The continuous remodeling of progressing tumors demands non-physiologic production of extracellular matrix (ECM) proteins. Among them, osteopontin (OPN) has been largely involved in tumor progression and metastasis. We have recently discovered a new mechanism for OPN in the metastatic spread of mammary carcinoma providing local immunosuppression at the seeding site.
The ins and outs of osteopontin / C. Chiodoni, S. Sangaletti, C. Tripodo, M. Colombo. - In: ONCOIMMUNOLOGY. - ISSN 2162-4011. - 4:3(2015), pp. e978711.1-e978711.2. [10.4161/2162402X.2014.978711]
The ins and outs of osteopontin
C. Tripodo;
2015
Abstract
The continuous remodeling of progressing tumors demands non-physiologic production of extracellular matrix (ECM) proteins. Among them, osteopontin (OPN) has been largely involved in tumor progression and metastasis. We have recently discovered a new mechanism for OPN in the metastatic spread of mammary carcinoma providing local immunosuppression at the seeding site.
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