Genetic analysis of over 1 million people identifies 535 new loci associated with blood pressure traits

Evangelou, E.; Warren, H.; Mosen-Ansorena, D.; Mifsu, B.; Pazoki, R.; Gao, H.; Ntritsos, G.; Dimou, N.; Cabrer, C.; Karaman, I.; Fl, N.; Evangelou, M.; Witkowska, K.; Tzanis, E.; Hellwege, J.; Giri, A.; Drv, E.; Sun, Y.; Cho, K.; Gaziano, J.; Pwf, W.; Tsao, P.; Kovesdy, C.; Esko, T.; Magi, R.; Milani, L.; Almgren, P.; Boutin, T.; Debette, S.; Ding, J.; Giulianini, F.; Holliday, E.; Jackson, A.; Li-Gao, R.; Lin, W.; Luan, J.; Mangino, M.; Oldmeadow, C.; Prins, B.; Qian, Y.; Sargurupremraj, M.; Shah, N.; Surendran, P.; Theriault, S.; Verweij, N.; Willems, S.; Zhao, J.; Amouyel, P.; Connell, J.; de Mutsert, R.; Asf, D.; Farrall, M.; Menni, C.; Morris, A.; Noordam, R.; Pare, G.; Poulter, N.; Shields, D.; Stanton, A.; Thom, S.; Abecasis, G.; Amin, N.; Arking, D.; Ayers, K.; Barbieri, C.; Batini, C.; Bis, J.; Blake, T.; Bochud, M.; Boehnke, M.; Boerwinkle, E.; Boomsma, D.; Bottinger, E.; Braund, P.; Brumat, M.; Campbell, A.; Campbell, H.; Chakravarti, A.; Chambers, J.; Chauhan, G.; Ciullo, M.; Cocca, M.; Collins, F.; Cordell, H.; Davies, G.; de Borst MH,; de Geus EJ,; Deary, I.; Deelen, J.; Del Greco MF,; Demirkale, C.; Dorr, M.; Ehret, G.; Elosua, R.; Enroth, S.; Erzurumluoglu, A.; Ferreira, T.; Franberg, M.; Franco, O.; Gandin, I.; Gasparini, P.; Giedraitis, V.; Gieger, C.; Girotto, G.; Goel, A.; Gow, A.; Gudnason, V.; Guo, X.; Gyllensten, U.; Hamsten, A.; Harris, T.; Harris, S.; Hartman, C.; Havulinna, A.; Hicks, A.; Hofer, E.; Hofman, A.; Hottenga, J.; Huffman, J.; Hwang, S.; Ingelsson, E.; James, A.; Jansen, R.; Jarvelin, M.; Joehanes, R.; Johansson, A.; Johnson, A.; Joshi, P.; Jousilahti, P.; Jukema, J.; Jula, A.; Kahonen, M.; Kathiresan, S.; Keavney, B.; Khaw, K.; Knekt, P.; Knight, J.; Kolcic, I.; Kooner, J.; Koskinen, S.; Kristiansson, K.; Kutalik, Z.; Laan, M.; Larson, M.; Launer, L.; Lehne, B.; Lehtimaki, T.; Dcm, L.; Lin, L.; Lind, L.; Lindgren, C.; Liu, Y.; Rjf, L.; Lopez, L.; Yc, L.; Lyytikainen, L.; Mahajan, A.; Mamasoula, C.; Marrugat, J.; Marten, J.; Milaneschi, Y.; Morgan, A.; Morris, A.; Morrison, A.; Munson, P.; Nalls, M.; Nandakumar, P.; Nelson, C.; Niiranen, T.; Nolte, I.; Nutile, T.; Oldehinkel, A.; Oostra, B.; O'Reilly, P.; Org, E.; Padmanabhan, S.; Palmas, W.; Palotie, A.; Pattie, A.; Bwjh, P.; Perola, M.; Peters, A.; Polasek, O.; Pramstaller, P.; Nguyen, Q.; Raitakari, O.; Ren, M.; Rettig, R.; Rice, K.; Ridker, P.; Ried, J.; Riese, H.; Ripatti, S.; Robino, A.; Rose, L.; Rotter, J.; Rudan, I.; Ruggiero, D.; Saba, Y.; Sala, C.; Salomaa, V.; Samani, N.; Sarin, A.; Schmidt, R.; Schmidt, H.; Shrine, N.; Siscovick, D.; Smith, A.; Snieder, H.; Sober, S.; Sorice, R.; Starr, J.; Stott, D.; Strachan, D.; Strawbridge, R.; Sundstrom, J.; Swertz, M.; Taylor, K.; Teumer, A.; Tobin, M.; Tomaszewski, M.; Toniolo, D.; Traglia, M.; Trompet, S.; Tuomilehto, J.; Tzourio, C.; Uitterlinden, A.; Vaez, A.; van der Most PJ,; van Duijn CM,; Vergnaud, A.; Verwoert, G.; Vitart, V.; Volker, U.; Vollenweider, P.; Vuckovic, D.; Watkins, H.; Wild, S.; Willemsen, G.; Wilson, J.; Wright, A.; Yao, J.; Zemunik, T.; Zhang, W.; Attia, J.; Butterworth, A.; Chasman, D.; Conen, D.; Cucca, F.; Danesh, J.; Hayward, C.; Jmm, H.; Laakso, M.; Lakatta, E.; Langenberg, C.; Melander, O.; Mook-Kanamori, D.; Cna, P.; Risch, L.; Scott, R.; Scott, R.; Sever, P.; Spector, T.; van der Harst, P.; Wareham, N.; Zeggini, E.; Levy, D.; Munroe, P.; Newton-Cheh, C.; Brown, M.; Metspalu, A.; Hung, A.; O'Donnell, C.; Edwards, T.; Psaty, B.; Tzoulaki, I.; Barnes, M.; Wain, L.; Elliott, P.; Caulfield, M.

