Validating the predictive ability of the 2MACE score for major adverse cardiovascular events in patients with atrial fibrillation: results from phase II/III of the GLORIA-AF registry

Ding, W.Y.; Fawzy, A.M.; Romiti, G.F.; Proietti, M.; Pastori, D.; Huisman, M.V.; Lip, G.Y.H.; Abban, D.W.; Abdul, N.; Abud, A.M.; Adams, F.; Addala, S.; Adragão, P.; Ageno, W.; Aggarwal, R.; Agosti, S.; Agostoni, P.; Aguilar, F.; Linares, J.A.; Aguinaga, L.; Ahmed, J.; Aiello, A.; Ainsworth, P.; Aiub, J.R.; Al-Dallow, R.; Alderson, L.; Velasco, J.A.A.; Alexopoulos, D.; Manterola, F.A.; Aliyar, P.; Alonso, D.; da Costa, F.A.A.; Amado, J.; Amara, W.; Amelot, M.; Amjadi, N.; Ammirati, F.; Andrade, M.; Andrawis, N.; Annoni, G.; Ansalone, G.; Ariani, M.K.; Arias, J.C.; Armero, S.; Arora, C.; Aslam, M.S.; Asselman, M.; Audouin, P.; Augenbraun, C.; Aydin, S.; Ayryanova, I.; Aziz, E.; Backes, L.M.; Badings, E.; Bagni, E.; Baker, S.H.; Bala, R.; Baldi, A.; Bando, S.; Banerjee, S.; Bank, A.; Esquivias, G.B.; Barr, C.; Bartlett, M.; Kes, V.B.; Baula, G.; Behrens, S.; Bell, A.; Benedetti, R.; Mazuecos, J.B.; Benhalima, B.; Bergler-Klein, J.; Berneau, J.; Berrospi, P.; Berti, S.; Berz, A.; Best, E.; Bettencourt, P.; Betzu, R.; Bhagwat, R.; Bhatta, L.; Biscione, F.; Bisignani, G.; Black, T.; Bloch, M.J.; Bloom, S.; Blumberg, E.; Mario, B.; Bøhmer, E.; Bollmann, A.; Bongiorni, M.G.; Boriani, G.; Boswijk, D.J.; Bott, J.; Bottacchi, E.; Kalan, M.B.; Bradman, D.; Brautigam, D.; Breton, N.; Brouwers, P.J.A.M.; Browne, K.; Cortada, J.B.; Bruni, A.; Brunschwig, C.; Buathier, H.; Buhl, A.; Bullinga, J.; Cabrera, J.W.; Caccavo, A.; Cai, S.; Caine, S.; Calò, L.; Calvi, V.; Sánchez, M.C.; Candeias, R.; Capuano, V.; Capucci, A.; Caputo, R.; Rizo, T.C.; Cardona, F.; da Costa Darrieux, F.C.; Vera, Y.C.D.; Carolei, A.; Carreño, S.; Carvalho, P.; Cary, S.; Casu, G.; Cavallini, C.; Cayla, G.; Celentano, A.; Cha, T.; Cha, K.S.; Chae, J.K.; Chalamidas, K.; Challappa, K.; Chand, S.P.; Chandrashekar, H.; Chartier, L.; Chatterjee, K.; Ayala, C.A.C.; Cheema, A.; Cheema, A.; Chen, L.; Chen, S.; Chen, J.H.; Chiang, F.; Chiarella, F.; Chih-Chan, L.; Cho, Y.K.; Choi, J.; Choi, D.J.; Chouinard, G.; Chow, D.H.; Chrysos, D.; Chumakova, G.; Valenzuela, E.J.J.R.C.; Nica, N.C.; Cislowski, D.J.; Clay, A.; Clifford, P.; Cohen, A.; Cohen, M.; Cohen, S.; Colivicchi, F.; Collins, R.; Colonna, P.; Compton, S.; Connolly, D.; Conti, A.; Buenostro, G.C.; Coodley, G.; Cooper, M.; Coronel, J.; Corso, G.; Sales, J.C.; Cottin, Y.; Covalesky, J.; Cracan, A.; Crea, F.; Crean, P.; Crenshaw, J.; Cullen, T.; Darius, H.; Dary, P.; Dascotte, O.; Dauber, I.; Davalos, V.; Davies, R.; Davis, G.; Davy, J.; Dayer, M.; De Biasio, M.; De Bonis, S.; De Caterina, R.; De Franceschi, T.; de Groot, J.R.; De