Cardiovascular arterial thrombosis poses a major health burden, despite intensive antiplatelet therapy, and platelet hyper-reactivity drives thrombus formation, yet its molecular mechanisms remain unknown. A study now shows that gut microbiota–derived deoxycholic acid modulates platelet activity and thrombosis risk in coronary artery disease.
A perspective on thrombogenesis through gut microbiota-derived bile acids and platelet activation / C. Menni, A.M. Valdes. - In: NATURE CARDIOVASCULAR RESEARCH. - ISSN 2731-0590. - 4:5(2025), pp. 505-507. [10.1038/s44161-025-00634-0]
A perspective on thrombogenesis through gut microbiota-derived bile acids and platelet activation
C. Menni
Primo
;
2025
Abstract
Cardiovascular arterial thrombosis poses a major health burden, despite intensive antiplatelet therapy, and platelet hyper-reactivity drives thrombus formation, yet its molecular mechanisms remain unknown. A study now shows that gut microbiota–derived deoxycholic acid modulates platelet activity and thrombosis risk in coronary artery disease.
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