Background Enteroviruses (EV) cause yearly outbreaks with severe infections, particularly in young children. This study investigates EV circulation, age, and clinical presentations in Europe from 2018 to 2023.Methods Aggregated data were requested from the European Centre for Disease Prevention and Control National Focal Points for Surveillance and European Non-Polio Enterovirus Network. Data included detection month, specimen type, age group, and clinical presentation for the 10 most commonly reported EV types per year.Results Twenty-eight institutions (16 countries) reported 563 654 EV tests during the study period with 33 265 (5.9%) EV positive. Forty-two types were identified (n = 11 605 cases) with echovirus 30 (E30), coxsackievirus A6 (CVA6), EV-D68, E9, E11, CVB5, E18, CVB4, EV-A71, and E6 most frequently reported. E30 declined after 2018/2019, while CVA6, CVB5, E9, E11, and EV-D68 were prevalent both before and after the coronavirus disease 2019 (COVID-19) pandemic, and CVB4 and E18 were prevalent after the pandemic. A shift in seasons (summer to fall) and specimen positivity (feces to respiratory) was observed. Neurological signs predominated among EV-A71, CVB4, CVB5, E6, E9, E11, E18, and E30 (30%-72%). CVB4, CVB5, E9, E11, and E18 were frequently reported among neonates (18%-32%). CVA6 was frequently associated with hand, foot and mouth disease, and EV-D68 with respiratory infections. Paralysis was reported among 22 infections, associated with 10 nonpolio types.Conclusions This study emphasizes the widespread circulation and severity of EV infections in Europe, as well as the (re)emergence of specific types postpandemic. Our findings highlight the need for continuous EV surveillance to monitor variation in circulation, age, and clinical presentations, including paralysis among nonpolio EV infections.This study provides insight into the changing epidemiological landscape of (re)emerging enteroviruses in Europe in 2018-2023 with severe clinical presentations like neurological infections/paralysis. Echovirus (E)30, coxsackievirus (CV)A6, EV-D68, E9, E11, CVB5, E18, CVB4, EV-A71, and E6 were most frequently reported.
Epidemiological and Clinical Insights into Enterovirus Circulation in Europe, 2018–2023: A Multicenter Retrospective Surveillance Study / S. De Schrijver, E. Vanhulle, A. Ingenbleek, L. Alexakis, C.K. Johannesen, E.K. Broberg, H. Harvala, T.K. Fischer, K.S.M. Benschop, N. Null, J. Albert, N. Allen, L. Andreoletti, S. Atabani, C. Auvray, A. Bart, C. Berengua, N. Berginc, M. Bisseux, H. Boon, A. Bordes-Benitez, A. Bosworth, S. Böttcher, M. Cabrerizo, A. Callegaro, C. Calvo, B. Canning, M. Coste-Burel, K. Couderé, J. Delarbre, S. Diedrich, S. Dudman, R. Dyrdak, J. Exinger, E. Farfour, M.D. Fernandez-Garcia, J. Flipse, V. Foulongne, K.T. Franck, F. Gallais, M. Garcia, I. Georgieva, G. Gonfrier, C. Guillaume, A. Gutierrez-Arroyo, C. Henquell, M. Hooghiemstra, E. Huijskens, A.J. Jääskeläinen, M. Jeannoël, M. Jourdain, E.T. Landaas, K. Keeren, E. Lagarejos, G. Lagathu, S. Larrat, C. Launes, M. Lazrek, C. Lefeuvre, V. Lemée, Q. Lepiller, M. Leruez, D. Leyssene, A.S. L'Honneur, B. Lina, M. Louchet Ducoroy, M.M. Lunar, J. Mansuy, S. Marque Julliet, G. Mcallister, C.P. Mcclure, A. Medina-Claros, G. Megias, S.E. Midgley, A. Mirand, R. Molenkamp, M. Montes, A. Moreno-Docón, C. Munoz-Almagro, J. Murat, J. Murk, A. Navascues-Ortega, M.C. Nieto-Toboso, L. Ninove, M. Oosting, E. Oñate, J. Pacaud, C. Pallier, E. Pariani, L. Pellegrinelli, M. Pérez-Ruiz, S. Pillet, L. Pilorgé, L. Piñeiro, M. Poljak, B. Prochazka, E. Riverain, S. Rogez, M. Salmona, K. Saloum, E. Schaftenaar, C. Schanen, M. Schibler, I. Schuffenecker, K. Stefic, P. Susi, C.M.A. Swanink, C. Tellini, A.L. Toyer, S.C. Uceda Renteria, J. Valencia-Ramos, F.B. Van Loenen, I. Van Loo, V. Venard, J.J. Verweij, K.J. Von Eije, T. Vuorinen, E. Wollants, L. Zanetti. - In: THE JOURNAL OF INFECTIOUS DISEASES. - ISSN 0022-1899. - (2025). [Epub ahead of print] (Intervento presentato al 26. convegno Annual Meeting of the European Society for Clinical Virology tenutosi a Frankfurt nel 2024) [10.1093/infdis/jiaf179].
Epidemiological and Clinical Insights into Enterovirus Circulation in Europe, 2018–2023: A Multicenter Retrospective Surveillance Study
E. Pariani;L. Pellegrinelli;
2025
Abstract
Background Enteroviruses (EV) cause yearly outbreaks with severe infections, particularly in young children. This study investigates EV circulation, age, and clinical presentations in Europe from 2018 to 2023.Methods Aggregated data were requested from the European Centre for Disease Prevention and Control National Focal Points for Surveillance and European Non-Polio Enterovirus Network. Data included detection month, specimen type, age group, and clinical presentation for the 10 most commonly reported EV types per year.Results Twenty-eight institutions (16 countries) reported 563 654 EV tests during the study period with 33 265 (5.9%) EV positive. Forty-two types were identified (n = 11 605 cases) with echovirus 30 (E30), coxsackievirus A6 (CVA6), EV-D68, E9, E11, CVB5, E18, CVB4, EV-A71, and E6 most frequently reported. E30 declined after 2018/2019, while CVA6, CVB5, E9, E11, and EV-D68 were prevalent both before and after the coronavirus disease 2019 (COVID-19) pandemic, and CVB4 and E18 were prevalent after the pandemic. A shift in seasons (summer to fall) and specimen positivity (feces to respiratory) was observed. Neurological signs predominated among EV-A71, CVB4, CVB5, E6, E9, E11, E18, and E30 (30%-72%). CVB4, CVB5, E9, E11, and E18 were frequently reported among neonates (18%-32%). CVA6 was frequently associated with hand, foot and mouth disease, and EV-D68 with respiratory infections. Paralysis was reported among 22 infections, associated with 10 nonpolio types.Conclusions This study emphasizes the widespread circulation and severity of EV infections in Europe, as well as the (re)emergence of specific types postpandemic. Our findings highlight the need for continuous EV surveillance to monitor variation in circulation, age, and clinical presentations, including paralysis among nonpolio EV infections.This study provides insight into the changing epidemiological landscape of (re)emerging enteroviruses in Europe in 2018-2023 with severe clinical presentations like neurological infections/paralysis. Echovirus (E)30, coxsackievirus (CV)A6, EV-D68, E9, E11, CVB5, E18, CVB4, EV-A71, and E6 were most frequently reported.
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