Horta, J.; De La Briolle, A.; de la Pena Topete, G.; de Paola, A.A.V.; de Souza, W.; de Veer, A.; De Wolf, L.; Decoulx, E.; Deepak, S.; Defaye, P.; Munoz, F.D.; Brkljacic, D.D.; Deumite, N.J.; Di Legge, S.; Diemberger, I.; Dietz, D.; Dionísio, P.; Dong, Q.; dos Santos, F.R.; Dotcheva, E.; Doukky, R.; D'Souza, A.; Dubrey, S.; Ducrocq, X.; Dupljakov, D.; Duque, M.; Dutta, D.; Duvilla, N.; Eaton,; Duygun, A.; Rainer Dziewas Charles, B.; Eaves, W.; Ebels-Tuinbeek, L.A.; Ehrlich, C.; Eichinger-Hasenauer, S.; Eisenberg, S.J.; Jabali, A.E.; Shahawy, M.E.; Hernandes, M.E.; Izal, A.E.; Evonich, R.; Evseeva, O.; Ezhov, A.; Fahmy, R.; Fang, Q.; Farsad, R.; Fauchier, L.; Favale, S.; Fayard, M.; Fedele, J.L.; Fedele, F.; Fedorishina, O.; Fera, S.R.; Ferreira, L.G.G.; Ferreira, J.; Ferri, C.; Ferrier, A.; Ferro, H.; Finsen, A.; First, B.; Fischer, S.; Fonseca, C.; Almeida, L.F.; Forman, S.; Frandsen, B.; French, W.; Friedman, K.; Friese, A.; Fruntelata, A.G.; Fujii, S.; Fumagalli, S.; Fundamenski, M.; Furukawa, Y.; Gabelmann, M.; Gabra, N.; Gadsbøll, N.; Galinier, M.; Gammelgaard, A.; Ganeshkumar, P.; Gans, C.; Quintana, A.G.; Gartenlaub, O.; Gaspardone, A.; Genz, C.; Georger, F.; Georges, J.; Georgeson, S.; Giedrimas, E.; Gierba, M.; Ortega, I.G.; Gillespie, E.; Giniger, A.; Giudici, M.C.; Gkotsis, A.; Glotzer, T.V.; Gmehling, J.; Gniot, J.; Goethals, P.; Goldbarg, S.; Goldberg, R.; Goldmann, B.; Golitsyn, S.; Gómez, S.; Mesa, J.G.; Gonzalez, V.B.; Hermosillo, J.A.G.; López, V.M.G.; Gorka, H.; Gornick, C.; Gorog, D.; Gottipaty, V.; Goube, P.; Goudevenos, I.; Graham, B.; Greer, G.S.; Gremmler, U.; Grena, P.G.; Grond, M.; Gronda, E.; Grönefeld, G.; Xiang, G.; Torres Torres, I.G.; Guardigli, G.; Guevara, C.; Guignier, A.; Gulizia, M.; Gumbley, M.; Günther, A.; Andrew, H.; Hahalis, G.; Hakas, J.; Hall, C.; Han, B.; Han, S.; Hargrove, J.; Hargroves, D.; Harris, K.B.; Haruna, T.; Hayek, E.; Healey, J.; Hearne, S.; Heffernan, M.; Heggelund, G.; Heijmeriks, J.A.; Hemels, M.; Hendriks, I.; Henein, S.; Her, S.; Hermany, P.; Del Río, J.E.H.; Higashino, Y.; Hill, M.; Hisadome, T.; Hishida, E.; Hoffer, E.; Hoghton, M.; Hong, K.; Hong, S.K.; Horbach, S.; Horiuchi, M.; Hou, Y.; Hsing, J.; Huang, C.; Huckins, D.; Hughes, K.; Hung,; Huizinga, A.; Hulsman Kuo-Chun, E.L.; Hwang, G.; Ikpoh, M.; Imberti, D.; Ince, H.; Indolfi, C.; Inoue, S.; Irles, D.; Iseki, H.; Israel, C.N.; Iteld, B.; Iyer, V.; Jackson-Voyzey, E.; Jaffrani, N.; Jäger, F.; James, M.; Jang, S.; Jaramillo, N.; Jarmukli, N.; Jeanfreau, R.J.; Jenkins, R.D.; Sánchez, C.J.; Jimenez, J.; Jobe, R.; Joen-Jakobsen, T.; Jones, N.; Jorge, J.C.M.; Jouve, B.; Jung, B.C.; Jung, K.T.; Jung, W.; Kachkovskiy, M.; Kafkala, K.; Kalinina, L.; Kallmünzer, B.; Kamali, F.; Kamo, T.; Kampus, P.; Kashou, H.; Kastrup, A.; Katsivas, A.; Kaufman, E.; Kawai, K.; Kawajiri, K.; Kazmierski, J.F.; Keeling, P.; Saraiva, J.F.K.; Ketova, G.; Khaira, A.S.; Khripun, A.; Kim, D.; Kim, Y.H.; Kim, N.H.; Kim, D.K.; Kim, J.S.; Kim, J.S.; Kim, K.S.; Kim, J.B.; Kinova, E.; Klein, A.; Kmetzo, J.J.; Kneller, G.L.; Knezevic, A.; Koh, S.M.A.; Koide, S.; Kollias, A.; Kooistra, J.A.; Koons, J.; Koschutnik, M.; Kostis, W.J.; Kovacic, D.; Kowalczyk, J.; Koziolova, N.; Kraft, P.; Kragten, J.A.; Krantz, M.; Krause, L.; Krenning, B.J.; Krikke, F.; Kromhout, Z.; Krysiak, W.; Kumar, P.; Kümler, T.; Kuniss, M.; Kuo, J.; Küppers, A.; Kurrelmeyer, K.; Kwak, C.H.; Laboulle, B.; Labovitz, A.; Ter Lai, W.; Lam, A.; Lam, Y.Y.; Zanetti, F.L.; Landau, C.; Landini, G.; Figueiredo, E.L.; Larsen, T.; Lavandier, K.; Leblanc, J.; Lee, M.H.; Lee, C.; Lehman, J.; Leitão, A.; Lellouche, N.; Lelonek, M.; Lenarczyk, R.; Lenderink, T.; González, S.L.; Leong-Sit, P.; Leschke, M.; Ley, N.; Zhanquan, L.; Xiaodong, L.; Weihua, L.; Xiaoming, L.; Lichy, C.; Lieber, I.; Rodriguez, R.H.L.; Lin, H.; Lip, G.Y.H.; Liu, F.; Liu, H.; Esperon, G.L.; Navarro, N.L.; Eric, L.; Lokshyn, S.; López, A.; López-Sendón, J.L.; Filho, A.M.L.; Lorraine, R.S.; Luengas, C.A.; Luke, R.; Luo, M.; Lupovitch, S.; Lyrer, P.; Changsheng, M.; Genshan, M.; Madariaga, I.; Maeno, K.; Magnin, D.; Maid, G.; Mainigi, S.K.; Makaritsis, K.; Malhotra, R.; Manning, R.; Manolis, A.; Hurtado, H.A.M.; Mantas, I.; Jattin, F.M.; Maqueda, V.; Marchionni, N.; Ortuno, F.M.; Santana, A.M.; Martinez, J.; Maskova, P.; Hernandez, N.M.; Matsuda, K.; Maurer, T.; Mauro, C.; May, E.; Mayer, N.; Mcclure, J.; Mccormack, T.; Mcgarity, W.; Mcintyre, H.; Mclaurin, B.; Palomino, F.A.M.; Melandri, F.; Meno, H.; Menzies, D.; Mercader, M.; Meyer, C.; Meyer, B.J.; Miarka, J.; Mibach, F.; Michalski, D.; Michel, P.; Chreih, R.M.; Mikdadi, G.; Mikus, M.; Milicic, D.; Militaru, C.; Minaie, S.; Minescu, B.; Mintale, I.; Mirault, T.; Mirro, M.J.; Mistry, D.; Miu, N.V.; Miyamoto, N.; Moccetti, T.; Mohammed, A.; Nor, A.M.; Mollerus, M.; Molon, G.; Mondillo, S.; Moniz, P.; Mont, L.; Montagud, V.; Montaña, O.; Monti, C.; Moretti, L.; Mori, K.; Moriarty, A.; Morka, J.; Moschini, L.; Moschos, N.; Mügge, A.; Mulhearn, T.J.; Muresan, C.; Muriago, M.; Musial, W.; Musser, C.W.; Musumeci, F.; Nageh, T.; Nakagawa, H.; Nakamura, Y.; Nakayama, T.; Nam, G.; Nanna, M.; Natarajan, I.; Nayak, H.M.; Naydenov, S.; Nazlić, J.; Nechita, A.C.; Nechvatal, L.; Negron, S.A.; Neiman, J.; Neuenschwander, F.C.; Neves, D.; Neykova, A.; Miguel, R.N.; Nijmeh, G.; Nizov, A.; Campos, R.N.; Nossan, J.; Novikova, T.; Nowalany-Kozielska, E.; Nsah, E.; Fragoso, J.C.N.; Nurgalieva, S.; Nuyens, D.; Nyvad, O.; de Los Rios Ibarra, M.O.; O'Donnell, P.; O'Donnell, M.; Seil, O.; Yong