Five cases of non-small cell lung cancer, associated with germline transmission of epidermal growth factor receptor (EGFR)-T790M mutation, have been reported1; these patients had family histories of lung cancer. The activity of gefitinib was tested in only two patients, who were both refractory to this drug.2 Herein, we describe a family of European descent in which two family members had non-small cell lung cancer associated with germline transmission of T790M mutation and who were treated with gefitinib.
Inherited germline T790M mutation and somatic epidermal growth factor receptor mutations in non-small cell lung cancer patients / T. C., G. E., V. E., L. Boldrini, G.R. M. I., B. I., I. R., R. Danesi, C. F., P. G. J., G. Fontanini. - In: JOURNAL OF THORACIC ONCOLOGY. - ISSN 1556-0864. - 6:2(2011), pp. 395-396. [10.1097/JTO.0b013e3182059a6f]
Inherited germline T790M mutation and somatic epidermal growth factor receptor mutations in non-small cell lung cancer patients
R. Danesi;G. Fontanini
2011
Abstract
Five cases of non-small cell lung cancer, associated with germline transmission of epidermal growth factor receptor (EGFR)-T790M mutation, have been reported1; these patients had family histories of lung cancer. The activity of gefitinib was tested in only two patients, who were both refractory to this drug.2 Herein, we describe a family of European descent in which two family members had non-small cell lung cancer associated with germline transmission of T790M mutation and who were treated with gefitinib.
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