A set of novel heterocyclic ligands structurally related to oxotremorine was designed, synthesized, and tested at muscarinic receptor subtypes. The functional in vitro assays yielded results that correlated closely to those obtained from binding experiments.
Synthesis and in Vitro Pharmacology of Novel Heterocyclic Muscarinic Ligands / M. De Amici, P. Conti, E. Fasoli, E. Barocelli, V. Ballabeni, S. Bertoni, M. Impicciatore, B.L. Roth, P. Ernsberger, C. De Micheli. - In: IL FARMACO. - ISSN 0014-827X. - 58:9(2003), pp. 739-748. [10.1016/S0014-827X(03)00113-7]
Synthesis and in Vitro Pharmacology of Novel Heterocyclic Muscarinic Ligands
M. De Amici;P. Conti;C. De Micheli
2003
Abstract
A set of novel heterocyclic ligands structurally related to oxotremorine was designed, synthesized, and tested at muscarinic receptor subtypes. The functional in vitro assays yielded results that correlated closely to those obtained from binding experiments.
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