doi:10.1038/s41588-018-0205-x

High blood pressure is a highly heritable and modifiable risk factor for cardiovascular disease. We report the largest genetic association study of blood pressure traits (systolic, diastolic and pulse pressure) to date in over 1 million people of European ancestry. We identify 535 novel blood pressure loci that not only offer new biological insights into blood pressure regulation but also highlight shared genetic architecture between blood pressure and lifestyle exposures. Our findings identify new biological pathways for blood pressure regulation with potential for improved cardiovascular disease prevention in the future.

Genetic analysis of over 1 million people identifies 535 new loci associated with blood pressure traits / E. Evangelou, H. Warren, D. Mosen-Ansorena, B. Mifsu, R. Pazoki, H. Gao, G. Ntritsos, N. Dimou, C. Cabrer, I. Karaman, F. Ng, M. Evangelou, K. Witkowska, E. Tzanis, J. Hellwege, A. Giri, D. Edwards, Y. Sun, K. Cho, J. Gaziano, P. Wilson, P. Tsao, C. Kovesdy, T. Esko, R. Magi, L. Milani, P. Almgren, T. Boutin, S. Debette, J. Ding, F. Giulianini, E. Holliday, A. Jackson, R. Li-Gao, W. Lin, J. Luan, M. Mangino, C. Oldmeadow, B. Prins, Y. Qian, M. Sargurupremraj, N. Shah, P. Surendran, S. Theriault, N. Verweij, S. Willems, J. Zhao, P. Amouyel, J. Connell, R. de Mutsert, A. Doney, M. Farrall, C. Menni, A. Morris, R. Noordam, G. Pare, N. Poulter, D. Shields, A. Stanton, S. Thom, G. Abecasis, N. Amin, D. Arking, K. Ayers, C. Barbieri, C. Batini, J. Bis, T. Blake, M. Bochud, M. Boehnke, E. Boerwinkle, D. Boomsma, E. Bottinger, P. Braund, M. Brumat, A. Campbell, H. Campbell, A. Chakravarti, J. Chambers, G. Chauhan, M. Ciullo, M. Cocca, F. Collins, H. Cordell, G. Davies, M. de Borst, E. de Geus, I. Deary, J. Deelen, M. Del Greco, C. Demirkale, M. Dorr, G. Ehret, R. Elosua, S. Enroth, A. Erzurumluoglu, T. Ferreira, M. Franberg, O. Franco, I. Gandin, P. Gasparini, V. Giedraitis, C. Gieger, G. Girotto, A. Goel, A. Gow, V. Gudnason, X. Guo, U. Gyllensten, A. Hamsten, T. Harris, S. Harris, C. Hartman, A. Havulinna, A. Hicks, E. Hofer, A. Hofman, J. Hottenga, J. Huffman, S. Hwang, E. Ingelsson, A. James, R. Jansen, M. Jarvelin, R. Joehanes, A. Johansson, A. Johnson, P. Joshi, P. Jousilahti, J. Jukema, A. Jula, M. Kahonen, S. Kathiresan, B. Keavney, K. Khaw, P. Knekt, J. Knight, I. Kolcic, J. Kooner, S. Koskinen, K. Kristiansson, Z. Kutalik, M. Laan, M. Larson, L. Launer, B. Lehne, T. Lehtimaki, D. Liewald, L. Lin, L. Lind, C. Lindgren, Y. Liu, R. Loos, L. Lopez, Y. Lu, L. Lyytikainen, A. Mahajan, C. Mamasoula, J. Marrugat, J. Marten, Y. Milaneschi, A. Morgan, A. Morris, A. Morrison, P. Munson, M. Nalls, P. Nandakumar, C. Nelson, T. Niiranen, I. Nolte, T. Nutile, A. Oldehinkel, B. Oostra, P. O'Reilly, E. Org, S. Padmanabhan, W. Palmas, A. Palotie, A. Pattie, B. Penninx, M. Perola, A. Peters, O. Polasek, P. Pramstaller, Q. Nguyen, O. Raitakari, M. Ren, R. Rettig, K. Rice, P. Ridker, J. Ried, H. Riese, S. Ripatti, A. Robino, L. Rose, J. Rotter, I. Rudan, D. Ruggiero, Y. Saba, C. Sala, V. Salomaa, N. Samani, A. Sarin, R. Schmidt, H. Schmidt, N. Shrine, D. Siscovick, A. Smith, H. Snieder, S. Sober, R. Sorice, J. Starr, D. Stott, D. Strachan, R. Strawbridge, J. Sundstrom, M. Swertz, K. Taylor, A. Teumer, M. Tobin, M. Tomaszewski, D. Toniolo, M. Traglia, S. Trompet, J. Tuomilehto, C. Tzourio, A. Uitterlinden, A. Vaez, P. van der Most, C. van Duijn, A. Vergnaud, G. Verwoert, V. Vitart, U. Volker, P. Vollenweider, D. Vuckovic, H. Watkins, S. Wild, G. Willemsen, J. Wilson, A. Wright, J. Yao, T. Zemunik, W. Zhang, J. Attia, A. Butterworth, D. Chasman, D. Conen, F. Cucca, J. Danesh, C. Hayward, J. Howson, M. Laakso, E. Lakatta, C. Langenberg, O. Melander, D. Mook-Kanamori, C. Palmer, L. Risch, R. Scott, R. Scott, P. Sever, T. Spector, P. van der Harst, N. Wareham, E. Zeggini, D. Levy, P. Munroe, C. Newton-Cheh, M. Brown, A. Metspalu, A. Hung, C. O'Donnell, T. Edwards, B. Psaty, I. Tzoulaki, M. Barnes, L. Wain, P. Elliott, M. Caulfield. - In: NATURE GENETICS. - ISSN 1061-4036. - 50:10(2018), pp. 1412-1425. [10.1038/s41588-018-0205-x]

Genetic analysis of over 1 million people identifies 535 new loci associated with blood pressure traits