Seog, O.; Dongjin, O.; O'Hara, G.; Oikonomou, K.; Olivares, C.; Oliver, R.; Ruiz, R.O.; Olympios, C.; omaszuk-Kazberuk, A.; Asensi, J.O.; Jose, E.P.; Padilla Padilla, F.G.; Rios, V.P.; Pajes, G.; Pandey, A.S.; Paparella, G.; Paris, F.; Park, H.W.; Park, J.S.; Parthenakis, F.; Passamonti, E.; Patel, R.J.; Patel, J.; Patel, M.; Patrick, J.; Jimenez, R.P.; Paz, A.; Pengo, V.; Pentz, W.; Pérez, B.; Ríos, A.M.P.; Pérez-Cabezas, A.; Perlman, R.; Persic, V.; Perticone, F.; Peters, T.K.; Petkar, S.; Pezo, L.F.; Pflücke, C.; Pham, D.N.; Phillips, R.T.; Phlaum, S.; Pieters, D.; Pineau, J.; Pinter, A.; Pinto, F.; Pisters, R.; Pivac, N.; Pocanic, D.; Podoleanu, C.; Politano, A.; Poljakovic, Z.; Pollock, S.; Garcéa, J.P.; Poppert, H.; Porcu, M.; Reino, A.P.; Prasad, N.; Précoma, D.B.; Prelle, A.; Prodafikas, J.; Protasov, K.; Pye, M.; Qiu, Z.; Quedillac, J.; Raev, D.; Grado, C.A.R.; Rahimi, S.; Raisaro, A.; Rama, B.; Ramos, R.; Ranieri, M.; Raposo, N.; Rashba, E.; Rauch-Kroehnert, U.; Reddy, R.; Renda, G.; Reza, S.; Ria, L.; Richter, D.; Rickli, H.; Rieker, W.; Vera, T.R.; Ritt, L.E.; Roberts, D.; Briones, I.R.; Escudero, A.E.R.; Pascual, C.R.; Roman, M.; Romeo, F.; Ronner, E.; Roux, J.; Rozkova, N.; Rubacek, M.; Rubalcava, F.; Russo, A.M.; Rutgers, M.P.; Rybak, K.; Said, S.; Sakamoto, T.; Salacata, A.; Salem, A.; Bodes, R.S.; Saltzman, M.A.; Salvioni, A.; Vallejo, G.S.; Fernández, M.S.; Saporito, W.F.; Sarikonda, K.; Sasaoka, T.; Sati, H.; Savelieva, I.; Scala, P.; Schellinger, P.; Scherr, C.; Schmitz, L.; Schmitz, K.; Schmitz, B.; Schnabel, T.; Schnupp, S.; Schoeniger, P.; Schön, N.; Schwimmbeck, P.; Seamark, C.; Searles, G.; Seidl, K.; Seidman, B.; Sek, J.; Sekaran, L.; Serrati, C.; Shah, N.; Shah, V.; Shah, A.; Shah, S.; Sharma, V.K.; Shaw, L.; Sheikh, K.H.; Shimizu, N.; Shimomura, H.; Shin, D.; Shin, E.; Shite, J.; Sibilio, G.; Silver, F.; Sime, I.; Simmers, T.A.; Singh, N.; Siostrzonek, P.; Smadja, D.; Smith, D.W.; Snitman, M.; Filho, D.S.; Soda, H.; Sofley, C.; Sokal, A.; Yan, Y.S.O.; Sotolongo, R.; de Souza, O.F.; Sparby, J.A.; Spinar, J.; Sprigings, D.; Spyropoulos, A.C.; Stakos, D.; Steinwender, C.; Stergiou, G.; Stiell, I.; Stoddard, M.; Stoikov, A.; Streb, W.; Styliadis, I.; Guohai, S.; Xi, S.; Sudnik, W.; Sukles, K.; Sun, X.; Swart, H.; Szavits-Nossan, J.; Taggeselle, J.; Takagi, Y.; Takhar, A.P.S.; Tamm, A.; Tanaka, K.; Tanawuttiwat, T.; Tang, S.; Tang, A.; Tarsi, G.; Tassinari, T.; Tayal, A.; Tayebjee, M.; Berg, J.M.T.; Tesloianu, D.; The, S.H.K.; Thomas, D.; Timsit, S.; Tobaru, T.; Tomasik., A.R.; Torosoff, M.; Touze, E.; Trendafilova, E.; Tsai, W.K.; Tse, H.F.; Tsutsui, H.; Tian Ming, T.; Tuininga, Y.; Turakhia, M.; Turk, S.; Turner, W.; Tveit, A.; Tytus, R.; Valadão, C.; van