Exploiting the amide-triazole bioisosterism, in this work we report the synthesis of the first generation of epothilones lacking the macrolide or azalide structure, with the ester or amide linkage replaced by a triazole unit.
Synthesis of the first Epothilone Analogue Utilizing Amide‒Triazole Bioisosterism / S. Borsoi. ((Intervento presentato al convegno ISPROCHEM 2024 International School of Process Chemistry - Advanced Edition : 26-29 maggio tenutosi a Gargnano nel 2024.
Synthesis of the first Epothilone Analogue Utilizing Amide‒Triazole Bioisosterism
S. Borsoi
2024
Abstract
Exploiting the amide-triazole bioisosterism, in this work we report the synthesis of the first generation of epothilones lacking the macrolide or azalide structure, with the ester or amide linkage replaced by a triazole unit.
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