Vericiguat for patients with heart failure and reduced ejection fraction across the risk spectrum: an individual participant data analysis of the VICTORIA and VICTOR trials

Zannad, F.; O'Connor, C.M.; Butler, J.; Mcmullan, C.J.; Anstrom, K.J.; Barash, I.; Bonaca, M.P.; Borentain, M.; Corda, S.; Gates, D.; Ezekowitz, J.A.; Hernandez, A.F.; Lam, C.S.P.; Lewis, E.F.; Lindenfeld, J.; Mentz, R.J.; Ponikowski, P.; Reddy, Y.N.V.; Rosano, G.M.C.; Saldarriaga, C.; Senni, M.; Teixeira, P.P.; Udelson, J.; Urbinati, A.; Vlajnic, V.; Voors, A.A.; Xing, A.; Patel, M.J.; Armstrong, P.W.; Armstrong, P.W.; O'Connor, C.M.; Pieske, B.; Anstrom, K.J.; Butler, J.; Ezekowitz, J.A.; Hernandez, A.F.; Lam, C.S.P.; Koglin, J.; Ponikowski, P.; Roessig, L.; Voors, A.A.; Reay, K.; Soulard, L.; Temple, T.; Westerhout, C.; Mentz, R.J.; Patel, M.J.; Hamlin, C.; Lovett, R.; Ryan, N.; Blaustein, R.; Golm, G.; Jia, G.; Kent, C.; De Klerk, J.; Salerno, C.; Broeker-Zweering, S.; Nkulikiyinka, R.; Elaine, W.; Mueller, K.; Pieske-Kraigher, E.; Kropf, M.; Kim, R.J.; Parker, M.; Kelle, S.; Schulz-Menger, J.; Defilippi, C.; Bell, R.; Shah, P.; Shaw, P.; Lassman, M.; Kramer, F.; Christenson, R.; Mark, D.; Davidson-Ray, L.; Bahit, M.C.; Kaye, D.M.; Bonderman, D.; Pouleur, A.; Bocchi, E.A.; Lanas, F.; Zhang, J.; Saldarriaga, C.; Melenovský, V.; Refsgaard, J.; Lassus, J.; Cohen-Solal, A.; Edelmann, F.; Tziakas, D.N.; Arango Benecke, J.L.; Siu, D.; Noori, E.; Mcdonald, K.; Lewis, B.S.; Emdin, M.; Senni, M.; Tsutsui, H.; Zainal Abidin, I.; Escobedo, J.; Mosterd, A.; Troughton, R.W.; Atar, D.; Godoy Palomino, A.L.; Reyes, E.B.; Vazquez-Tanus, J.B.; Cho, M.; Lopatin, Y.; Sim, D.; Sliwa-Hähnle, K.; López-Sendón, J.; Lund, L.H.; Chiang, C.; Oto, M.A.; Cowie, M.; Givertz, M.M.; Piña, I.L.; K. Sweitzer, N.; Mcmurray, J.J.V.; Granger, C.B.; Cook, T.D.; Francis, G.S.; Swedberg, K.; Hedlin, H.; Felker, G.M.; Jones, W.S.; Alexander, K.P.; Al-Khatib, S.M.; Dombrowski, K.E.; Harrison, R.W.; Lopes, R.D.; Mathews, R.; Povsic, T.J.; Roe, M.T.; Vemulapalli, S.; Perna, E.R.; Galarza Salazan, M.; Mackinnon, I.; Eden, F.; Cartasegna, L.; Novas, V.; Luquez, H.A.; Cenci, A.; Hominal, M.A.; Bianchini, M.V.; Ahuad Guerrero, R.A.; Alvarez D Amelio, A.; Poy, C.A.; Poy, M.; Majul, C.R.; Currao, C.; Vottero, E.H.; Perrin, M.; Zaidman, C.J.; Espinosa, M.V.; Zapata, G.; Arias, L.; Sassone, S.A.; Tonelli, L.; Chirino Navarta, D.A.; Mangini, M.; Cuadrado, J.; Bordoni, P.; Kaye, D.; Carter, K.; Amerena, J.; Shanahan, T.; Mckenzie, S.; Stibijl, K.; De Pasquale, C.; Wollaston, F.; Colquhoun, D.M.; Ferreira-Jardim, A.; Chan, A.; Dymmott, G.; Mcquillan, B.; Mohammadi, K.; Cross, D.; Jeffrey, J.; Sindone, A.; Gebran, M.; Shah, A.; Tulloch, G.; William, M.; Conway, B.; Wong, J.; North, D.; Von Lewinski, D.; 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Mei, Y.; Linyan, Y.; Huang, Z.; Zhang, X.; Liu, W.; Lei, L.; Zhao, R.; Gong, J.; Zhang, D.; Zhu, J.; Yang, C.; Wang, C.; Zheng, J.; Xinpei, G.; Mei, X.; Liu, M.; Garcia Amaya, P.; Castano Osorio, W.; Dussan, M.; Quiroz Diaz, F.R.; Prada, Y.; Jaramillo Munoz, C.F.; Zapata, A.; Jaramillo, M.; Bello, S.; Botero, R.; Salazar, S.; Lopez Pareja, M.; Mora, C.; Jaramillo Gomez, N.I.; Garcia, J.C.; Torres, F.; Moncada, M.A.; Velez Gil, L.; Torres, J.A.; Lievano, Y.; Melenovsky, V.; Krausova, M.; Malik, J.; Hajsl, M.; Mala, K.; Vojacek, J.F.; Fridrichova, J.; Malek, F.; Rihova, D.; Cech, V.; Masarikova, L.; Machova, V.; Spinar, J.; Macha, J.; Nechvatal, L.; Egstrup, K.; Moltrup, L.; Haastrup, B.; Jespersen, C.; Nyvad, O.; Tanggaard, L.; Fog, L.; Johansen, P.; Wiggers, H.; Serup-Hansen, K.; Due Lomholdt, J.; Niemann, K.; Nielsen, O.W.; Stokholm, E.; Taskiran, M.; Pedersen, L.R.; Nyman, K.; Sankari, T.; Ukkonen, H.; Vasankari, T.; Karesvuori, S.; Vazquez Ibarra, M.; Gallouj, K.; Lombart, A.; Damy, T.; Karhoubi, M.; Galinier, M.; Rosoli, N.; Taldir, G.; Vomscheid, M.; Tartiere, J.; Genin, C.; Salvat, M.; Pollet, D.; Citron, B.; Lamallem, O.; Girerd, N.; Poinsignon, L.; Jourda, F.; Mougenot, E.; Boughanmi, H.; Fodil, H.; Benhamou, L.; Harzi, G.; Störk, S.; Knoppe, A.; Appel, K.; Becker, P.; Bauersachs, J.; Geyer, M.; Schmidt, E.; Schmidt, K.; Strempel, S.; Beug, D.; Bruder, M.; Jeserich, M.; Rupprecht, M.; Haake, H.; Krug-Hoeren, B.; Hagenow, A.; Kuntzsch, A.; Vojvodic-Mayer, M.; Lux, R.; Horacek, T.; Pluemer-Schmidt, M.; Knapp, M.; Suepple-Poch, E.; Mitrovic, V.; Peil, A.; Rosenkranz, S.; Roelle-Hoehne, S.; Bekeredjian, R.; Probst, I.; Tuleta, I.; Lauterborn, M.; Winkelmann, B.; Tenbusch, L.; Zeh, W.; Eble, S.; Kessler, M.; Dichristin, U.; Maier, L.; Kellner, E.; Tziakas, D.; Chalikias, G.; Triposkiadis, F.; Papamichalis, M.; Parissis, J.; Bistola, V.; Karvounis, H.; Giannakoulas, G.; Tousoulis, D.; Chrysohoou, C.; Naka, K.; Kotsia, A.; Montenegro Valdovinos, P.C.; Aguilar, M.; Gonzalez Orellana, R.A.; 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Morsella, V.; Sarzi Braga, S.; Vaninetti, R.; Agostoni, P.; Salvioni, E.; Taddei, S.; Bruno, R.M.; Parati, G.; Munforti, C.; Lauciello, R.; Coiro, S.; Mortara, A.; Mazzetti, S.; Sinagra, G.; Ramani, F.; Gualco, A.; Cattaneo, S.; Argiolas, G.; Masala, W.; Cosmi, F.; Mariottoni, B.; Nakamura, A.; Futono, K.; Komaru, T.; Endo, T.; Fukuzawa, S.; Nakamura, Y.; Okumura, Y.; Sato, H.; Tabata, H.; Saino, M.; Ikeda, T.; Kaminishi, R.; Ebato, M.; Fukatsu, A.; Aoyama, T.; Kitani, C.; Sakamoto, H.; Amano, K.; Saeki, T.; Shimano, K.; Kada, K.; Tsuzuki, Y.; Hashimoto, T.; Okamoto, M.; Fujii, K.; Tsujimoto, M.; Ichinohe, T.; Okabe, S.; Hirooka, K.; Senshu, Y.; Ohta, T.; Hayashi, T.; Kawai, Y.; Horio, J.; Takaishi, A.; Nakamura, M.; Takatsu, H.; Shiota, T.; Maemura, K.; Nishida, M.; Shibata, Y.; Nagashima, K.; Shibasaki, T.; Takahashi, N.; Iseki, H.; Otsuki, K.; Matsuoka, S.; Motoda, K.; Higuchi, Y.; Hayasaki, H.; Manita, M.; Ito, R.; Suzuki, M.; Fumikura, K.; Iwata, H.; Kinjo, K.; Takimoto, E.; Omori, Y.; Yumoto, K.; Yoshizawa, J.; Izumi, C.; Hirase, K.; Higashiue, S.; Ishibaba, A.; Higashino, Y.; Matsumura, T.; Iida, H.; Kowa, K.; Koga, T.; Hatakeda, T.; Atsuchi, N.; Migita, K.; Momiyama, Y.; Fukuda, Y.; Fukue, M.; Uchida, K.; Saito, K.; Iida, S.; Fukamizu, S.; Harada, J.; Takei, Y.; Takano, S.; Hata, Y.; Sato, A.; Shimura, Y.; Hirata, S.; Namiki, A.; Ishida, N.; Michishita, I.; Ishimoto, T.; Usuda, K.; Oomura, A.; Kinugawa, K.; Sasaki, R.; Matsubara, T.; Kidani, H.; Awaji, Y.; Kaneno, Y.; Yamashita, K.; Suzuki, M.; Fujita, H.; Mashida, A.; Yamada, T.; Hirai, S.; Ichikawa, M.; Muromaki, T.; Ohtani, T.; Yamaguchi, S.; Furukawa, Y.; Takata, M.; Baden, M.; Kawasaki, F.; Tashiro, H.; Kita, Y.; Taki, M.; Suzuki, K.; Nakama, K.; Oota, C.; Hibi, K.; Shiono, M.; Matoba, S.; Kimura, N.; Takahashi, A.; Fujino, M.; Ide, T.; Tanaka, C.; Ueda, O.; Shimojima, R.; Kuramochi, T.; Ando, M.; Onaka, H.; Maeda, A.; Higami, T.; Nishibe, I.; Abe, M.; Matsugi, M.; Ako, J.; Yamamura, K.; Ueda, T.; Itokazu, Y.; Sumii, K.; Ichii, K.; Shimizu, M.; Irikura, M.; Shimizu, S.; Ayabe, M.; Matsubara, T.; Kaneko, S.; Koizumi, T.; Watanabe, K.; Sakagami, S.; Kumaki, M.; Suzuki, A.; Kawano, T.; Katayama, Y.; Nakamura, H.; Taguchi, I.; Araki, Y.; Higa, N.; Oshiro, Y.; Yahikozawa, K.; Anzai, S.; Nunohiro, T.; Nishi, D.; Osaki, S.; Tanaka, Y.; Kaneko, M.; Noguchi, K.; Watanabe, N.; Oishi, T.; Fuse, K.; Baba, Y.; Kim, G.; Jeong, J.; Choi, Y.; Lee, H.; Hur, E.; Kang, S.; Lee, W.; Kim, K.H.; Song, J.; Yoo, B.; Shin, S.; Shin, M.S.; Hei Won, O.; Kim, E.J.; Park, J.; Choi, D.; Yoon, E.J.; Yang, D.H.; Choi, J.; Choi, J.; Jeong, H.; Choi, J.; Hyun, S.J.; Sang-Ho, J.; Sujin, L.; Jin, D.K.; Jeon, J.; Shin, J.; Ji Sung, N.; Kim, D.; Eunryul, O.; Ong, T.K.; Sulehan, J.; Che Hassan, H.H.; Amni, Z.; Zainal Abidin, S.K.; Ravinttiran, K.L.; De Los Rios Ibarra, M.O.; Martinez Sanchez, C.R.; Ronquillo Ramirez, D.; Salazar Gaytan, A.; Gonzalez Sandoval, C.; Alcocer Gamba, M.A.; Munoz Rosales, W.; Esturau Santalo, R.M.; Sanchez Mendoza, Y.; Mendez Machado, G.F.; Hirata Avila, H.; Reyes Araiza, R.; Ruiz Morales, J.; Escobedo De La Pena, J.; Villegas Lara, B.; Lopez Rosas, E.; Meza Hernandez, M.; Chavez Michel, J.; Ruiz Rubio, E.; Varela, A.; Hobé-Rap, C.; Lok, D.; Dommerholt, R.; Swart, H.; Van Scheltinga, C.T.; Van De Wal, R.; Van Lieshout, I.; Van Der Meer, P.; Branderhorst, A.; Werner, H.A.; van Ruijven-Mastenbroek, I.; Meijs, M.F.L.; Oldenhof, L.; Den Hartog, F.; Singerling, M.; Troughton, R.W.; Rose, S.; Hamilton, F.; Jacques, S.; Ferrier, K.; Kovacs, J.; Lund, M.; Pearce, L.; Doughty, R.; Terbals, M.; Amir, N.; Hulbert, C.; Pemberton, J.; Scott, D.; Nilsen, D.; Nilsen, J.; Gullestad, L.; Bjorklund, E.; Claussen, H.; Keilegavlen, H.; Faalun, N.; Ruddox, V.; Pedersen, A.; German Rodriguez Escudero, A.E.; Romero, S.; Orihuela, B.; Del Portal, M.; Rodriguez, V.E.; Cabanillas Gallo, N.; Medina, F.A.; Rodriguez, J.; Lu Galarreta, L.; Espejo, J.; Matta, M.; Salvador, D.R.K.; Cudiamat, W.L.; Reyes, E.; De Guzman, S.; Rody, S.; Silva, C.; Brillantes, A.; Alon-Alon, A.; Iii, G.J.; Cortez, F.J.; Tirador, L.S.; Gamboa, C.D.A.; Habaluyas, R.S.; Incognito, M.J.; Szachniewicz, J.; Nawrocka-Millward, S.; Goch, A.; Lugowski, T.; Nessler, J.; Czubek, U.; Straburzynska Migaj, E.; Przepiora, A.; Pijanowski, Z.; Pijanowska, M.; Kasprzak, J.; Mirek-Bryniarska, E.; Zareba, W.; Musial, W.; Tycinska, A.; Miekus, P.; Przydatek, J.; Krysiak, W.; Skorek, E.; Leszek, P.; Polaska, P.; Skonieczny, G.K.; Roliard, M.; Wujkowski, M.; Strupiechowski, M.; Diago, M.; Baez, J.; Casanova-Jimenez, L.; Zayas-Torres, C.R.; Duran, A.; Colon-Hernandez, P.J.; Carrasquillo, M.; Rios Bonilla, M.L.; Marcano, M.; Garcia-Gordo, P.; Navedo-Santos, J.; Boldueva, S.; Shvets, N.; Orlova, N.; Klepikova, M.; Kastanayan, A.; Babaeva, L.; Meray, I.; Teterina, M.; Shvarts, Y.; Konshina, L.; Yakushin, S.; Filippov, E.; Sayganov, S.; Nikolaev, D.; Vishnevskiy, A.; Zykov, V.; Solovev, O.; Nazarov, D.; Bolshakova, O.; Polunicheva, E.; Treshkur, T.; Berngardt, E.; Nosov, V.; Koroleva, L.; Kamalov, G.; Urazaeva, L.; Ilyukhin, O.; Morozov, E.; David Sim, K.L.; Lee, Y.Y.; Lee, S.G.S.; Tang, X.; Soon, D.K.N.; Lim, B.K.; Wong, R.C.; Wong, C.Y.; Loh, S.Y.; Cheng, G.; Tan, G.; Abelson, M.J.; King, A.; Bayat, J.; Badat, K.; Ranjith, N.; Ramdas, S.; Nunkoo, T.; Prozesky, H.W.; Naude, C.; Fulat, M.A.; Pretorius, M.; Ntsekhe, M.; Mtana, N.; Klug, E.Q.; Naidoo, V.; Pillay-Ramaya, L.; Phillips, S.; Makotoko, E.M.; Page, A.; Malahleha, M.; Pitsoane, M.; Mediavilla Garcia, G.; Gonzalez Juanatey, J.R.; Seijas Amigo, J.; Martínez-Sellés, M.; Sobrino González, O.; González-Ferrer, E.; González, P.; Manito Lorite, N.; Guerrero, S.; Farré López, N.; Soler Ayat, C.; Gomez Doblas, J.J.; Robles, M.; Núñez, J.; Mollar Fernández, A.; Gómez Bueno, M.; González Segovia, A.; Lund, L.; Hultman-Cadring, A.; Pol, T.; Langoe, A.; Hansen, O.; Nake, E.; Danyi, T.; Kruse, A.; Magnusson, C.; Palo, N.; Michael, F.; Fahlen, K.; Bollano, E.; Westlund, A.; Hullin, R.; Salzmann, S.; Moccetti, T.; Serra, A.; Mueller, C.; Flores, D.; Lin, I.; Hwang, J.; Chen, Y.; Chang, W.; Shu-Fen, S.; Chao, T.; Tseng, W.; Yen-Wen, W.; Chen, Y.; Liu, M.; Chou, V.; Cavusoglu, Y.; Yilmaz, M.B.; Sansoy, V.; Sahin, T.; Sezer, M.; Celik, A.; Oto, M.A.; Tengiz, I.; Reshotko, O.; Donets, O.; Rybachok, Y.; Sychov, O.; Romanova, O.; Kulbachuk, O.; Klitsunova, Y.; Velichko, N.; Tomakh, N.; Squire, I.; Fisher, J.; Bethell, H.; Howard, E.; Barr, C.S.; Dean, J.; Clark, A.; Bulemfu, J.; Cooke, J.; Whileman, A.; Davies, C.; Pheby, J.; Mcdonagh, T.; Breeze, J.; Wong, K.; Fleming, C.; Amin, J.; Cervoni, T.; Aslam, S.; Burns, D.; Bank, A.J.; Gernes, N.; Bedwell, N.W.; Craig, M.; Iteld, B.J.; Ocman, B.; Bhalla, R.; Hicks, T.; Chu, A.A.S.P.; Nguyen, S.; Feldman, J.; Peek, M.; George, F.; Baker, C.; Gray, W.L.; Adair, S.; Jetty, P.; Key, A.; Kazemi, N.; Hollis, S.; Larned, J.; Ortiz, M.; Smith, J.L.; Abell, T.; Cadaret, L.; Larew, C.; Long, R.; Hickey, T.; Mahal, S.S.; Yandamuri, S.; Whellan, D.J.; Schwegler, D.; Mccullough, P.; Baker, R.; Mcginty, J.; Fry, N.; Pelzel, J.M.; Douvier, A.; Vilaro, J.; Long, S.; Perlman, R.; Hoopes, D.; Podugu, R.; Smith, K.; Rahko, P.; Olsen, K.J.; Ravichandran, A.; Reilly, B.; Sangrigoli, R.; Schwarz, L.; Greene, T.O.; Jackson, C.; Davis, T.; Spiller, D.; Ferrin, S.; Viswanath, D.B.; Manga, S.; Zi Jian, X.; Holmes-Rees, D.; Bittrick, J.M.; Calhoun, E.; Ewald, G.A.; Bult, K.; Farr, M.; Kim, A.; Forgosh, L.; Riestenberg-Smith, J.; Jaffrani, N.; Childers, R.; Brinkley, D.M.; Carroll, A.; Mclean, D.S.; Pruitt, H.; Lewis, G.; Cocca-Spofford, D.; Snyder, H.A.; Pantuck, L.; Teufel, E.J.; Glasgow, B.; Donovan, D.J.; Alvarado-Garcia, M.M.; Dauber, I.; Derbyshire, S.; Zavaro, S.; Miller, A.; Sharkey, K.; Ferguson, A.; Adams, K.; Glotzer, J.; Perez, J.A.; Addington, J.; Bhatti, Z.; Burton, C.; Melucci, M.B.; Meier, S.; Huber, M.; Anazawa, F.; Upshaw, J.; Carr, K.; Holmberg, M.J.; Rasmussen, L.S.; Lucarella, V.J.; Maloney, K.; Sabatino, K.C.; Everett, J.; Kelley, E.; Murthy, S.; Camillo, A.; 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Rymer, J.; Sasannejad, C.

