APOE4 is the strongest genetic risk factor for late-onset Alzheimer's disease (AD). Narayan and Sienski et al. find that APOE4 disrupts early endocytosis, a process by which cells take up external material. By increasing the levels of another AD risk factor, PICALM, the authors are able to reverse these disruptions.
PICALM Rescues Endocytic Defects Caused by the Alzheimer's Disease Risk Factor APOE4 / P. Narayan, G. Sienski, J.M. Bonner, Y.-. Lin, J. Seo, V. Baru, A. Haque, B. Milo, L.A. Akay, A. Graziosi, Y. Freyzon, D. Landgraf, W.R. Hesse, J. Valastyan, M.I. Barrasa, L.-. Tsai, S. Lindquist. - In: CELL REPORTS. - ISSN 2211-1247. - 33:1(2020 Oct 06), pp. 108224.1-108224.14. [10.1016/j.celrep.2020.108224]
PICALM Rescues Endocytic Defects Caused by the Alzheimer's Disease Risk Factor APOE4
A. Graziosi;
2020
Abstract
APOE4 is the strongest genetic risk factor for late-onset Alzheimer's disease (AD). Narayan and Sienski et al. find that APOE4 disrupts early endocytosis, a process by which cells take up external material. By increasing the levels of another AD risk factor, PICALM, the authors are able to reverse these disruptions.
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