Electroorganic synthesis has become an exciting tool for the asymmetric conversion of pro-chiral compounds. Herein, we introduced a wireless methodology based on bipolar electrochemistry in synergy with the enantioselective capabilities of inherently chiral oligomers to induce an umpolung chirality transfer. This was exemplified by the electro-conversion of a racemic mixture of lansoprazole to an enantio-enriched solution of a single antipode.
Wireless asymmetric umpolung electrosynthesis / S. Grecchi, B. Bonczak, F. Malacarne, G. Salinas, R. Cirilli, S. Arnaboldi. - In: CHEMICAL COMMUNICATIONS. - ISSN 1364-548X. - 60:74(2024), pp. 10120-10123. [10.1039/d4cc02406k]
Wireless asymmetric umpolung electrosynthesis.
S. GrecchiCo-primo
;B. BonczakCo-primo
;F. Malacarne;S. Arnaboldi
Ultimo
2024
Abstract
Electroorganic synthesis has become an exciting tool for the asymmetric conversion of pro-chiral compounds. Herein, we introduced a wireless methodology based on bipolar electrochemistry in synergy with the enantioselective capabilities of inherently chiral oligomers to induce an umpolung chirality transfer. This was exemplified by the electro-conversion of a racemic mixture of lansoprazole to an enantio-enriched solution of a single antipode.
| File | Dimensione | Formato | |
|---|---|---|---|
|
33_ChemComm Lans.pdf
accesso aperto
Descrizione: Article
Tipologia:
Publisher's version/PDF
Dimensione
676.54 kB
Formato
Adobe PDF
|
676.54 kB | Adobe PDF | Visualizza/Apri |
Pubblicazioni consigliate
I documenti in IRIS sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.