doi:10.1016/s0140-6736(25)01682-4

Background: Following completion of the VICTORIA trial, vericiguat was approved for the treatment of worsening heart failure with reduced ejection fraction (HFrEF) and received a class IIb recommendation in European and North American guidelines. The subsequent VICTOR trial evaluated the use of vericiguat in patients with HFrEF and no recent worsening. We aimed to assess the effect of vericiguat on clinical endpoints through pooled analyses of patient-level data from the VICTORIA and VICTOR trials. Methods: This prespecified, pooled individual participant-level analysis was conducted on data from two trials: VICTORIA, which was active from Sept 25, 2016, to Sept 2, 2019 in 42 countries, and VICTOR, which was active from Nov 2, 2021, to Feb 5, 2025 in 36 countries. The VICTORIA trial enrolled adult (aged ≥18 years) participants with HFrEF with recent worsening (defined as either hospitalisation for heart failure within the previous 6 months or outpatient use of intravenous diuretics within the previous 3 months) and increased NT-proBNP concentrations; the VICTOR trial had similar eligibility criteria but participants had no recent worsening of heart failure. Participants in both trials received contemporary background guideline-directed heart failure therapy as appropriate. The primary endpoint was a composite endpoint of cardiovascular death or hospitalisation for heart failure (also assessed individually). This study is registered with PROSPERO, CRD420251065636. Findings: Data from 11 155 patients (5050 in the VICTORIA trial and 6105 in the VICTOR trial) were included in the pooled analysis. The primary endpoint of cardiovascular death or hospitalisation for heart failure occurred in 1446 (25·9%) of 5579 patients in the vericiguat group and 1556 (27·9%) of 5576 patients in the placebo group (hazard ratio [HR] 0·91 [95% CI 0·85-0·98]; p=0·0088), with similar reductions in its individual components of cardiovascular death (0·89 [0·80-0·98]; p=0·020) and hospitalisation for heart failure (0·92 [0·84-1·00]; p=0·043) as first events. Interpretation: Vericiguat reduced the risk of hospitalisation for heart failure and cardiovascular death in patients with HFrEF across a broad range of clinical severity, including those receiving contemporary guideline-directed medical therapy. Vericiguat might be suitable as an additional treatment option for selected patients with HFrEF. Funding: Merck Sharp & Dohme (a subsidiary of Merck) and Bayer.

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Vericiguat for patients with heart failure and reduced ejection fraction across the risk spectrum: an individual participant data analysis of the VICTORIA and VICTOR trials

