Recent research has shown that tau protein can be passed to neighboring cells, leading to cellular senescence in the endothelial cells present in the central nervous system (CNS). This discovery could potentially open new doors for testing novel therapeutic compounds that specifically target senescent cells (senolytics) or for identifying new biomarkers that can enable early detection of tauopathies and dementia.
Endothelial cellular senescence and tau accumulation: An interplay full of opportunities? / D. Oliveri, G. Moschetti, A. Griego, E. Scarpa. - In: IBRAIN. - ISSN 2313-1934. - 10:2(2024), pp. 225-230. [10.1002/ibra.12154]
Endothelial cellular senescence and tau accumulation: An interplay full of opportunities?
D. OliveriPrimo
;G. MoschettiSecondo
;A. GriegoPenultimo
;E. Scarpa
Ultimo
2024
Abstract
Recent research has shown that tau protein can be passed to neighboring cells, leading to cellular senescence in the endothelial cells present in the central nervous system (CNS). This discovery could potentially open new doors for testing novel therapeutic compounds that specifically target senescent cells (senolytics) or for identifying new biomarkers that can enable early detection of tauopathies and dementia.
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Ibrain - 2024 - Oliveri - Endothelial cellular senescence and tau accumulation An interplay full of opportunities.pdf
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