This review explores the potential of microRNAs (miRNAs) as diagnostic and therapeutic targets to enhance control programs for cystic echinococcosis (CE), a zoonotic parasitic disease posing significant threats to global human and animal health. Scientific evidence has demonstrated that Echinococcus-derived miRNAs are present in the biofluids of infected hosts, underscoring their potential for CE diagnosis. Additionally, specific miRNAs from Echinococcus granulosus sensu lato have been shown to influence host–parasite interactions, making them promising therapeutic targets for CE. In conclusion, further investigation into the role of miRNAs in CE could lead to significant breakthroughs in the fight against this neglected disease.

Unlocking the potential of miRNAs in cystic echinococcosis / P. Pepe, E. Ciccone, N.A. Cacciola, C. Bazzocchi, L. Rinaldi. - In: TRENDS IN PARASITOLOGY. - ISSN 1471-4922. - 41:(2025 Aug), pp. 8.685-8.698. [10.1016/j.pt.2025.06.004]

Unlocking the potential of miRNAs in cystic echinococcosis

C. Bazzocchi
Penultimo
;
2025

Abstract

This review explores the potential of microRNAs (miRNAs) as diagnostic and therapeutic targets to enhance control programs for cystic echinococcosis (CE), a zoonotic parasitic disease posing significant threats to global human and animal health. Scientific evidence has demonstrated that Echinococcus-derived miRNAs are present in the biofluids of infected hosts, underscoring their potential for CE diagnosis. Additionally, specific miRNAs from Echinococcus granulosus sensu lato have been shown to influence host–parasite interactions, making them promising therapeutic targets for CE. In conclusion, further investigation into the role of miRNAs in CE could lead to significant breakthroughs in the fight against this neglected disease.
biomarkers; control; Echinococcus granulosus; intermediate hosts; miRNAs; therapeutic targets;
Settore MVET-03/B - Parassitologia e malattie parassitarie degli animali e dell'uomo
ago-2025
Article (author)
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/2434/1181655
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