Zannad, Faiez;O'Connor, Christopher M;Butler, Javed;McMullan, Ciaran J;Anstrom, Kevin J;Barash, Irina;Bonaca, Marc P;Borentain, Maria;Corda, Stefano;Gates, Davis;Ezekowitz, Justin A;Hernandez, Adrian F;Lam, Carolyn S P;Lewis, Eldrin F;Lindenfeld, JoAnn;Mentz, Robert J;Ponikowski, Piotr;Reddy, Yogesh N V;Rosano, Giuseppe M C;Saldarriaga, Clara;Senni, Michele;Teixeira, Pedro P;Udelson, James;Urbinati, Alessia;Vlajnic, Vanja;Voors, Adriaan A;Xing, Aiwen;Patel, Mahesh J;Armstrong, Paul W;Armstrong, Paul W.;O'Connor, Christopher M.;Pieske, Burkert;Anstrom, Kevin J.;Butler, Javed;Ezekowitz, Justin A.;Hernandez, Adrian F.;Lam, Carolyn S. P.;Koglin, Joerg;Ponikowski, Piotr;Roessig, Lothar;Voors, Adriaan A.;Reay, Kris;Soulard, Lisa;Temple, Tracy;Westerhout, Cynthia;Mentz, Robert J.;Patel, Mahesh J.;Hamlin, Constance;Lovett, Rhonda;Ryan, Nicholas;Blaustein, Robert;Golm, Gregory;Jia, Gang;Kent, Christi;De Klerk, Jaco;Salerno, Christina;Broeker-Zweering, Sabine;Nkulikiyinka, Richard;Wu, Elaine;Mueller, Katharina;Pieske-Kraigher, Elisabeth;Kropf, Martin;Kim, Raymond J.;Parker, Michele;Kelle, Sebastian;Schulz-Menger, Jeanette;deFilippi, Christopher;Bell, Rachel;Shah, Palak;Shaw, Peter;Lassman, Michael;Kramer, Frank;Christenson, Robert;Mark, Daniel;Davidson-Ray, Linda;Bahit, M. Cecilia;Kaye, David M.;Bonderman, Diana;Pouleur, Anne-Catherine;Bocchi, Edimar A.;Lanas, Fernando;Zhang, Jian;Saldarriaga, Clara;Melenovský, Vojtěch;Refsgaard, Jens;Lassus, Johan;Cohen-Solal, Alain;Edelmann, Frank;Tziakas, Dimitrios N.;Arango Benecke, Juan Luis;Siu, David;Noori, Ebrahim;McDonald, Kenneth;Lewis, Basil S.;Emdin, Michele;Senni, Michele;Tsutsui, Hiroyuki;Zainal Abidin, Imran;Escobedo, Jorge;Mosterd, Arend;Troughton, Richard W.;Atar, Dan;Godoy Palomino, Armando Lionel;Reyes, Eugenio B.;Vazquez-Tanus, Jose B.;Cho, Myeong-Chan;Lopatin, Yury;Sim, David;Sliwa-Hähnle, Karen;López-Sendón, José;Lund, Lars H.;Chiang, Chern-En;Oto, M. Ali;Cowie, Martin;Givertz, Michael M.;Piña, Ileana L.;K. Sweitzer, Nancy;McMurray, John J. V.;Granger, Christopher B.;Cook, Thomas D.;Francis, Gary S.;Swedberg, Karl;Hedlin, Haley;Felker, G. Michael;Jones, W. Schuyler;Alexander, Karen P.;Al-Khatib, Sana M.;Dombrowski, Keith E.;Harrison, Robert W.;Lopes, Renato D.;Mathews, Robin;Povsic, Thomas J.;Roe, Matthew T.;Vemulapalli, Sreekanth;Perna, Eduardo Roque;Galarza Salazan, Maria;MacKinnon, Ignacio;Eden, Florencia;Cartasegna, Luis;Novas, Viviana;Luquez, Hugo A.;Cenci, Ana;Hominal, Miguel Angel;Bianchini, Maria Veronica;Ahuad Guerrero, Rodolfo Andres;Alvarez D Amelio, Andrea;Poy, Carlos Alberto;Poy, Maria;Majul, Claudio R.;Currao, Cecilia;Vottero, Ezequiel Hector;Perrin, Mariana;Zaidman, Cesar Javier;Espinosa, Maria Vanesa;Zapata, Gerardo;Arias, Luciana;Sassone, Sonia Angelica;Tonelli, Lucas;Chirino Navarta, Daniel Agustin;Mangini, Maria;Cuadrado, Jesus;Bordoni, Paula;Kaye, David;Carter, Kaye;Amerena, John;Shanahan, Toni;McKenzie, Scott;Stibijl, Kathryn;De Pasquale, Carmine;Wollaston, Fiona;Colquhoun, David Martin;Ferreira-Jardim, Antonio;Chan, Alicia;Dymmott, Greer;McQuillan, Brendan;Mohammadi, Katayun;Cross, David;Jeffrey, Judy;Sindone, Andrew;Gebran, Magdalena;Shah, Amit;Tulloch, Gill;William, Maged;Conway, Bets;Wong, James;North, Donna;von Lewinski, Dirk;Brandner, Karin;Hoppe, Uta;Kopp, Kristen;Mascherbauer, Regina Steringer;Steinkellner, Claudia;Binder, Christina;Adlbrecht, Christopher;Leitgeb, Maria;Sinnaeve, Florence;Dupont, Matthias;Claes, Carola;De Ceuninck, Michel;Vancayseele, Els;Timmermans, Philippe;Van Genechten, Gregory;Troisfontaines, Pierre;Massoz, Mireille;Huynh, Thao Thanh;Boudreault, Caroline;Sabbah, Eric;Chausse, Isabelle;Bourgeois, Ronald Leonard;Boyd, Karen;Heffernan, Michael;Birch, Marie;Parent, Marie-Claude;Brown, Helene;Pandey, A. Shekhar;Ballivian, Tatiana;Giannetti, Nadia;Sahebjamei, Reza;Vizel, Saul;Fox, Beverley;Rupka, Dennis Wayne;Thiessen, Sandi;Constance, Christian;Gauthier, Marie-France;Kushnerik, Quentin;Schaffer, Allan;Janz, Wendy;Chan, Michael;Knight, Jennifer;Lepage, Serge;Soucy, Daniel;Parker, John D.;Hsu, Elaine;Mielniczuk, Lisa;Moga, Ermina;Coutu, Benoit;Fleury, Julie;MacDonald, Paul;Hines, Kathleen;Delgado, Diego;Nugaeva, Natalia;Sia, Ying;Roy, Isabelle;Laflamme, David;Simard, Christel;Gosselin, Gilbert;Drouin, Katia;Clarke, Brian;Ronak, Kimberley;Saulnier, Denis;Cote, Melissa;Sussex, Bruce Alexander;Druken, Bernadette;Rajda, Miroslaw;Falkenham, Jayne;Mukherjee, Ashok;Bozek, Beverly;Ling Moe, Gordon Willy Pak;Fernando, Carlos;Bergeron, Sebastien;Tremblay, Hugo;Shibata, Marcelo Coelho;Woloschuk, Bonnie;Manyari, Dante;Cleveland, Tracy;Nigro, Frank;Forsyth, Crystal;Roy, Annie;Bolduc, Helene;Dion, Danielle;Gilbert, Nancy;Cha, James Y;Otis, Judy;Barabas, Melinda;Chartrand, Marie-Josee;Assef, Victor;Eikhof, Andrea;Novajas Balboa, Manuel;Aravena Vasquez, Carla Belen;Prieto Dominguez, Juan Carlos;Noriega, Viviana;Yovaniniz, Patricio;Grandon, Marcela;Hidalgo, Jessica;Zhang, Yuhui;Dong, Jing;Dai, Haiying;Xiao, Ying;Jiang, Tingbo;Shi, Lin;Chen, Jiyan;He, Peiyu;Peng, Daoquan;Qing, Fangmei;Xu, Biao;Wang, Ruihong;Gu, Xiang;Wang, Min;Yao, Zhuhua;Chen, Ying;Miao, Peizhi;Chen, Zhenfei;Li, Hui;Huang, Dongyan;Yang, Qing;Yu, Xuefang;Shen, Aidong;Zhang, Xin;Liu, Xiaohui;Lv, Qiang;Dong, Yugang;Liu, Dan;Wang, Jingfeng;Ouyang, Huijun;Tang, Chengchun;Chen, Yong;Gong, Hui;Teng, Dandan;Yan, Jing;Xu, Linying;Jiang, Weihong;Zhou, Xiaowei;Fu, Guosheng;Zheng, Ying;Zhang, Shuyang;Xu, Lihong;Yang, Zhenyu;Wu, Chenying;Han, Xiumin;Wang, Yuxia;Yu, Jing;Wang, Qiongying;Wang, Lihong;Zheng, Lili;Jin, Wei;Zhang, Nan;Zhang, Chuanhuan;Sun, Xiaojian;Yao, Yali;Lei, Peng;Zheng, Zhaofen;Wang, Junkui;Ma, Fengling;Long, Mingzhi;Wang, Sulan;Zhang, Hong;Guo, Mingmei;Chen, Manhua;Wang, Yayun;Li, Zhanquan;Duan, Ruili;Yuan, Zuyi;Li, Tiaotiao;Mei, Yibin;Ye, Linyan;Huang, Zhouqing;Zhang, Xingyuan;Liu, Wenling;Li, Lei;Zhao, Ruiping;Gong, Jie;Zhang, Dongqing;Zhu, Jiahui;Yang, Chengjian;Wang, Chunxia;Ji, Zheng;Xinpei, Gao;Mei, Xia;Liu, Mingyun;Garcia Amaya, Paula;Castano Osorio, Wilder;Dussan, Maria;Quiroz Diaz, Franklin Roberto;Prada, Yuleth;Jaramillo Munoz, Carlos Francisco;Zapata, Ana;Jaramillo, Monica;Bello, Solmara;Botero, Rodrigo;Salazar, Sandra;Lopez Pareja, Monica;Mora, Claudia;Jaramillo Gomez, Nicolas Ignacio;Garcia, Juan Camilo;Torres, Fabian;Moncada, Miguel Alfredo;Velez Gil, Laura;Torres, Jaime Andres;Lievano, Yolanda;Melenovsky, Vojtech;Krausova, Miroslava;Malik, Jan;Hajsl, Martin;Mala, Katerina;Vojacek, Jan F;Fridrichova, Jana;Malek, Filip;Rihova, Dana;Cech, Vladimir;Masarikova, Lenka;Machova, Vilma;Spinar, Jindrich;Macha, Jan;Nechvatal, Libor;Egstrup, Kenneth;Moltrup, Lene;Haastrup, Benedikte;Jespersen, Camilla;Nyvad, Ole;Tanggaard, Lene;Fog, Lars;Johansen, Pauline;Wiggers, Henrik;Serup-Hansen, Kristine;Due