The intricate nature of carbohydrate structures has prompted the scientific community to seek efficient protocols for their manipulation. Lengthy synthetic pathways, often necessary to achieve complex sugar structures, pose challenges not only in terms of time and cost but also regarding environmental sustainability. Consequently, domino transformations serve as valuable tools in streamlining drug discovery processes. Sequential procedures involving fewer steps and minimal isolation/purification steps are particularly appealing to organic chemists in the field of carbohydrate chemistry. This review highlights several examples of domino transformations applied to carbohydrates, aiming to summarize their chemical potential in delivering sugar-based compounds with significant applications in the generation of new chemical scaffolds for drug discovery and chemical biology.Domino transformations play a crucial role as chemical tools in drug discovery processes. This review showcases various instances of domino transformations applied to carbohydrates, with the goal of summarizing their chemical potential in producing sugar-derived compounds. These compounds have significant applications in generating new chemical scaffolds for drug discovery and chemical biology.
Unleashing the power of domino reactions on carbohydrates: state of the art / G. Antonini, L. Petrosilli, I. Giussani, M.G. Ciulla, S. Mazzotta, G. D'Orazio. - In: EUROPEAN JOURNAL OF ORGANIC CHEMISTRY. - ISSN 1434-193X. - (2024 Oct 02). [Epub ahead of print] [10.1002/ejoc.202400511]
Unleashing the power of domino reactions on carbohydrates: state of the art
G. AntoniniPrimo
;L. Petrosilli;M.G. Ciulla;S. Mazzotta
Penultimo
;G. D'Orazio
Ultimo
2024
Abstract
The intricate nature of carbohydrate structures has prompted the scientific community to seek efficient protocols for their manipulation. Lengthy synthetic pathways, often necessary to achieve complex sugar structures, pose challenges not only in terms of time and cost but also regarding environmental sustainability. Consequently, domino transformations serve as valuable tools in streamlining drug discovery processes. Sequential procedures involving fewer steps and minimal isolation/purification steps are particularly appealing to organic chemists in the field of carbohydrate chemistry. This review highlights several examples of domino transformations applied to carbohydrates, aiming to summarize their chemical potential in delivering sugar-based compounds with significant applications in the generation of new chemical scaffolds for drug discovery and chemical biology.Domino transformations play a crucial role as chemical tools in drug discovery processes. This review showcases various instances of domino transformations applied to carbohydrates, with the goal of summarizing their chemical potential in producing sugar-derived compounds. These compounds have significant applications in generating new chemical scaffolds for drug discovery and chemical biology.File | Dimensione | Formato | |
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