first_pageDownload PDFsettingsOrder Article Reprints Open AccessArticle Formulation Study of a Poly(Amino Methacrylate) Film-Forming Solution for Transdermal Administration by Chiara G. M. Gennari,Antonella CasiraghiORCID,Francesca Selmin *ORCID andFrancesco CilurzoORCID Department of Pharmaceutical Sciences, Università degli Studi di Milano, via G: Colombo, 71, 20133 Milano, Italy * Author to whom correspondence should be addressed. Pharmaceutics 2025, 17(1), 88; https://doi.org/10.3390/pharmaceutics17010088 Submission received: 20 December 2024 / Revised: 7 January 2025 / Accepted: 9 January 2025 / Published: 11 January 2025 (This article belongs to the Special Issue Emerging Trends in Skin Delivery Systems) Downloadkeyboard_arrow_down Browse Figures Versions Notes Abstract Background/Objectives: The objective of this paper is to design a novel film-forming system (FFS) based on Eudragit® E PO (EuE) polymeric solutions, differing in volatile solvents (i.e., isopropanol and ethanol) and plasticizers (i.e., tributylcitrate, glycerine, triacetin and PEG 400). Methods: The physicochemical and mechanical properties of the FFS and dried films were evaluated in terms of formation time, stickiness, Tg, tensile strength, break elongation and Young’s modulus. The in vitro skin permeation studies were conducted on formulations containing caffeine and testosterone. Results: The FFS, consisting of EuE and PEG400 in isopropyl alcohol and ethanol (80:20, v/v), exhibited rapid film formation within about 5 min and the dried film allowed a high skin permeability compared to other formulations due to the ability to increase the thermodynamic activity of both drugs. When triiodothyronine (T3) was loaded as a model of a very low soluble drug, tocopherol polyethylene glycol succinate (TPGS) was added as a co-solvent and it allowed for the improvement of T3 retention in the skin. Conclusions: Among the formulative variables, the nature and the amount of plasticizer represent the most critical variables to obtain an EuE-based film with satisfying physical and biopharmaceutical properties.

Formulation Study of a Poly(Amino Methacrylate) Film-Forming Solution for Transdermal Administration / C. Gennari, A. Casiraghi, F. Selmin, F. Cilurzo. - In: PHARMACEUTICS. - ISSN 1999-4923. - 17:1(2025 Jan 11), pp. 88.1-88.12. [10.3390/pharmaceutics17010088]

Formulation Study of a Poly(Amino Methacrylate) Film-Forming Solution for Transdermal Administration

C. Gennari
Primo
;
A. Casiraghi
Secondo
;
F. Selmin
Penultimo
;
F. Cilurzo
Ultimo
2025

Abstract

first_pageDownload PDFsettingsOrder Article Reprints Open AccessArticle Formulation Study of a Poly(Amino Methacrylate) Film-Forming Solution for Transdermal Administration by Chiara G. M. Gennari,Antonella CasiraghiORCID,Francesca Selmin *ORCID andFrancesco CilurzoORCID Department of Pharmaceutical Sciences, Università degli Studi di Milano, via G: Colombo, 71, 20133 Milano, Italy * Author to whom correspondence should be addressed. Pharmaceutics 2025, 17(1), 88; https://doi.org/10.3390/pharmaceutics17010088 Submission received: 20 December 2024 / Revised: 7 January 2025 / Accepted: 9 January 2025 / Published: 11 January 2025 (This article belongs to the Special Issue Emerging Trends in Skin Delivery Systems) Downloadkeyboard_arrow_down Browse Figures Versions Notes Abstract Background/Objectives: The objective of this paper is to design a novel film-forming system (FFS) based on Eudragit® E PO (EuE) polymeric solutions, differing in volatile solvents (i.e., isopropanol and ethanol) and plasticizers (i.e., tributylcitrate, glycerine, triacetin and PEG 400). Methods: The physicochemical and mechanical properties of the FFS and dried films were evaluated in terms of formation time, stickiness, Tg, tensile strength, break elongation and Young’s modulus. The in vitro skin permeation studies were conducted on formulations containing caffeine and testosterone. Results: The FFS, consisting of EuE and PEG400 in isopropyl alcohol and ethanol (80:20, v/v), exhibited rapid film formation within about 5 min and the dried film allowed a high skin permeability compared to other formulations due to the ability to increase the thermodynamic activity of both drugs. When triiodothyronine (T3) was loaded as a model of a very low soluble drug, tocopherol polyethylene glycol succinate (TPGS) was added as a co-solvent and it allowed for the improvement of T3 retention in the skin. Conclusions: Among the formulative variables, the nature and the amount of plasticizer represent the most critical variables to obtain an EuE-based film with satisfying physical and biopharmaceutical properties.
drug delivery system; Eudragit® E; film-forming solution; plasticizer; skin permeability; supersaturation; triiodothyronine; transdermal drug delivery;
Settore CHEM-08/A - Tecnologia, socioeconomia e normativa dei medicinali e dei prodotti per il benessere e per la salute
11-gen-2025
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/2434/1134095
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