Breast computed tomography (BCT) is an emerging application of X-ray tomography in radiological practice. A few clinical prototypes are under evaluation in hospitals and new systems are under development aiming at improving spatial and contrast resolution and reducing delivered dose. At the same time, synchrotron-radiation phase-contrast mammography has been demonstrated to offer substantial advantages when compared with conventional mammography. At Elettra, the Italian synchrotron radiation facility, a clinical program of phase-contrast BCT based on the free-space propagation approach is under development. In this paper, full-volume breast samples imaged with a beam energy of 32 keV delivering a mean glandular dose of 5 mGy are presented. The whole acquisition setup mimics a clinical study in order to evaluate its feasibility in terms of acquisition time and image quality. Acquisitions are performed using a high-resolution CdTe photon-counting detector and the projection data are processed via a phase-retrieval algorithm. Tomographic reconstructions are compared with conventional mammographic images acquired prior to surgery and with histologic examinations. Results indicate that BCT with monochromatic beam and free-space propagation phase-contrast imaging provide relevant three-dimensional insights of breast morphology at clinically acceptable doses and scan times.

Advancements towards the implementation of clinical phase-contrast breast computed tomography at Elettra / R. Longo, F. Arfelli, D. Bonazza, U. Bottigli, L. Brombal, A. Contillo, M.A. Cova, P. Delogu, F. Di Lillo, V. Di Trapani, S. Donato, D. Dreossi, V. Fanti, C. Fedon, B. Golosio, G. Mettivier, P. Oliva, S. Pacile, A. Sarno, L. Rigon, P. Russo, A. Taibi, M. Tonutti, F. Zanconati, G. Tromba. - In: JOURNAL OF SYNCHROTRON RADIATION. - ISSN 0909-0495. - 26:(2019), pp. 1343-1353. [10.1107/S1600577519005502]

Advancements towards the implementation of clinical phase-contrast breast computed tomography at Elettra

A. Sarno;
2019

Abstract

Breast computed tomography (BCT) is an emerging application of X-ray tomography in radiological practice. A few clinical prototypes are under evaluation in hospitals and new systems are under development aiming at improving spatial and contrast resolution and reducing delivered dose. At the same time, synchrotron-radiation phase-contrast mammography has been demonstrated to offer substantial advantages when compared with conventional mammography. At Elettra, the Italian synchrotron radiation facility, a clinical program of phase-contrast BCT based on the free-space propagation approach is under development. In this paper, full-volume breast samples imaged with a beam energy of 32 keV delivering a mean glandular dose of 5 mGy are presented. The whole acquisition setup mimics a clinical study in order to evaluate its feasibility in terms of acquisition time and image quality. Acquisitions are performed using a high-resolution CdTe photon-counting detector and the projection data are processed via a phase-retrieval algorithm. Tomographic reconstructions are compared with conventional mammographic images acquired prior to surgery and with histologic examinations. Results indicate that BCT with monochromatic beam and free-space propagation phase-contrast imaging provide relevant three-dimensional insights of breast morphology at clinically acceptable doses and scan times.
Breast CT; Free space propagation; Phase contrast; Single photon counting
Settore FIS/07 - Fisica Applicata(Beni Culturali, Ambientali, Biol.e Medicin)
2019
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/2434/1071569
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