Toll-Like Receptor 7 (TLR7) is recognized for its role in immune responses, particularly in detecting viral RNA. However, emerging evidence suggests that TLR7 may also contribute to ocular development. In this study, we assessed the expression pattern of TLR7 in various CD-1 mouse eye compartments during critical developmental stages, from embryonic day 12 to 16, as well as in adult tissues such as the cornea, pigmented epithelium, neural retina and lens. Our findings reveal a regionspecific and time-dependent expression of TLR7, suggesting that it may play a role in the morphogenetic processes that shape the eye during intrauterine development.
Toll-Like Receptor 7 (TLR7) is recognized for its role in immune responses, particularly in detecting viral RNA. However, emerging evidence suggests that TLR7 may also contribute to ocular development. In this study, we assessed the expression pattern of TLR7 in various CD-1 mouse eye compartments during critical developmental stages, from embryonic day 12 to 16, as well as in adult tissues such as the cornea, pigmented epithelium, neural retina and lens. Our findings reveal a region-specific and time-dependent expression of TLR7, suggesting that it may play a role in the morphogenetic processes that shape the eye during intrauterine development.
TLR7 expression patterns in mouse eye development and adult ocular tissues / M. Rasile, M. Sommariva, E. Menegola, F. Di Renzo, M. Anselmi, L. Sfondrini, I. Barajon, F. Arnaboldi. - In: THE INTERNATIONAL JOURNAL OF DEVELOPMENTAL BIOLOGY. - ISSN 0214-6282. - 69:2(2025 Jun), pp. 101-107. [10.1387/ijdb.240229fa]
TLR7 expression patterns in mouse eye development and adult ocular tissues
M. SommarivaCo-primo
;E. MenegolaSecondo
;F. Di Renzo;L. Sfondrini;F. Arnaboldi
Ultimo
2025
Abstract
Toll-Like Receptor 7 (TLR7) is recognized for its role in immune responses, particularly in detecting viral RNA. However, emerging evidence suggests that TLR7 may also contribute to ocular development. In this study, we assessed the expression pattern of TLR7 in various CD-1 mouse eye compartments during critical developmental stages, from embryonic day 12 to 16, as well as in adult tissues such as the cornea, pigmented epithelium, neural retina and lens. Our findings reveal a region-specific and time-dependent expression of TLR7, suggesting that it may play a role in the morphogenetic processes that shape the eye during intrauterine development.
| File | Dimensione | Formato | |
|---|---|---|---|
|
Rasile et al.pdf
accesso aperto
Descrizione: Article
Tipologia:
Publisher's version/PDF
Licenza:
Creative commons
Dimensione
4.66 MB
Formato
Adobe PDF
|
4.66 MB | Adobe PDF | Visualizza/Apri |
Pubblicazioni consigliate
I documenti in IRIS sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.