Lomholdt, Jens;Niemann, Kari;Nielsen, Olav Wendelboe;Stokholm, Elisa;Taskiran, Mustafa;Pedersen, Lotte Ring;Nyman, Kai;Sankari, Tiina;Ukkonen, Heikki;Vasankari, Tuija;Karesvuori, Sari;Vazquez Ibarra, Miguel;Gallouj, Karim;Lombart, Angelique;Damy, Thibaud;Karhoubi, Mounira;Galinier, Michel;Rosoli, Nathalie;Taldir, Guillaume;Vomscheid, Maelle;Tartiere, Jean-Michel;Genin, Charline;Salvat, Muriel;Pollet, Delphine;Citron, Bernard;Lamallem, Ouarda;Girerd, Nicolas;Poinsignon, Lydie;Jourda, Francois;Mougenot, Emmanuelle;Boughanmi, Hatem;Fodil, Hanane;Benhamou, Lionel;Harzi, Ghania;Störk, Stefan;Knoppe, Anja;Appel, Karl-Friedrich;Becker, Petra;Bauersachs, Johann;Geyer, Manuela;Schmidt, Ekkehard;Schmidt, Kristina;Strempel, Sophia;Beug, Daniel;Bruder, Michael;Jeserich, Michael;Rupprecht, Mariana;Haake, Hendrik;Krug-Hoeren, Bianca;Hagenow, Andreas;Kuntzsch, Anja;Vojvodic-Mayer, Mirjana;Lux, Ronny;Horacek, Thomas;Pluemer-Schmidt, Manuela;Knapp, Markus;Suepple-Poch, Edith;Mitrovic, Veselin;Peil, Annerose;Rosenkranz, Stephan;Roelle-Hoehne, Susanne;Bekeredjian, Raffi;Probst, Ina;Tuleta, Izabela;Lauterborn, Marjo;Winkelmann, Bernhard;Tenbusch, Linda;Zeh, Wolfgang;Eble, Sandra;Kessler, Mirjam;Dichristin, Uta;Maier, Lars;Kellner, Esther;Tziakas, Dimitrios;Chalikias, Georgios;Triposkiadis, Filippos;Papamichalis, Michalis;Parissis, John;Bistola, Vasiliki;Karvounis, Haralampos;Giannakoulas, Georgios;Tousoulis, Dimitrios;Chrysohoou, Christina;Naka, Katerina;Kotsia, Anna;Montenegro Valdovinos, Pablo Carlos;Aguilar, Mayra;Gonzalez Orellana, Ronaldo A.;Meléndez, Ester;Garcia de Krumbach, Lissette;Rodríguez, Edgar Rolando;Barrera, Karla;Aguilar Vásquez, Mynor Adolfo;Siu, Chung Wah David;Ho, Venus San Lui;Lee, Pui-Wai Alex;Wang, Xue Ting;Fan, Katherine;Tam, Eva;Mihaly, Gyongyver Ibolya;Kalina, Akos;Szabo, Anita;Kancz, Sandor;Hentzel, Istvanne;Lakatos, Ferenc;Toth, Krisztina;Merkely, Bela;Dzsida, Laura;Palinkas, Attila;Toth, Szilvia Rostasne;Svab, Marianna;Bugarin-Horvath, Balazs;Kirschner, Robert J.;Toth Karolyne, Rozsa;Maher, Joanne;Murphy, Ross;Hall, Mary;Mahon, Niall;Gilroy, Elaine;McAdam, Brendan;Farrell, David;O Neill, James;Blaine, Ciara;Atar, Shaul;Nadaf, Rita;Hayek, Tony;Hassan, Mira;Zarachovsky, Lena;Shochat, Michael;Aloni, Ilana;Assali, Abid;Tsirulnikov, Elena;Kinany, Wadi;Etkin, Janna;Ben Gal, Tuvia;Even Nir, Hadas;Arbel, Yaron;Shani, Adi Katalan;Mazen, Elias;Ron Avraham, Gilat;Goland, Sorel;Suzdalnizki, Anastasia;Halabi, Majdi;Portnov, Ilana;Hasin, Tal;Rojansky, Astrid;Jabara, Rafat;Levin, Galina;Katz, Amos;Tubul, Orna;Moravsky, Gil;Lapidus, Ira;Ambrosio, Marilisa;Passino, Claudio;Gabutti, Alessandra;Scelsi, Laura;Vullo, Eleonora;Midi, Paolo;Felici, Anna;Fucili, Alessandro;Sarcone, Maria;Nodari, Savina;Lupi, Laura;Spagnuolo, Vitaliano;Volterrani, Maurizio;Morsella, Valentina;Sarzi Braga, Simona;Vaninetti, Raffaella;P. Agostoni;Salvioni, Elisabetta;Taddei, Stefano;Bruno, Rosa Maria;Parati, Gianfranco;Munforti, Carlotta;Lauciello, Rosanna;Coiro, Stefano;Mortara, Andrea;Mazzetti, Simone;Sinagra, Gianfranco;Ramani, Federica;Gualco, Alessandra;Cattaneo, Simona;Argiolas, Giuseppe;Masala, Wanda;Cosmi, Franco;Mariottoni, Beatrice;Nakamura, Akihiro;Futono, Kazumi;Komaru, Tatsuya;Endo, Tomoko;Fukuzawa, Shigeru;Nakamura, Yumi;Okumura, Yasuo;Sato, Haruka;Tabata, Hirotsugu;Saino, Mizuki;Ikeda, Takanori;Kaminishi, Reiko;Ebato, Mio;Fukatsu, Akiko;Aoyama, Takahiko;Kitani, Chihiro;Sakamoto, Hiroki;Amano, Kaori;Saeki, Tomoaki;Shimano, Kayo;Kada, Kenji;Tsuzuki, Yoko;Hashimoto, Tetsuo;Okamoto, Madoka;Fujii, Kenshi;Tsujimoto, Mari;Ichinohe, Tahei;Okabe, Saori;Hirooka, Keiji;Senshu, Yuna;Ohta, Tetsuro;Hayashi, Tomomi;Kawai, Yusuke;Horio, Juri;Takaishi, Atsushi;Nakamura, Mikiko;Takatsu, Hiroyuki;Shiota, Tomoko;Maemura, Koji;Nishida, Momoyo;Shibata, Yoshisato;Nagashima, Kaori;Shibasaki, Taro;Takahashi, Nobue;Iseki, Harukazu;Otsuki, Kenichi;Matsuoka, Shunzo;Motoda, Kentaro;Higuchi, Yoshiharu;Hayasaki, Hiromi;Manita, Mamoru;Ito, Riyo;Suzuki, Masahiro;Fumikura, Kaori;Iwata, Hiroshi;Kinjo, Kaori;Takimoto, Eiki;Omori, Yuki;Yumoto, Kazuhiko;Yoshizawa, Jun;Izumi, Chisato;Hirase, Kanae;Higashiue, Shinichi;Ishibaba, Ayaka;Higashino, Yorihiko;Matsumura, Takuro;Iida, Hiroshi;Kowa, Kaya;Koga, Tokushi;Hatakeda, Tomomi;Atsuchi, Nobuhiko;Migita, Kana;Momiyama, Yukihiko;Fukuda, Yusuke;Fukue, Masataka;Uchida, Kouji;Saito, Katsumi;Iida, Sakiko;Fukamizu, Seiji;Harada, Junko;Takei, Yasuyoshi;Takano, Saori;Hata, Yoshiki;Sato, Arisa;Shimura, Yumi;Hirata, Shinko;Namiki, Atsuo;Ishida, Noriko;Michishita, Ichiro;Ishimoto, Tomomi;Usuda, Kazuo;Oomura, Akiko;Kinugawa, Koichiro;Sasaki, Rumi;Matsubara, Takao;Kidani, Hiromi;Awaji, Yoshifumi;Kaneno, Yoko;Yamashita, Kentaro;Suzuki, Masami;Fujita, Hiroshi;Mashida, Aya;Yamada, Takahisa;Hirai, Shintaro;Ichikawa, Minoru;Muromaki, Takae;Ohtani, Tomohito;Yamaguchi, Sachiyo;Furukawa, Yutaka;Takata, Mika;Baden, Masato;Kawasaki, Futoshi;Tashiro, Hideki;Kita, Yuko;Taki, Mizuri;Suzuki, Kuniko;Nakama, Kenji;Oota, Chiaki;Hibi, Kiyoshi;Shiono, Mizuho;Matoba, Satoaki;Kimura, Natsuki;Takahashi, Akihiko;Fujino, Megumi;Ide, Tomomi;Tanaka, Chiharu;Ueda, Osamu;Shimojima, Rieko;Kuramochi, Takehiko;Ando, Michiko;Onaka, Haruhiko;Maeda, Anri;Higami, Tetsuya;Nishibe, Ikumi;Abe, Mitsunori;Matsugi, Megumi;Ako, Junya;Yamamura, Kimiko;Ueda, Tomoya;Itokazu, Yuki;Sumii, Kotaro;Ichii, Kano;Shimizu, Masatoshi;Irikura, Megumi;Shimizu, Shigeo;Ayabe, Misa;Matsubara, Taku;Kaneko, Satoko;Koizumi, Tomomi;Watanabe, Keiko;Sakagami, Satoru;Kumaki, Mariko;Suzuki, Atsushi;Kawano, Tomoe;Katayama, Yusuke;Nakamura, Hiroko;Taguchi, Isao;Araki, Yuko;Higa, Nobuyoshi;Oshiro, Yasuka;Yahikozawa, Kumiko;Anzai, Shiori;Nunohiro, Tatsuya;Nishi, Daichi;Osaki, Shuichi;Tanaka, Yoshiaki;Kaneko, Masayuki;Noguchi, Kimiko;Watanabe, Noriaki;Oishi, Toru;Fuse, Koichi;Baba, Yukari;Kim, Ga-Eun;Jeong, Jin-Ok;Choi, Young-eun;Lee, Hae-Young;Hur, Eunjin;Kang, Seok-Min;Lee, WonMi;Kim, Kye Hun;Song, Jiyeon;Yoo, Byung-Su;Shin, Seonmi;Shin, Mi Seung;Oh, Hei Won;Kim, Eung Ju;Park, JinJu;Choi, Dong-Ju;Yoon, Eun ji;Yang, Dong Heon;Choi, JiHyeong;Choi, Jung-Hyun;Jeong, Hwayoung;Choi, Jin-Oh;Hyun, Seo Jin;Jo, Sang-Ho;Sujin, Lee;Jin, Dong Kyu;Jeon, Jiwon;Shin, Joon-Han;Na, Ji Sung;Kim, Dong-Soo;Oh, Eunryul;Ong, Tiong Kiam;Sulehan, Juriah;Che Hassan, Hamat Hamdi;Amni, Zati;Zainal Abidin, Siti Khairani;Ravinttiran, Kanaga Lakshimi;de los Rios Ibarra, Manuel Odin;Martinez Sanchez, Carlos Rodolfo;Ronquillo Ramirez, Diestefano;Salazar Gaytan, Abel;Gonzalez Sandoval, Carmen;Alcocer Gamba, Marco Antonio;Munoz Rosales, Wendy;Esturau Santalo, Ramon Miguel;Sanchez