A survey on the role played by ceramide within the sphingolmyelin pathway is here reported, taking into account its importance as an intracellular effector molecule in apoptosis. Recently, several analogs of ceramide, able to pass the cell membrane and then to induce apoptosis, have been developed as a new potential approach in anticancer therapy. © 2003 Éditions scientifiques et médicales Elsevier SAS. All rights reserved.
Ceramide analogues in apoptosis: a new strategy for anticancer drug development / M. Macchia, S. Bertini, S. Fogli, E. Giovannetti, F. Minutolo, S. Rapposelli, R. Danesi. - In: IL FARMACO. - ISSN 0014-827X. - 58:3(2003 Mar), pp. 205-211. [10.1016/S0014-827X(03)00015-6]
Ceramide analogues in apoptosis: a new strategy for anticancer drug development
R. Danesi
2003
Abstract
A survey on the role played by ceramide within the sphingolmyelin pathway is here reported, taking into account its importance as an intracellular effector molecule in apoptosis. Recently, several analogs of ceramide, able to pass the cell membrane and then to induce apoptosis, have been developed as a new potential approach in anticancer therapy. © 2003 Éditions scientifiques et médicales Elsevier SAS. All rights reserved.
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