This review explores the potential of microRNAs (miRNAs) as diagnostic and therapeutic targets to enhance control programs for cystic echinococcosis (CE), a zoonotic parasitic disease posing significant threats to global human and animal health. Scientific evidence has demonstrated that Echinococcus-derived miRNAs are present in the biofluids of infected hosts, underscoring their potential for CE diagnosis. Additionally, specific miRNAs from Echinococcus granulosus sensu lato have been shown to influence host–parasite interactions, making them promising therapeutic targets for CE. In conclusion, further investigation into the role of miRNAs in CE could lead to significant breakthroughs in the fight against this neglected disease.
Unlocking the potential of miRNAs in cystic echinococcosis / P. Pepe, E. Ciccone, N.A. Cacciola, C. Bazzocchi, L. Rinaldi. - In: TRENDS IN PARASITOLOGY. - ISSN 1471-4922. - 41:(2025 Aug), pp. 8.685-8.698. [10.1016/j.pt.2025.06.004]
Unlocking the potential of miRNAs in cystic echinococcosis
C. BazzocchiPenultimo
;
2025
Abstract
This review explores the potential of microRNAs (miRNAs) as diagnostic and therapeutic targets to enhance control programs for cystic echinococcosis (CE), a zoonotic parasitic disease posing significant threats to global human and animal health. Scientific evidence has demonstrated that Echinococcus-derived miRNAs are present in the biofluids of infected hosts, underscoring their potential for CE diagnosis. Additionally, specific miRNAs from Echinococcus granulosus sensu lato have been shown to influence host–parasite interactions, making them promising therapeutic targets for CE. In conclusion, further investigation into the role of miRNAs in CE could lead to significant breakthroughs in the fight against this neglected disease.| File | Dimensione | Formato | |
|---|---|---|---|
|
Figure 1_revised version1.pdf
embargo fino al 01/09/2026
Tipologia:
Post-print, accepted manuscript ecc. (versione accettata dall'editore)
Licenza:
Creative commons
Dimensione
261.29 kB
Formato
Adobe PDF
|
261.29 kB | Adobe PDF | Visualizza/Apri Richiedi una copia |
|
Figure I_revised v2.pdf
embargo fino al 01/09/2026
Tipologia:
Post-print, accepted manuscript ecc. (versione accettata dall'editore)
Licenza:
Creative commons
Dimensione
309.81 kB
Formato
Adobe PDF
|
309.81 kB | Adobe PDF | Visualizza/Apri Richiedi una copia |
|
Pepe+et+al._clear+revised+version.pdf
embargo fino al 01/09/2026
Tipologia:
Post-print, accepted manuscript ecc. (versione accettata dall'editore)
Licenza:
Creative commons
Dimensione
275.34 kB
Formato
Adobe PDF
|
275.34 kB | Adobe PDF | Visualizza/Apri Richiedi una copia |
|
1-s2.0-S1471492225001576-main(1).pdf
accesso riservato
Tipologia:
Publisher's version/PDF
Licenza:
Nessuna licenza
Dimensione
867.8 kB
Formato
Adobe PDF
|
867.8 kB | Adobe PDF | Visualizza/Apri Richiedi una copia |
Pubblicazioni consigliate
I documenti in IRIS sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.