Mendoza, Yazmin;Mendez Machado, Gustavo Francisco;Hirata Avila, Haydea;Reyes Araiza, Raul;Ruiz Morales, Jaime;Escobedo de la Pena, Jorge;Villegas Lara, Beatriz;Lopez Rosas, Enrique;Meza Hernandez, Michelle;Chavez Michel, Jaime;Ruiz Rubio, Elena;Varela, Alberto;Hobé-Rap, Coriet;Lok, Dirk;Dommerholt, Rina;Swart, Henk;van Scheltinga, Catharina Terwisscha;van de Wal, Ruud;van Lieshout, Ilvy;Van der Meer, Peter;Branderhorst, Anja;Werner, Henri Albert;van Ruijven-Mastenbroek, Ivonne;Meijs, Matthijs F. L.;Oldenhof, Linnea;Den Hartog, Frank;Singerling, Margreeth;Troughton, Richard William;Rose, Stephanie;Hamilton, Fraser;Jacques, Sharon;Ferrier, Katherine;Kovacs, Jo-Anne;Lund, Mayanna;Pearce, Lynette;Doughty, Robert;Terbals, Mariska;Amir, Nezar;Hulbert, Cathy;Pemberton, James;Scott, Deborah;Nilsen, Dennis;Nilsen, Jorunn;Gullestad, Lars;Bjorklund, Elisabeth;Claussen, Hege;Keilegavlen, Havard;Faalun, Nina;Ruddox, Vidar;Pedersen, Annbjoerg;German Rodriguez Escudero, Aldo Edwin;Romero, Sonia;Orihuela, Boris;Del Portal, Monica;Rodriguez, Victor Elias;Cabanillas Gallo, Nurys;Medina, Felix Alvaro;Rodriguez, Jeanneth;Lu Galarreta, Libia;Espejo, Jill;Matta, Milagros;Salvador, David Raymund K.;Cudiamat, Wendy Lynn;Reyes, Eugene;De Guzman, Susan;Sy, Rody;Silva, Claudette;Brillantes, Amelita;Alon-Alon, Amy;III, Gabriel Jocson;Cortez, Frances Joyce;Tirador, Louie S.;Gamboa, Charity Daine A.;Habaluyas, Ramoncito S.;Incognito, Mary Jane;Szachniewicz, Joanna;Nawrocka-Millward, Sylwia;Goch, Aleksander;Lugowski, Tomasz;Nessler, Jadwiga;Czubek, Urszula;Straburzynska Migaj, Ewa;Przepiora, Agnieszka;Pijanowski, Zbigniew;Pijanowska, Monika;Kasprzak, Jaroslaw;Mirek-Bryniarska, Ewa;Zareba, Wojciech;Musial, Wlodzimierz;Tycinska, Agnieszka;Miekus, Pawel;Przydatek, Justyna;Krysiak, Waldemar;Skorek, Edyta;Leszek, Przemyslaw;Polaska, Paula;Skonieczny, Grzegorz Krzysztof;Roliard, Monika;Wujkowski, Marek;Strupiechowski, Mariusz;Diago, Maria;Baez, Julio;Casanova-Jimenez, Lusdian;Zayas-Torres, Carlos R.;Duran, Aleja;Colon-Hernandez, Pedro J.;Carrasquillo, Merari;Rios Bonilla, Maria L.;Marcano, Magaly;Garcia-Gordo, Pedro;Navedo-Santos, Jessenia;Boldueva, Svetlana;Shvets, Natalia;Orlova, Natalia;Klepikova, Maria;Kastanayan, Alexander;Babaeva, Leily;Meray, Imad;Teterina, Marina;Shvarts, Yury;Konshina, Larisa;Yakushin, Sergey;Filippov, Evgeniy;Sayganov, Sergey;Nikolaev, Dmitry;Vishnevskiy, Alexander;Zykov, Vladislas;Solovev, Oleg;Nazarov, Dmitry;Bolshakova, Olga;Polunicheva, Ekaterina;Treshkur, Tatiana;Berngardt, Edvard;Nosov, Vladimir;Koroleva, Lubov;Kamalov, Gadel;Urazaeva, Liliya;Ilyukhin, Oleg;Morozov, Evgeny;David Sim, Kheng Leng;Lee, Yuen Yet;Lee, Shao Guang Sheldon;Tang, Xuan;Soon, Dinna Kar Nee;Lim, Boon Khim;Wong, Raymond CC;Wong, Cher Yi;Loh, Seet Yoong;Cheng, Geok;Tan, Geraldine;Abelson, Mark Jonathan;King, Annusca;Bayat, Junaid;Badat, Katija;Ranjith, Naresh;Ramdas, Shavina;Nunkoo, Theema;Prozesky, Hans Walter;Naude, Christina;Fulat, Muhammed Ameen;Pretorius, Michelle;Ntsekhe, Mpiko;Mtana, Noloyiso;Klug, Eric Q;Naidoo, Vaman;Pillay-Ramaya, Larisha;Phillips, Sharon;Makotoko, Ellen Makoali;Page, Andonia;Malahleha, Moelo;Pitsoane, Mosidi;Mediavilla Garcia, Guiomar;Gonzalez Juanatey, Jose Ramon;Seijas Amigo, Jose;Martínez-Sellés, Manuel;Sobrino González, Olga;González-Ferrer, Eduardo;González, Paz;Manito Lorite, Nicolas;Guerrero, Sonia;Farré López, Núria;Soler Ayat, Cristina;Gomez Doblas, Juan Jose;Robles, María;Núñez, Julio;Mollar Fernández, Anna;Gómez Bueno, Manuel;González Segovia, Ariadna;Lund, Lars;Hultman-Cadring, Ann;Pol, Tymon;Langoe, Annika;Hansen, Ole;Nake, Else;Danyi, Tamas;Kruse, Anna-Karin;Magnusson, Christer;Palo, Ninve;Fu, Michael;Fahlen, Kim;Bollano, Entela;Westlund, Ann-Christin;Hullin, Roger;Salzmann, Sandrine;Moccetti, Tiziano;Serra, Anna;Mueller, Christian;Flores, Dayana;Lin, I-Chen;Hwang, Juey-Jen;Chen, Yi-Chun;Chang, Wei-Ting;Su, Shu-Fen;Chao, Ting-Hsing;Tseng, Wen-Hui;Wu, Yen-Wen;Chen, Yung-Cheng;Liu, Ming-En;Chou, Vinny;Cavusoglu, Yuksel;Yilmaz, Mehmet Birhan;Sansoy, Vedat;Sahin, Tayfun;Sezer, Murat;Celik, Ahmet;Oto, Mehmet Ali;Tengiz, Istemihan;Reshotko, Oksana;Donets, Oleksandra;Rybachok, Yuliia;Sychov, Oleg;Romanova, Olena;Kulbachuk, Oleksandr;Klitsunova, Yuliia;Velichko, Natalia;Tomakh, Nataliia;Squire, Iain;Fisher, Judith;Bethell, Hugh;Howard, Emma;Barr, Craig Scott;Dean, Julie;Clark, Andrew;Bulemfu, Jeanne;Cooke, Justin;Whileman, Amanda;Davies, Ceri;Pheby, Jane;McDonagh, Theresa;Breeze, Jonathan;Wong, Kenneth;Fleming, Catherine;Amin, Jay;Cervoni, Theresa;Aslam, Shamaila;Burns, Dawn;Bank, Alan J.;Gernes, Nicole;Bedwell, Noel W.;Craig, Mary;Iteld, Bruce J.;Ocman, Brandy;Bhalla, Rajinder;Hicks, Teresa;Chu, A. Alan S. P.;Nguyen, Susan;Feldman, James;Peek, Madeline;George, Ferris;Baker, Christine;Gray, Wayne L.;Adair, Sherry;Jetty, Preetham;Key, Alyssa;Kazemi, Navid;Hollis, Suzette;Larned, Joshua;Ortiz, Mara-Li;Smith, Janet L;Abell, Tina;Cadaret, Linda;Larew, Cynthia;Long, Robert;Hickey, Theresa;Mahal, Sharan S.;Yandamuri, Sivaradhika;Whellan, David J.;Schwegler, Daniel;McCullough, Peter;Baker, Rebecca;McGinty, John;Fry, Nancy;Pelzel, Jamie M.;Douvier, Ashley;Vilaro, Juan;Long, Sarah;Perlman, Richard;Hoopes, Donna;Podugu, Ramana;Smith, Kathleen;Rahko, Peter;Olsen, Karen J.;Ravichandran, Ashwin;Reilly, Bonnita;Sangrigoli, Renee;Schwarz, Linda;Greene, Trevor O;Jackson, Cathy;Davis, Teleah;Spiller, Dennis;Ferrin, Smelda;Viswanath, Dilip B.;Manga, Sue;Xu, Zi Jian;Holmes-Rees, Deborah;Bittrick, Jon M.;Calhoun, Ericka;Ewald, Gregory Alan;Bult, Karen;Farr, Maryjane;Kim, Andrea;Forgosh, Les;Riestenberg-Smith, Joyce;Jaffrani, Naseem;Childers, Rebecca;Brinkley, Douglas Marshall;Carroll, Amanda;McLean, Dalton S.;Pruitt, Hugh;Lewis, Greg;Cocca-Spofford, Diane;Snyder, Harvey A.;Pantuck, Louise;Teufel, Edward J.;Glasgow, Brenda;Donovan, Daniel J.;Alvarado-Garcia, Maria Magdalena;Dauber, Ira;Derbyshire, Susan;Zavaro, Suhail;Miller, Aolani;Sharkey, Kevin;Ferguson, Alanza;Adams, Kirkwood;Glotzer, Jana;Perez, Jose A;Addington, Jodie;Bhatti, Zulfiquar;Burton, Carla;Melucci, Mike B.;Meier, Susan;Huber, Michael;Anazawa, Fujiko;Upshaw, Jenica;Carr, Katelyn;Holmberg, Mark Jeffrey;Rasmussen, Lois S.;Lucarella, Vanessa J;Maloney, Kathleen;Sabatino, Kenneth C.;Everett, John;Kelley, Emily;Murthy, Sandhya;Camillo, Angeline;Sweitzer, Nancy;Schrag, Cindy;Carson, Peter E.;Gannuscio, Jacqueline;Lewis, Neil Pendril;Chafin, Krista;Miller, Alan Bruce;Richardson, Erin;Qayyum, Usman;Brown, Paige;Singal, Dinesh;Giunta, Danielle;Krishnamoorthy, Arun;Vallabh, Reema;Keller, Andrew J;Burton, Stephanie;Adler, Alexander;Thompson, Dean;Stehlik, Josef;Hong, Jennifer;Luckasen, Gary