Bergen, P.F.M.M.; van de Borne, P.; van den Berg, B.J.; van der Zwaan, C.; Van Eck, M.; Vanacker, P.; Vasilev, D.; Vasilikos, V.; Vasilyev, M.; Veerareddy, S.; Miño, M.V.; Venkataraman, A.; Verdecchia, P.; Versaci, F.; Vester, E.G.; Vial, H.; Victory, J.; Villamil, A.; Vincent, M.; Vlastaris, A.; Dahl, J.V.; Vora, K.; Vranian, R.B.; Wakefield, P.; Wang, N.; Wang, M.; Wang, X.; Wang, F.; Wang, T.; Warner, A.L.; Watanabe, K.; Wei, J.; Weimar, C.; Weiner, S.; Weinrich, R.; Wen, M.; Wiemer, M.; Wiggers, P.; Wilke, A.; Williams, D.; Williams, M.L.; Witzenbichler, B.; Wong, B.; Wong, K.S.L.; Wozakowska-Kaplon, B.; Shulin, W.; Richard C., W.; Wunderlich, S.; Wyatt, N.; Wylie, J.; Yong, X.; Xiangdong, X.; Yamanoue, H.; Yamashita, T.; Yan, P.Y.B.; Yang, T.; Yao, J.; Yeh, K.; Yin, W.H.; Yotov, Y.; Zahn, R.; Zarich, S.; Zenin, S.; Zeuthen, E.L.; Zhang, H.; Zhang, D.; Zhang, X.; Zhang, P.; Zhang, J.; Zhao, S.P.; Zhao, Y.; Zhao, Z.; Zheng, Y.; Zhou, J.; Zimmermann, S.; Zini, A.; Zizzo, S.; Zong, W.; Steven Zukerman, L.; Null, N.

doi:10.1007/s11239-023-02866-y

The 2MACE score was specifically developed as a risk-stratification tool in atrial fibrillation (AF) to predict cardiovascular outcomes. We evaluated the predictive ability of the 2MACE score in the GLORIA-AF registry. All eligible patients from phase II/III of the prospective global GLORIA-AF registry were included. Major adverse cardiac events (MACEs) were defined as the composite outcome of stroke, myocardial infarction and cardiovascular death. Cox proportional hazards were used to examine the relationship between the 2MACE score and study outcomes. Predictive capability of the 2MACE score was investigated using receiver-operating characteristic curves. A total of 25,696 patients were included (mean age 71 years, female 44.9%). Over 3 years, 1583 MACEs were recorded. Patients who had MACE were older, with more cardiovascular risk factors and were less likely to be managed using a rhythm-control strategy. The median 2MACE score in the MACE and non-MACE groups were 2 (IQR 1-3) and 1 (IQR 0-2), respectively (p < 0.001). The 2MACE score was positively associated with an increase in the risk of MACE, with a score of ≥ 2 providing the best combination of sensitivity (69.6%) and specificity (51.6%), HR 2.47 (95% CI, 2.21-2.77). The 2MACE score had modest predictive performance for MACE in patients with AF (AUC 0.655 (95% CI, 0.641-0.669)). Our analysis in this prospective global registry demonstrates that the 2MACE score can adequately predict the risk of MACE (defined as myocardial infarction, CV death and stroke) in patients with AF. Clinical trial registration: http://www.clinicaltrials.gov . Unique identifiers: NCT01468701, NCT01671007 and NCT01937377.

