Brain metastases pose a significant challenge in radiotherapy. Stereotactic radiosurgery (SRS) is an effective local therapeutic approach used. However, concern regarding radiation necrosis emerges when doses to normal brain tissue exceeds 12 Gy. Proton therapy (PT) presents a promising alternative, but there is a lack of comprehensive dosimetric data comparing proton with photon treatments from randomized trials. We address this gap by conducting a dosimetric comparison between proton and photon plans from patients enrolled in a prospective randomized trial (NCT02355613), evaluating doses to organs at risk and target coverage to provide clinical decision guidance in identifying PT benefits.
Optimizing Treatment Strategies for Brain Metastases: A Dosimetric Comparison of Proton and Photon radiosurgery / M. Pelizzoli. - (2024 Nov 14).
Optimizing Treatment Strategies for Brain Metastases: A Dosimetric Comparison of Proton and Photon radiosurgery
M. Pelizzoli
2024
Abstract
Brain metastases pose a significant challenge in radiotherapy. Stereotactic radiosurgery (SRS) is an effective local therapeutic approach used. However, concern regarding radiation necrosis emerges when doses to normal brain tissue exceeds 12 Gy. Proton therapy (PT) presents a promising alternative, but there is a lack of comprehensive dosimetric data comparing proton with photon treatments from randomized trials. We address this gap by conducting a dosimetric comparison between proton and photon plans from patients enrolled in a prospective randomized trial (NCT02355613), evaluating doses to organs at risk and target coverage to provide clinical decision guidance in identifying PT benefits.
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