The communication between tumor cells and their neighbors is important for disease progression. Here, Bertolini et al. show that hypoxic breast cancer cells release small extracellular vesicles that introduce multiple malignant changes in the normal mammary epithelium via reprogramming of mitochondrial functions. This pathway may promote local breast cancer recurrences.
Small Extracellular Vesicle Regulation of Mitochondrial Dynamics Reprograms a Hypoxic Tumor Microenvironment / I. Bertolini, J.C. Ghosh, A.V. Kossenkov, S. Mulugu, S.R. Krishn, V. Vaira, J. Qin, E.F. Plow, L.R. Languino, D.C. Altieri. - In: DEVELOPMENTAL CELL. - ISSN 1534-5807. - 55:2(2020), pp. 163-177. [10.1016/j.devcel.2020.07.014]
Small Extracellular Vesicle Regulation of Mitochondrial Dynamics Reprograms a Hypoxic Tumor Microenvironment
I. Bertolini;V. Vaira;
2020
Abstract
The communication between tumor cells and their neighbors is important for disease progression. Here, Bertolini et al. show that hypoxic breast cancer cells release small extracellular vesicles that introduce multiple malignant changes in the normal mammary epithelium via reprogramming of mitochondrial functions. This pathway may promote local breast cancer recurrences.
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