Evangelou E;Warren HR;Mosen-Ansorena D;Mifsu B;Pazoki R;Gao H;Ntritsos G;Dimou N;Cabrer CP;Karaman I;Ng FL;Evangelou M;Witkowska K;Tzanis E;Hellwege JN;Giri A;Edwards DRV;Sun YV;Cho K;Gaziano JM;Wilson PWF;Tsao PS;Kovesdy CP;Esko T;Magi R;Milani L;Almgren P;Boutin T;Debette S;Ding J;Giulianini F;Holliday EG;Jackson AU;Li-Gao R;Lin WY;Luan JA;Mangino M;Oldmeadow C;Prins BP;Qian Y;Sargurupremraj M;Shah N;Surendran P;Theriault S;Verweij N;Willems SM;Zhao JH;Amouyel P;Connell J;de Mutsert R;Doney ASF;Farrall M;C. Menni;Morris AD;Noordam R;Pare G;Poulter NR;Shields DC;Stanton A;Thom S;Abecasis G;Amin N;Arking DE;Ayers KL;Barbieri CM;Batini C;Bis JC;Blake T;Bochud M;Boehnke M;Boerwinkle E;Boomsma DI;Bottinger EP;Braund PS;Brumat M;Campbell A;Campbell H;Chakravarti A;Chambers JC;Chauhan G;Ciullo M;Cocca M;Collins F;Cordell HJ;Davies G;de Borst MH;de Geus EJ;Deary IJ;Deelen J;Del Greco MF;Demirkale CY;Dorr M;Ehret GB;Elosua R;Enroth S;Erzurumluoglu AM;Ferreira T;Franberg M;Franco OH;Gandin I;Gasparini P;Giedraitis V;Gieger C;Girotto G;Goel A;Gow AJ;Gudnason V;Guo XQ;Gyllensten U;Hamsten A;Harris TB;Harris SE;Hartman CA;Havulinna AS;Hicks AA;Hofer E;Hofman A;Hottenga JJ;Huffman JE;Hwang SJ;Ingelsson E;James A;Jansen R;Jarvelin MR;Joehanes R;Johansson A;Johnson AD;Joshi PK;Jousilahti P;Jukema JW;Jula A;Kahonen M;Kathiresan S;Keavney BD;Khaw KT;Knekt P;Knight J;Kolcic I;Kooner JS;Koskinen S;Kristiansson K;Kutalik Z;Laan M;Larson M;Launer LJ;Lehne B;Lehtimaki T;Liewald DCM;Lin L;Lind L;Lindgren CM;Liu YM;Loos RJF;Lopez LM;Lu YC;Lyytikainen LP;Mahajan A;Mamasoula C;Marrugat J;Marten J;Milaneschi Y;Morgan A;Morris AP;Morrison AC;Munson PJ;Nalls MA;Nandakumar P;Nelson CP;Niiranen T;Nolte IM;Nutile T;Oldehinkel AJ;Oostra BA;O'Reilly PF;Org E;Padmanabhan S;Palmas W;Palotie A;Pattie A;Penninx BWJH;Perola M;Peters A;Polasek O;Pramstaller PP;Nguyen QT;Raitakari OT;Ren M;Rettig R;Rice K;Ridker PM;Ried JS;Riese H;Ripatti S;Robino A;Rose LM;Rotter JI;Rudan I;Ruggiero D;Saba Y;Sala CF;Salomaa V;Samani NJ;Sarin AP;Schmidt R;Schmidt H;Shrine N;Siscovick D;Smith AV;Snieder H;Sober S;Sorice R;Starr JM;Stott DJ;Strachan DP;Strawbridge RJ;Sundstrom J;Swertz MA;Taylor KD;Teumer A;Tobin MD;Tomaszewski M;Toniolo D;Traglia M;Trompet S;Tuomilehto J;Tzourio C;Uitterlinden AG;Vaez A;van der Most PJ;van Duijn CM;Vergnaud AC;Verwoert GC;Vitart V;Volker U;Vollenweider P;Vuckovic D;Watkins H;Wild SH;Willemsen G;Wilson JF;Wright AF;Yao J;Zemunik T;Zhang WH;Attia JR;Butterworth AS;Chasman D;Conen D;Cucca F;Danesh J;Hayward C;Howson JMM;Laakso M;Lakatta EG;Langenberg C;Melander O;Mook-Kanamori DO;Palmer CNA;Risch L;Scott RA;Scott RJ;Sever P;Spector TD;van der Harst P;Wareham NJ;Zeggini E;Levy D;Munroe PB;Newton-Cheh C;Brown MJ;Metspalu A;Hung AM;O'Donnell C;Edwards TL;Psaty BM;Tzoulaki I;Barnes MR;Wain LV;Elliott P;Caulfield MJ

2018

Abstract

High blood pressure is a highly heritable and modifiable risk factor for cardiovascular disease. We report the largest genetic association study of blood pressure traits (systolic, diastolic and pulse pressure) to date in over 1 million people of European ancestry. We identify 535 novel blood pressure loci that not only offer new biological insights into blood pressure regulation but also highlight shared genetic architecture between blood pressure and lifestyle exposures. Our findings identify new biological pathways for blood pressure regulation with potential for improved cardiovascular disease prevention in the future.

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				Settore MEDS-24/A - Statistica medica
			
	Data di pubblicazione
	
				2018
			
	Rivista in ANCE
	
				NATURE GENETICS
			
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				https://dx.doi.org/10.1038/s41588-018-0205-x
			
	Tipologia
	
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