J.;Kaczkowski, Scott;Old, Wayne;Bullivant, Melinda;Boehmer, John;Gardner, Kevin;Gupta, Dinesh K.;Davey, Tammy;Mehta, Hirsch;Ciezkowski, Gina;Hong, Michael;Hejna, Elizabeth;Guha, Ashrith;De Oliveira, Marcos;Haddad, Tariq;Overbeck, Deanna;Taheri, Hamid;Elie, Abbey;Dumitru, Ioana;Guedes, Ricardo;Heroux, Alain;Kartje, Carol;Zughaib, Marcel E.;Edillo, Candice;Link, Chad;Boak, Jennifer;Darlington, Andrew;Kaszonyi, Kathryn;Sloan, Stephen B.;Wood, Deborah;Jundi, Mayar;Ostrander, Ann;Khosla, Sandeep;Lukka, Sudha;Williams, Marcus L.;Michel, Kimberly;Artis, Andre;Armstrong, Kimberly;Kondo, Nicholas;Kostedt, Gretchen;Galtes, Israel;Diaz, Yasnhai;Martinez, Luis;Penafiel, Beatriz;Cardona, Jose F.;Juarez, Abril;Abdullah, Shuaib;Atwell, Amy;Sharf, Albert J.;Cortes, Leonardo;Bhagwat, Ravi;Winterrowd, Donna;Michael Donath, Elie;Ycaza, Maria;Jones, Alonzo;Gillespie, Eve;Keane-Richmond, Pat;Becker, Richard;Mardis, Rachel;Fail, Peter S.;Parfait, Vicky;Ayalloore, Siby;Rideaux, Tessie;May, Wade;Zannini, Julie;Chugh, Atul R.;Alford, Stephanie;Alhaddad, Mohsin;Holman, Lani;Strader, Russell J.;Gneiting, Alicia;Wells, Terry;Smith, Jessica;Young, Vernon;Buchanan, Cynthia;K Singla, Ish;Roth, Justin;Ooi, Henry;Diedrich, Laura;Colfer, Harry T.;Antonishen, Denise;Romero Zarante, Angela;Zambrano, Yenisca;Hominal, Miguel;Suarez, Martin;Vottero, Ezequiel;Lopez, Marcia;Montaña, Oscar;Cendali, Gloria;Vico, Marisa;Giozzi, Erica;Aizenberg, Diego;Coussio, Santiago;Arakaki, Diego;Gelersztein, Miriam;McKenzie, Scott;Stibilj, Kathryn;Colquhoun, David;Macdonald, Gemma;Atherton, John;Lilwall, Lydia;De Pasquale, Carmine;Thomas, Simeoni;Chan, Alicia;Healy, Denise;McQuillan, Brendan;Beer, Natalya;von Lewinski, Dirk;Rausch, Viktoria;Schober, Andreas;Leitgeb, Maria-Christine;Adlbrecht, Christopher;Koehler, Cordula;Auer, Johann;Rossmaier, Manuela;Mirna, Moritz;Kopp, Kristen;Saraiva, Jose;Vicente, Carla Cristina;Schwartzmann, Pedro;Ilana, Gabriela;Freitas, Aguinaldo;Costa, Sandra;Moura, Lidia;de Liz, Fernanda;Mourilhe Rocha, Ricardo;Coelho, Roberta;Marcondes-Braga, Fabiana;Antunes, Talita;Simoes, Marcus;Silva, Veronica;Souza, Joao;Freire, Grazielle;Silveira, Fábio;Galvão, Tamyres;Manenti, Euler;Silva, Carollainy;Bourgeois, Ronald;Boyd, Karen;Huynh, Thao;Boudreault, Caroline;Hartleib, Michael;Otis, Rebecca;Cha, James;Otis, Judy;Heffernan, Michael;Birch, Marie;Pandey, A. Shekhar;Armstrong, Samantha;Mukherjee, Ashok;Zakria, Lubna;Parent, Marie-Claude;Brown, Helene;Hayami, Doug;Keller, Deborah;Schaffer, Stephen Allan;Janz, Wendy;Pesant, Yves;Sardin-Laframboise, Yanick;Kushnerik, Quentin;Roy, Annie;Gosselin, Gilbert;Leblanc, Nathalie;Khaykin, Yaariv;Nemtean, Debbie;Moe, Gordon;Fernando, Carlos;Sia, Ying;Bujold, Amelie;Howlett, Jonathan;Sasikumar, Anusha;Swiggum, Elizabeth;Lounsbury, Noreen;Lepage, Serge;Fortier, Carl;Verma, Subodh;Chen, Debbie;Lanas, Fernando;Figueroa, Pamela;Maluenda, Gabriel;Vergara, Maria;Prieto, Juan;Noriega, Viviana;Morales, Luis;Zapata, Jessica;Yovaniniz, Patricio;Grandon, Marcela;Appiani, Franco;del Rio, Tatiana;Mellado, Sergio;Alvarez, Claudia;Cruz, German;Mino, Sebastian;Palma Carvajal, Juan Carlos;Olguin, Veronica;Bourke, Paz;Toledo Grell, Maribel;Marin, Hugo;Rios, Sebastian;Novajas, Manuel;Carcamo Medina, Macarena;Zhou, Jingmin;Lu, Mingfeng;Chen, Jiyan;Jiang, Yihan;Wang, Junkui;Kang, Yuhong;Jiang, Luping;Zhong, Yuxin;Jin, Wei;Jin, Shanshan;Dong, Jianzeng;Wang, Jiajia;Peng, Jianqiang;Peng, Xiaomei;Hou, Aijie;Duan, Ruili;Jiang, Weihong;Zhou, Xiaowei;Gu, Xiang;Dai, Wenjuan;Mei, Yibin;Liu, Miaoxia;Yu, Jing;Chen, Jinxia;Yuan, Zuyi;Shen, Aidong;Wang, Yutao;Zhao, Ruiping;Ren, Peiyan;Yao, Zhuhua;Zhang, Xiying;Wang, Jingfeng;Ouyang, Huijun;Chen, Maohua;Lu, Yu;Miao, Peizhi;Chen, Zhenfei;Huang, Zhouqing;Teng, Xiaoli;Wang, Jiahong;Yan, Xuyao;Xu, Biao;Gao, Yue;Qiao, Ping;Han, Mizozhu;Liu, Mingya;Wu, Shaorong;Li, Ruihao;Liang, Qian;Ni, Zhengzheng;Ma, Qilin;Li, Ting;Cong, Hongliang;Zhu, Chuangting;Li, Guangping;Liu, Lin;Li, Weimin;Jing, Junsheng;Zhang, Qing;Tang, Jia;Zhao, Cuimei;Ting, Liao;Hu, Xiaosheng;Fang, Yao;Yin, Yuehui;Liu, Xuejun;Jiang, Jun;Zhang, Mengqing;Luo, Yuanyuan;Wang, Siqi;Zhang, Ping;Zhang, Peng;Wu, Yanqing;Wei, Wenting;Pang, Xiaohua;Xia, Yanqiong;Wang, Lihong;Lv, Chenyu;Fang, Zhihua;Du, Qiaochu;Yang, Ping;Liu, Xuejiao;Yuan, Wei;Wang, Min;Huang, Kai;Xiang, Danli;Ma, Likun;Liu, Jinxiu;Garcés Restrepo, Claudia;Accini, Jose;Conrado Ortega, Yineth;Botero, Rodrigo;Caceres, Aleydy;Cadena, Alberto;Martinez, Jessica;Moncada Corredor, Miguel;Florez, Leisa;Arana, Camilo;Diaz Villegas, Lizzette;Molina de Salazar, Dora;Valencia, Maria;Carvajal, Juan;Delgado, Paola;Echeverria, Luis;Bueno Diaz, Karen;Gomez-Mesa, Juan;Trujillo, Laura;Echeverry, Eduardo;Escruceria, Adriana;Reyes Dia, Melissa;Cervantes Hurtado, Adriana;Busak, Ladislav;Pokorna, Blanka;Melenovsky, Vojtech;Kuprova, Anna;Hajsl, Martin;Brindova, Jana;Miklik, Roman;Musilova, Veronika;Nechvatal, Libor;Radvan, Martin;Machova, Renata;Belohlavek, Jan;Zavadilova, Petra;Monhart, Zdenek;Bouzkova, Lenka;Drasnar, Tomas;Fald, Matej;Bolvanska, Nora;Packova, Helena;Krejci, Jan;Roche, Jana;Hove, Jens;Ring, Lotte;Lindhardt, Morten;Bang-Hansen, Therese;Due Lomholdt, Jens;Niemann, Kari;Madsen, Kristian;Hummelshoej, Joan;Egstrup, Kenneth;Hindsgaul, Linda;Schou, Morten;Madsen, Jette;Nielsen, Søren;Jakobsen, Emilie;Wiggers, Henrik;Leth, Marianne;Kober, Lars;Eriksen, Elsebet;Eske Bruun, Niels;Kragh, Winnie;Bronnum-Schou, Jens;Hadsund, Pia;Vadmann, Henrik;Nielsen, Annette;Galinier, Michel;Rosolin, Nathalie;Tartiere, Jean-Michel;Armangau, Pauline;Ferrari, Emile;Belkacem, Nassima;Aludaat, Cadi;Balaya-Gouraya, Line;Berthelot, Emmanuelle;Pezzi, Agnes;Girerd, Nicolas;Tachot, Emilie;Dutoiu, Teodora;Derien, Anne-Sophie;Boiffard, Emmanuel;Prunier, Philippe;Picard, Francois;Moumni, Manel;Isnard, Richard;Tabdjoun, Ghoulem;Mewton, Nathan;Barry, Bianca;Geissler, Arne;Schumacher, Jeanette;Schwimmbeck, Peter;Krug-Hoeren, Bianca;Dimitroulis, Dimitrios;Simons, Judith;Sinning, Jan-Malte;Müller, Julia;Duersch, Martin;Leyh, Daniela;Wied, Elisa;Overhoff, Ulrich;Rupprecht, Mariana;Lindemann, Hannes;von Hertell, Ines;Rieker, Werner;Anacker, Jelena;Ebelt, Henning;Goebel, Ute;Jabs, Alexander;Kirchenwitz, Stephanie;Mahnkopf, Christian;Hahn, Mario;Bergmann, Martin;Bosredon, Cecile;Brudzinski, Mirko;Steinbruegger, Katja;Linke, Axel;Eck, Kerstin;Beug, Daniel;Gonzalo de Juan, Maria;Schadow, Kerstin;Schaefer, Nicole;Frey, Norbert;Schafer, Benjamin;Bauersachs, Johann;Markakis, Alexandros;Eberhard, Katrin;Karmpalioti, Maria;Tziakas, Dimitrios;Kesoglou, Vaggelitsa-Eirini;Tsioufis, Konstantinos;Gkartzonikas, Ilias;Patsilinakos, Sotirios;Karagogou, Pinelopi;Naka, Aikaterini;Nikolopoulos, Petros;Skoularigkis, Ioannis;Ereliadou, Foteini;Filipatos, Gerasimos;Lathridou, Paraskevi;Ninios, Vlasios;Androutsou, Evangelia;Karvounis, Haralampos;Moutafi, Vasiliki;Briasoulis, Alexandros;Mandila, Christin;Tsougos, Elias;Garcia