Cardiovascular diseases are the leading cause of death worldwide, claiming millions of lives every year. Cardiac tissue engineering has emerged as a versatile option for repairing cardiac tissue and helping its regeneration. The use of nanomaterials, particularly nanofiber-based scaffolds combined with biomolecular cues like peptides, has significantly improved the compatibility and efficacy of the scaffolds for cardiac tissue regeneration. By utilising the self-assembly properties of peptides to create nanofiber scaffolds, we can achieve stability that closely mimics the natural components of cardiac tissue, making them perfect for cardiac tissue regeneration. In this review, we highlighted the dynamic process of self-assembly into nanofibers and the use of various self-assembled nanofibers for cardiovascular tissue regeneration, focusing on their roles in antithrombotic, angiogenic, differentiation, proliferation, and anti-atherosclerotic interventions.

Self-assembled peptide-based nanofibers for cardiovascular tissue regeneration / D. Shenoy, S. Chivukula, N. Erdogan, E. Chiesa, S. Pellegrino, M. Reches, I. Genta. - In: JOURNAL OF MATERIALS CHEMISTRY. B. - ISSN 2050-750X. - (2024), pp. 1-14. [Epub ahead of print] [10.1039/d4tb01235f]

Self-assembled peptide-based nanofibers for cardiovascular tissue regeneration

D. Shenoy
Co-primo
;
S. Pellegrino
;
2024

Abstract

Cardiovascular diseases are the leading cause of death worldwide, claiming millions of lives every year. Cardiac tissue engineering has emerged as a versatile option for repairing cardiac tissue and helping its regeneration. The use of nanomaterials, particularly nanofiber-based scaffolds combined with biomolecular cues like peptides, has significantly improved the compatibility and efficacy of the scaffolds for cardiac tissue regeneration. By utilising the self-assembly properties of peptides to create nanofiber scaffolds, we can achieve stability that closely mimics the natural components of cardiac tissue, making them perfect for cardiac tissue regeneration. In this review, we highlighted the dynamic process of self-assembly into nanofibers and the use of various self-assembled nanofibers for cardiovascular tissue regeneration, focusing on their roles in antithrombotic, angiogenic, differentiation, proliferation, and anti-atherosclerotic interventions.
Settore CHEM-05/A - Chimica organica
   Functional Nano-Scaffolds for Regenerative Medicine
   NANOREMEDI
   European Commission
   Horizon Europe Framework Programme
   101072645
2024
10-dic-2024
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/2434/1123642
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