Naproxen (NAP) is a non steroidal antinflammatory drug (NSAID) deriving from the propionic acid; in Italy, the NAP is authorized for the use in the man only but the interest for this drug has quickly grown in the race horse, in which the use of this NSAID is rather widespread. In race horses the use of drugs able to modify the acid-base metabolism, inducing an alkalosis, is very frequent. This practice, though illegal, is justified by the fact that the alkalosis improves the elimination of lactic acid, and should improve also, as a secondary effect, the elimination of some acid drugs, like NSAIDS. Purpose of our researches has been therefore to verify the kinetic profile of NAP in horses under normal metabolic conditions and artificially modified (alkalinisation) with the aim to investigate the real influence of this practice on the elimination of the drug. The study has been conducted on 4 standard-bred horses, clinically healthy, of age between 4 and 10 years and with a weight between 300 and 450 kg. Following a cross-over design all the animals have been treated intravenously (IV) with NAP (10 mg.kg-1). The treatment has been conducted in the horses under normal metabolic conditions and, after a period of wash-out of 21 days, in the same subjects with alkalinisation with the IV administration of a water solution of sodium bicarbonate (200-250 mg.kg-1). From every animal blood samples have been collected before the treatment and, subsequently, at prefixed times between 2 minutes and 24 hours. The sera have been analysed with a liquid-liquid extraction and than injected in HPLC for the quantification. On the data obtained the kinetic parameters have been calculated (WinNonLin Prof, Version 4.0.1, Pharsight, Ca, USA). The analysis of the parameters has not underlined meaningful differences in the kinetic behaviour of NAP in the animals under normal metabolic conditions or under conditions artificially modified.
Cinetica del naproxene nel cavallo sportivo: influenza della pratica di alcalinizzazione sui parametri di cinetica ematica / P.A. Barili, R. Villa, P. Cagnardi, A. Zonca, S. Carli - In: Nuove acquisizioni in materia di ippologia : 7. convegno : Lodi, 22-23 giugno 2005 / Universita degli studi del Molise, Societa italiana di ippologia, Universita degli studi di Milano. - [S.l.] : Centro progettazione grafica & stampa dell'Universita degli studi del Molise, 2005. - pp. 356-361 (( Intervento presentato al 7.. convegno Convegno della Società Italiana di Ippologia tenutosi a Lodi nel 2005.
Cinetica del naproxene nel cavallo sportivo: influenza della pratica di alcalinizzazione sui parametri di cinetica ematica
P.A. BariliPrimo
;R. VillaSecondo
;P. Cagnardi;A. ZoncaPenultimo
;S. CarliUltimo
2005
Abstract
Naproxen (NAP) is a non steroidal antinflammatory drug (NSAID) deriving from the propionic acid; in Italy, the NAP is authorized for the use in the man only but the interest for this drug has quickly grown in the race horse, in which the use of this NSAID is rather widespread. In race horses the use of drugs able to modify the acid-base metabolism, inducing an alkalosis, is very frequent. This practice, though illegal, is justified by the fact that the alkalosis improves the elimination of lactic acid, and should improve also, as a secondary effect, the elimination of some acid drugs, like NSAIDS. Purpose of our researches has been therefore to verify the kinetic profile of NAP in horses under normal metabolic conditions and artificially modified (alkalinisation) with the aim to investigate the real influence of this practice on the elimination of the drug. The study has been conducted on 4 standard-bred horses, clinically healthy, of age between 4 and 10 years and with a weight between 300 and 450 kg. Following a cross-over design all the animals have been treated intravenously (IV) with NAP (10 mg.kg-1). The treatment has been conducted in the horses under normal metabolic conditions and, after a period of wash-out of 21 days, in the same subjects with alkalinisation with the IV administration of a water solution of sodium bicarbonate (200-250 mg.kg-1). From every animal blood samples have been collected before the treatment and, subsequently, at prefixed times between 2 minutes and 24 hours. The sera have been analysed with a liquid-liquid extraction and than injected in HPLC for the quantification. On the data obtained the kinetic parameters have been calculated (WinNonLin Prof, Version 4.0.1, Pharsight, Ca, USA). The analysis of the parameters has not underlined meaningful differences in the kinetic behaviour of NAP in the animals under normal metabolic conditions or under conditions artificially modified.
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