de Krumbach, Lissette;Karavidas, Apostolos;Aguilar Schinini, Mayra;Arango Benecke, Juan;Ramírez Ávila, Andrea Lucia;Montenegro Valdovinos, Pablo;Ting Wang, Xue;Rodas Diaz, Marco;San Lui Ho, Venus;Lee, Pui-Wai Alex;Tam, Eva;Hai, Siu Han Jojo;Lee, Kar Wai;Fan, Katherine Yue Yan;Nagy, Zsolt;Chan, Ngai-Yin;Rozsa Toth, Karolyne;Kancz, Sandor;Toth, Krisztina;Kirschner, Robert;Kósa-Hóbor, Laura;Lakatos, Ferenc;Bartha, Barna;Merkely, Bela;Bencze, Gabriella;Papp, Andras;Kiss, Gabor;Zilahi, Zsolt;Kovacs, Szilvia;Kovacs, Istvan;Levang, Szilvia;Toth, Tunde;Nagy, Monika;Habon, Tamas;Kónyi, Réka;Takacs, Janos;Hadi, Nora;Konyi, Attila;Spandli, Katalin;Benczur, Bela;Szabone Nagy, Maria;Literati-Nagy, Botond;Kormanyos, Arpad;Nagy, Andras;Ibolya Mihaly, Gyongyver;Sepp, Robert;Kalapos, Anita;Noori, Ebrahim;Mayene Abalos, Jan;Thury, Attila;Maher, Joanne;Murphy, Ross;Nabwani, Neda;McDonald, Kenneth;Even Nir, Hadas;Atar, Shaul;Paor, Galit;Ben Gal, Tuvia;Biener, Meital;Caspi, Oren;Yedid Am, Shiree;Goland, Sorel;Elber, Jenny;Hasin, Tal;Lapidus, Ira;Mohsen, Jameel;Barhum, Dema;Moravsky, Gil;Swisa, Sapir;Zwas, Donna;Eizenberg, Nava;Goldman, Alexander;Ambrosio, Marilisa;Fardman, Alexander;Punzo, Noemi;Mattavelli, Irene;Fucili, Alessandro;Assoni, Luca;Agostoni, Piergiuseppe;Morsella, Valentina;Nodari, Savina;Maffi, Marta;Volterrani, Maurizio;Gallelli, Ilaria;Scelsi, Laura;Algeri, Michela;Borghi, Claudio;Famiani, Roberta;Maloberti, Alessandro;Ramani, Federica;Carugo, Stefano;Vannuccini, Francesca;Sinagra, Gianfranco;Scapicchi, Caterina;Palazzuoli, Alberto;Cuccuru, Giuditta;Ambrosio, Giuseppe;D'Alessandro, Francesca;De Ferrari, Gaetano;Suhaimi, Manhaiyun;Badagliacca, Roberto;Sulehan, Juriah;Zainal Abidin, Imran;Mohd Bukhari, Fatma Diyana;Ong, Tiong Kiam;Alia, Nur;Siti, Khairani;Abidin, Zainal;Tiew, Neoh Poh;Raja, Shariff;Faridz Shariff, Ezman;Mamat, Zalida;Syukur Abdullah, Abd;Wong, Mabelle;Isa, W;Yus Haniff, W;Suhaili Mamat, Nurul;Liew, Houng Bang;Hirata Avila, Haydea;Wazi Ramli, Ahmad;Aguilar Sanchez, Ma.;Mendez Machado, Gustavo;Guzman Solorzano, Hannah;Arenas León, José;Meza Hernandez, Michelle;Arias Mendoza, Maria;Flores Pruneda, Rosa;Lopez Rosas, Enrique;Castro Zarate, Carlos;Bazzoni Ruiz, Alberto;Ramos Ruiz, Ana Rosa;Perez Rios, Jesus;de la Vega, Lucia;Segura Gonzalez, Armando;Mendez, Wendy;Gandoy Vazquez, William;Garcia Gonzalez, Luz Belen;Peralta Rosado, Hilda;Maytorena, Maria;Varela Varela, Alberto;Ruiz Rubio, Elena;Vazquez, Paul;Goiz, Nazareth;Chavez Michel, Jaime;Lopez, Claudia;Fajardo Campos, Pedro;del Muro Munoz, Sergio;Illescas Diaz, Jesus;Medina Reyes, America;Garcia, Ricardo;Cuevas, Araceli;Salazar Lopez, Hector;García Briones, Ana;Matadamas, Norberto;Barcenas, Edgar;Vargas, Castelán;Astorga Rivas, Marcos;Bayram Llamas, Edmundo;Olguin Ortiz, Felipe;Payro, Gerardo;González, Geraldine;Zambrano Ruiz, Eduardo;Rodriguez Cal Y Mayor, Arianna;Ricalde, Alejandro;Rose, Stephanie;Ramirez Mendoza, Marcelo;Kovacs, Jo-Anne;Troughton, Richard;Scott, Deborah;Ferrier, Katherine;Jaques, Sharon;Pemberton, James Pemberton;Hulbert, Cathy;Dhakshinamurthy, Vijay;Duckworth, Jamie;Amir, Nezar;Kistanna, Danica;Turaga, Mansi;Romero, Sonia;Benatar, Jocelyne;Rodriguez, L. Jeanneth;Rodriguez Escudero, Aldo Edwin;Espejo, Jill;Medina Palomino, Felix;Ariza Villanueva, Carola;Lu Galarreta, Libia;Matta, Milagros;Cabrera, Jose;Zena, J.;del Rosario, Norma;Godoy Palomino, Armando;Garcia, Maria;Correa, Roger;Castillo, Leonila;Berrospi, Percy;Gil Rescavarren, Maria;Cardoza Anton, Luisa;Chromczak, Bozena;Camacho Cosavalente, Luis;Idzikowska, Paulina;Pijanowski, Zbigniew;Wilczynska, Joanna;Skoczylas, Grzegorz;Tunkiewicz, Monika;Pawlowicz, Lidia;Cieszynska, Alina;Szachniewicz, Joanna;Zajdel, Wojciech;Cymerman, Krzysztof;Polak, Agnieszka;Augustyn, Marta;Zurakowski, Aleksander;Ryznar-Sicinska, Anna;Witek, Robert;Markiewicz, Natalia;Mazur, Stanislaw;Beme, Anna;Lugowski, Tomasz;Walasek, Pawel;Miklaszewicz, Beata;Matys, Urszula;Gniot, Jacek;Rolirad, Monika;Sudnik, Wanda;Bartoszewska, Dorota;Skonieczny, Grzegorz;Camacho-Molina, Airleen;Prokopczuk, Janusz;Molina Elicier, Brenda;Toro-Grajales, Ismael;Vazquez-Tanus, Jose;Torres-Rivas, Noemi;Matta Fontanet, Evelyn;Alcocer Rodriguez, Loriany;Figueroa-Torres, Yolanda;Zhernokleev, Andrei;Rodriguez-Ospina, Luis;Konshina, Larisa;Vishnevskiy, Alexander;Teterina, Marina;Shvarts, Yury;Volkova, Elena;Meray, Imad;Ledyaeva, Alla;Bolshakova, lga;Evtushenko, Oxana;Lopatin, Yury;Peregudova, Natalia;Kastanayan, Alexander;Solnyshkov, Sergey;Yakushin, Sergey;Garina, Irina;Shutemova, Elena;Khaisheva, Larisa;Kraeva, Irina;Koziolova, Natalya;Kizhvatova, Natalia;Kositsyn, Dmitry;Yakovleva, Elena;Kosmacheva, Elena;Dronov, Dmitry;Lukyanov, Yury;Sorokina, Olga;Samodurova, Anna;Isaeva, Elena;Trukshina, Maria;Kovalchuk, Evgeniy;Ustiuzhanin, Nikloai;Sitnikova, Maria;Febriana, Eveline;Zykov, Mikhail;Chua, Xin Tian;Sim, Kheng Leng David;Ang, Kah Min;Loh, Seet Yoong;Fuad, Siti Norashikin Binte;Lin, Weiqin;van der Mescht, Marelize;Huang, Weiliang;Pretorius, Michelle;Burgess, Lesley;Greyling, Louwra;Ameen Fulat, Muhammad;Mtana, Noloyiso;Makotoko, Ellen;Katisi, Deborah;Ntsekhe, Mpiko;Mosia, Nozibusiso;Nunkoo, Theema;Naidoo, Vaman;Mngqibisa, Rosie;van Vuuren, Sonnika;Klug, Eric;Madavha, Unarine;Mohamed, Zarinah;Nortje, Engela;Rheeder, Paul;Jacovides, Tracy;Arnold, Susan;Stuurman, Chano;Jacovides, Andrew;Faul, Catharina;Coetzee, Kathleen;Mohamed, Zakariyyaa;De Jong, Douwe;Park, Seul Gi;Dawood, Riaz;Lee, WonMi;Cho, Myeong-Chan;Jeong, Hwayoung;Kang, Seok-Min;Lee, Ryeong Gyeong;Choi, Jung-Hyun;Jeong, Jin-Ok;Kim, Eun;Yoo, Byung-Su;Park, Boram;Jo, Sang-Ho;Chae, Gaeul;Chung, Wook-Jin;You, MiJu;Cho, Hyun-Jai;Rodriguez Penas, Diego;Kim, Kye Hun;Carrasco Ossorio, Catalina;Reyes Dominguez, Antonio;Martinez Jaen, Ruben;Nunez Villota, Julio;Viaplana, Judith;Ferreira, Ignacio;Sicilia Bravo, Isabel;Comin-Colet, Josep;Gonzalez Portilla, Paz;Goirigolzarri Artaza, Josebe;Soler, Cristina;Alvarez Garcia, Jesus;Gastelurrutia, Paloma;Mediavilla Garcia, Guiomar;Bayes Genis, Antoni;Grille Cancela, Zulaica;Lopez de Sa Areses, Esteban;From, Kristina;Generosa Crespo Leiro, Maria;Haglund, Pernilla;Bergh, Niklas;Broberg, 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Schuyler;Alexander, Karen;Al-Khatib, Sana;Gutierrez, Jorge;Harrison, Robert;Kittipibul, Mark;Kolls, Bradley;Kong, David;Lerman, Joseph;Matthews, Robert;McGarrah, Robert;Mehta, Rajendra;Povsic, Thomas;Rymer, Jennifer;Sasannejad, Cina

