Tobacco smoke has numerous adverse effects on both human and animal health, including impaired reproductive function. Recent research has explored environmental exposure in dogs, investigating various biological matrices. However, no data are currently available on the presence of cotinine, a nicotine metabolite, in the canine ejaculate. This study aimed to evaluate the detectability of cotinine in the semen of dogs living with smoking owners. Additionally, seminal cotinine concen- trations were correlated with those in serum and hair. To further examine the potential impact of smoking on canine fertility, the relationships between seminal cotinine, total sperm concentration, and antioxidant activity in plasma and semen were analyzed in exposed and non-exposed dogs. This study is the first to demonstrate the presence of cotinine in canine ejaculate and its correlation with blood and hair concentrations. While the potential toxic effect of cotinine on seminal parameters and male fertility in dogs requires further investigation, it is crucial to raise awareness among pet owners about the risks associated with domestic smoking for their animals.

First Evidence of Cotinine in Canine Semen Reveals Tobacco Smoke Exposure / D. Groppetti, G. Pizzi, E. Giussani, A. Pecile, S.M. Mazzola, V. Bronzo, E. Fusi. - In: VETERINARY SCIENCES. - ISSN 2306-7381. - 11:12(2024 Nov), pp. 598.1-598.8. [10.3390/vetsci11120598]

First Evidence of Cotinine in Canine Semen Reveals Tobacco Smoke Exposure

D. Groppetti
Primo
Conceptualization
;
G. Pizzi
Secondo
Conceptualization
;
E. Giussani
Investigation
;
A. Pecile
Investigation
;
S.M. Mazzola
Methodology
;
V. Bronzo
Penultimo
Formal Analysis
;
E. Fusi
Ultimo
Methodology
2024

Abstract

Tobacco smoke has numerous adverse effects on both human and animal health, including impaired reproductive function. Recent research has explored environmental exposure in dogs, investigating various biological matrices. However, no data are currently available on the presence of cotinine, a nicotine metabolite, in the canine ejaculate. This study aimed to evaluate the detectability of cotinine in the semen of dogs living with smoking owners. Additionally, seminal cotinine concen- trations were correlated with those in serum and hair. To further examine the potential impact of smoking on canine fertility, the relationships between seminal cotinine, total sperm concentration, and antioxidant activity in plasma and semen were analyzed in exposed and non-exposed dogs. This study is the first to demonstrate the presence of cotinine in canine ejaculate and its correlation with blood and hair concentrations. While the potential toxic effect of cotinine on seminal parameters and male fertility in dogs requires further investigation, it is crucial to raise awareness among pet owners about the risks associated with domestic smoking for their animals.
cigarette; dog; oxidative stress; smoking; sperm concentration
Settore MVET-05/B - Clinica ostetrica, ginecologica, andrologica e neonatologia veterinaria
   Piano di Sostegno alla Ricerca 2015-2017 - Linea 2 "Dotazione annuale per attività istituzionali" (anno 2019)
   UNIVERSITA' DEGLI STUDI DI MILANO
nov-2024
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/2434/1121831
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