worse in all groups [no AKI (30 vs 50%), Stage 1 (38 vs 58%), Stage 2 (56 vs 74%), and Stage 3 (52 vs 72%), p < 0.001]. The time profile of onset of AKI also differed, with 56% of all AKI occurring in the first 48 h in patients with COVID-19 ARDS compared to 89% in the non-COVID-19 ARDS population. Conclusion AKI is a common and serious complication of COVID-19, with a high mortality rate, which differs by geo-economic location. Important differences exist in the profile of AKI in COVID-19 versus non-COVID-19 ARDS in terms of their haemodynamic profile, time of onset and clinical outcomes.

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	Parole chiave
	
				Acute kidney injury; Cohort study; COVID-19; 28-day mortality; 90-day mortality; Outcome; ARDS
			
	Settori scientifico-disciplinari dell'articolo (validi dal 09/05/2024)
	
				Settore MEDS-23/A - Anestesiologia
			
	Data di pubblicazione
	
				2023
			
	Data ahead of print o data di stampa
	
				5-gen-2023
			
	Rivista in ANCE
	
				CRITICAL CARE
			
	DOI
	
				https://dx.doi.org/10.1186/S13054-023-04487-6
			
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/2434/1190635

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