Are sleep disturbances a risk factor for suicidal behavior in the first episode of psychosis? Evidence from a systematic review

Sleep disturbances are common in individuals with first-episode psychosis (FEP) and have been identified as potential contributors to an increased risk of suicidal behavior. This systematic review aims to synthesize the existing evidence on the association between sleep disturbances and suicidal behavior in individuals experiencing FEP, a critical period for early intervention. In accordance with the guidelines established by PRISMA, this systematic review was duly registered in PROSPERO (CRD42024598203) prior to its initiation. A comprehensive search was conducted across databases including PubMed, Web of Science, EMBASE, and PsycINFO, encompassing studies from their inception through February 2025. The review specifically included observational studies that investigated the association between sleep disturbances and suicidal behaviors, which include suicidal ideation, attempts, or completed suicides, among individuals with FEP. The inclusion criteria required that all studies featured adult participants aged 18 years and older, employed validated measures for both sleep disturbances and suicidality, and concentrated on populations with FEP. Reviews, case reports, and studies not published in English were systematically excluded. The selection of studies, extraction of data, and assessment of quality were conducted independently by two reviewers. Seven studies met the inclusion criteria, with sample sizes ranging from 118 to 688 participants. The findings indicate that sleep disturbances, especially insomnia, are significantly linked to an increased risk of suicidal ideation and behavior in individuals with FEP. The strength of these associations varied among the studies, with some reporting moderate to strong effect sizes. However, there was noted methodological heterogeneity, including variations in sleep assessment tools. This systematic review highlights sleep disturbances as a key modifiable risk factor for suicidal behavior in individuals with FEP. Future research should prioritize longitudinal designs and standardized sleep assessments to better characterize this relationship and guide targeted interventions.