This report compares a traditional full-dose ifosfamide administration modality (24-hr hyperhydration and mesna infusion) with a simplified 9-hr hyperhydration and mesna infusion for use in outpatients. Acute ifosfamide toxicity was the same, suggesting that ifosfamide could be safely administered to outpatients, reducing the currently-recommended prolonged hyperhydration and mesna uroprotection, thus resulting in shorter hospital stays and consequently lower costs.
Full-dose ifosfamide can be safely administered to outpatients / C. Meazza, G. Bisogno, M. Casanova, I. Zanetti, M. Carli, A. Ferrari. - In: PEDIATRIC BLOOD & CANCER. - ISSN 1545-5009. - 50:2(2008), pp. 375-378.
Full-dose ifosfamide can be safely administered to outpatients.
A. Ferrari
2008
Abstract
This report compares a traditional full-dose ifosfamide administration modality (24-hr hyperhydration and mesna infusion) with a simplified 9-hr hyperhydration and mesna infusion for use in outpatients. Acute ifosfamide toxicity was the same, suggesting that ifosfamide could be safely administered to outpatients, reducing the currently-recommended prolonged hyperhydration and mesna uroprotection, thus resulting in shorter hospital stays and consequently lower costs.
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