In this paper, we develop and numerically study algebraic multigrid (AMG) preconditioners for the cardiac EMI (Extracellular space, cell Membrane, and Intracellular space) model, a recent and biophysically detailed framework for cardiac electrophysiology. The EMI model addresses the limitations of traditional homogenized cardiac models and leverages contemporary computational power to enable high-resolution simulations at the cellular scale. Using a composite Discontinuous Galerkin (DG) discretization, we introduce an AMG-EMI solver for the three dimensional EMI model. Our investigation includes the AMG-EMI scalability performance, both weak and strong, and evaluates its numerical robustness under ischemic conditions, addressing the challenges of heterogeneous media. Numerical tests exploit state-of-the-art pre-exascale supercomputers with hybrid CPU–GPU architectures. The results indicate better scalability performance of the AMG-EMI solver on CPUs compared to GPUs. However, the best solution times achieved using GPUs are up to 40x faster than those obtained on CPUs.

Parallel Algebraic Multigrid Solvers for Composite Discontinuous Galerkin Discretization of the Cardiac EMI Model in Heterogeneous Media / E. Centofanti, N.M.M. Huynh, L.F. Pavarino, S. Scacchi. - In: COMPUTER METHODS IN APPLIED MECHANICS AND ENGINEERING. - ISSN 0045-7825. - 442:(2025 Jul 01), pp. 118001.1-118001.15. [10.1016/j.cma.2025.118001]

Parallel Algebraic Multigrid Solvers for Composite Discontinuous Galerkin Discretization of the Cardiac EMI Model in Heterogeneous Media

N.M.M. Huynh
Secondo
;
L.F. Pavarino
Penultimo
;
S. Scacchi
Ultimo
2025

Abstract

In this paper, we develop and numerically study algebraic multigrid (AMG) preconditioners for the cardiac EMI (Extracellular space, cell Membrane, and Intracellular space) model, a recent and biophysically detailed framework for cardiac electrophysiology. The EMI model addresses the limitations of traditional homogenized cardiac models and leverages contemporary computational power to enable high-resolution simulations at the cellular scale. Using a composite Discontinuous Galerkin (DG) discretization, we introduce an AMG-EMI solver for the three dimensional EMI model. Our investigation includes the AMG-EMI scalability performance, both weak and strong, and evaluates its numerical robustness under ischemic conditions, addressing the challenges of heterogeneous media. Numerical tests exploit state-of-the-art pre-exascale supercomputers with hybrid CPU–GPU architectures. The results indicate better scalability performance of the AMG-EMI solver on CPUs compared to GPUs. However, the best solution times achieved using GPUs are up to 40x faster than those obtained on CPUs.
Algebraic multigrid; Cardiac cell-by-cell models; Composite Discontinuous Galerkin methods; Multilevel solvers; Reaction–diffusion systems;
Settore MATH-05/A - Analisi numerica
   Numerical modeling of cardiac electrophysiology at the cellular scale
   MICROCARD
   European Commission
   Horizon 2020 Framework Programme
   955495

   Numerical modeling of cardiac electrophysiology at the cellular scale
   MICROCARD-2
   European Commission
   Horizon Europe Framework Programme
   101172576

   Computational modeling of the human heart: from efficient numerical solvers to cardiac digital twins
   MINISTERO DELL'UNIVERSITA' E DELLA RICERCA
   202232A8AN_003

   Numerical modeling of cardiac electrophysiology at the cellular scale
   MICROCARD-2
   European Commission
   Horizon Europe Framework Programme
   101172576

   Numerical modeling of cardiac electrophysiology at the cellular scale
   MICROCARD
   European Commission
   Horizon 2020 Framework Programme
   955495
1-lug-2025
Article (author)
File in questo prodotto:
File Dimensione Formato  
j08-cmame-amg-2025.pdf

accesso aperto

Tipologia: Publisher's version/PDF
Licenza: Creative commons
Dimensione 2.38 MB
Formato Adobe PDF
2.38 MB Adobe PDF Visualizza/Apri
Pubblicazioni consigliate

I documenti in IRIS sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.

Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/2434/1171968
Citazioni
  • ???jsp.display-item.citation.pmc??? ND
  • Scopus 0
  • ???jsp.display-item.citation.isi??? 0
  • OpenAlex ND
social impact