This PhD research project aimed to investigate immune system functions in healthy and pathologic experimental murine models, through immunohistochemical characterization of immune cell populations in healthy steady state, inflammatory and neoplastic settings. The following fields were investigated: Study I – Mononuclear phagocyte system cells in murine healthy organs and selected pathological conditions. Study II – Sex-dependent modulation of inflammation in a murine caerulein-induced acute pancreatitis model. Study III – Comparison between two methods of digital image analysis (hot-spot fields vs whole-slide) for the assessment of immune cell infiltrations in a murine caerulein-induced acute pancreatitis model. Study IV – Tumor immune system interaction in a murine model of orthotopic pleural mesothelioma.

Characterization of Immune Response in Experimental Mouse Models / L. Bertola ; supervisor: C. Recordati ; cosupervisor: C. Lecchi ; coordinatore: F. Ceciliani. Dipartimento di Medicina Veterinaria e Scienze Animali, 2024 Jul 08. 36. ciclo, Anno Accademico 2023/2024.

CHARACTERIZATION OF IMMUNE RESPONSE IN EXPERIMENTAL MOUSE MODELS

L. Bertola
2024

Abstract

This PhD research project aimed to investigate immune system functions in healthy and pathologic experimental murine models, through immunohistochemical characterization of immune cell populations in healthy steady state, inflammatory and neoplastic settings. The following fields were investigated: Study I – Mononuclear phagocyte system cells in murine healthy organs and selected pathological conditions. Study II – Sex-dependent modulation of inflammation in a murine caerulein-induced acute pancreatitis model. Study III – Comparison between two methods of digital image analysis (hot-spot fields vs whole-slide) for the assessment of immune cell infiltrations in a murine caerulein-induced acute pancreatitis model. Study IV – Tumor immune system interaction in a murine model of orthotopic pleural mesothelioma.
8-lug-2024
Settore VET/03 - Patologia Generale e Anatomia Patologica Veterinaria
CECILIANI, FABRIZIO
Doctoral Thesis
Characterization of Immune Response in Experimental Mouse Models / L. Bertola ; supervisor: C. Recordati ; cosupervisor: C. Lecchi ; coordinatore: F. Ceciliani. Dipartimento di Medicina Veterinaria e Scienze Animali, 2024 Jul 08. 36. ciclo, Anno Accademico 2023/2024.
File in questo prodotto:
File Dimensione Formato  
phd_unimi_R13053.pdf

embargo fino al 01/01/2026

Tipologia: Pre-print (manoscritto inviato all'editore)
Dimensione 4.48 MB
Formato Adobe PDF
4.48 MB Adobe PDF   Visualizza/Apri   Richiedi una copia
Pubblicazioni consigliate

I documenti in IRIS sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.

Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/2434/1068913
Citazioni
  • ???jsp.display-item.citation.pmc??? ND
  • Scopus ND
  • ???jsp.display-item.citation.isi??? ND
social impact