2025

Abstract

Background: Following completion of the VICTORIA trial, vericiguat was approved for the treatment of worsening heart failure with reduced ejection fraction (HFrEF) and received a class IIb recommendation in European and North American guidelines. The subsequent VICTOR trial evaluated the use of vericiguat in patients with HFrEF and no recent worsening. We aimed to assess the effect of vericiguat on clinical endpoints through pooled analyses of patient-level data from the VICTORIA and VICTOR trials. Methods: This prespecified, pooled individual participant-level analysis was conducted on data from two trials: VICTORIA, which was active from Sept 25, 2016, to Sept 2, 2019 in 42 countries, and VICTOR, which was active from Nov 2, 2021, to Feb 5, 2025 in 36 countries. The VICTORIA trial enrolled adult (aged ≥18 years) participants with HFrEF with recent worsening (defined as either hospitalisation for heart failure within the previous 6 months or outpatient use of intravenous diuretics within the previous 3 months) and increased NT-proBNP concentrations; the VICTOR trial had similar eligibility criteria but participants had no recent worsening of heart failure. Participants in both trials received contemporary background guideline-directed heart failure therapy as appropriate. The primary endpoint was a composite endpoint of cardiovascular death or hospitalisation for heart failure (also assessed individually). This study is registered with PROSPERO, CRD420251065636. Findings: Data from 11 155 patients (5050 in the VICTORIA trial and 6105 in the VICTOR trial) were included in the pooled analysis. The primary endpoint of cardiovascular death or hospitalisation for heart failure occurred in 1446 (25·9%) of 5579 patients in the vericiguat group and 1556 (27·9%) of 5576 patients in the placebo group (hazard ratio [HR] 0·91 [95% CI 0·85-0·98]; p=0·0088), with similar reductions in its individual components of cardiovascular death (0·89 [0·80-0·98]; p=0·020) and hospitalisation for heart failure (0·92 [0·84-1·00]; p=0·043) as first events. Interpretation: Vericiguat reduced the risk of hospitalisation for heart failure and cardiovascular death in patients with HFrEF across a broad range of clinical severity, including those receiving contemporary guideline-directed medical therapy. Vericiguat might be suitable as an additional treatment option for selected patients with HFrEF. Funding: Merck Sharp & Dohme (a subsidiary of Merck) and Bayer.

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	Settori scientifico-disciplinari dell'articolo (validi dal 09/05/2024)
	
				Settore MEDS-07/B - Malattie dell'apparato cardiovascolare
			
	Data di pubblicazione
	
				2025
			
	Data ahead of print o data di stampa
	
				30-ago-2025
			
	Rivista in ANCE
	
				THE LANCET
			
	DOI
	
				https://dx.doi.org/10.1016/s0140-6736(25)01682-4
			
	Tipologia
	
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				01 - Articolo su periodico

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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/2434/1181919

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