Validating the predictive ability of the 2MACE score for major adverse cardiovascular events in patients with atrial fibrillation: results from phase II/III of the GLORIA-AF registry / W.Y. Ding, A.M. Fawzy, G.F. Romiti, M. Proietti, D. Pastori, M.V. Huisman, G.Y.H. Lip, D.W. Abban, N. Abdul, A.M. Abud, F. Adams, S. Addala, P. Adragão, W. Ageno, R. Aggarwal, S. Agosti, P. Agostoni, F. Aguilar, J.A. Linares, L. Aguinaga, J. Ahmed, A. Aiello, P. Ainsworth, J.R. Aiub, R. Al-Dallow, L. Alderson, J.A.A. Velasco, D. Alexopoulos, F.A. Manterola, P. Aliyar, D. Alonso, F.A.A. da Costa, J. Amado, W. Amara, M. Amelot, N. Amjadi, F. Ammirati, M. Andrade, N. Andrawis, G. Annoni, G. Ansalone, M.K. Ariani, J.C. Arias, S. Armero, C. Arora, M.S. Aslam, M. Asselman, P. Audouin, C. Augenbraun, S. Aydin, I. Ayryanova, E. Aziz, L.M. Backes, E. Badings, E. Bagni, S.H. Baker, R. Bala, A. Baldi, S. Bando, S. Banerjee, A. Bank, G.B. Esquivias, C. Barr, M. Bartlett, V.B. Kes, G. Baula, S. Behrens, A. Bell, R. Benedetti, J.B. Mazuecos, B. Benhalima, J. Bergler-Klein, J. Berneau, P. Berrospi, S. Berti, A. Berz, E. Best, P. Bettencourt, R. Betzu, R. Bhagwat, L. Bhatta, F. Biscione, G. Bisignani, T. Black, M.J. Bloch, S. Bloom, E. Blumberg, M. Bo, E. Bøhmer, A. Bollmann, M.G. Bongiorni, G. Boriani, D.J. Boswijk, J. Bott, E. Bottacchi, M.B. Kalan, D. Bradman, D. Brautigam, N. Breton, P.J.A.M. Brouwers, K. Browne, J.B. Cortada, A. Bruni, C. Brunschwig, H. Buathier, A. Buhl, J. Bullinga, J.W. Cabrera, A. Caccavo, S. Cai, S. Caine, L. Calò, V. Calvi, M.C. Sánchez, R. Candeias, V. Capuano, A. Capucci, R. Caputo, T.C. Rizo, F. Cardona, F.C. da Costa Darrieux, Y.C.D. Vera, A. Carolei, S. Carreño, P. Carvalho, S. Cary, G. Casu, C. Cavallini, G. Cayla, A. Celentano, T. Cha, K.S. Cha, J.K. Chae, K. Chalamidas, K. Challappa, S.P. Chand, H. Chandrashekar, L. Chartier, K. Chatterjee, C.A.C. Ayala, A. Cheema, A. Cheema, L. Chen, S. Chen, J.H. Chen, F. Chiang, F. Chiarella, L. Chih-Chan, Y.K. Cho, J. Choi, D.J. Choi, G. Chouinard, D.H. Chow, D. Chrysos, G. Chumakova, E.J.J.R.C. Valenzuela, N.C. Nica, D.J. Cislowski, A. Clay, P. Clifford, A. Cohen, M. Cohen, S. Cohen, F. Colivicchi, R. Collins, P. Colonna, S. Compton, D. Connolly, A. Conti, G.C. Buenostro, G. Coodley, M. Cooper, J. Coronel, G. Corso, J.C. Sales, Y. Cottin, J. Covalesky, A. Cracan, F. Crea, P. Crean, J. Crenshaw, T. Cullen, H. Darius, P. Dary, O. Dascotte, I. Dauber, V. Davalos, R. Davies, G. Davis, J. Davy, M. Dayer, M. De Biasio, S. De Bonis, R. De Caterina, T. De Franceschi, J.R. de Groot, J. De Horta, A. De La Briolle, G. de la Pena Topete, A.A.V. de Paola, W. de Souza, A. de Veer, L. De Wolf, E. Decoulx, S. Deepak, P. Defaye, F.D. Munoz, D.D. Brkljacic, N.J. Deumite, S. Di Legge, I. Diemberger, D. Dietz, P. Dionísio, Q. Dong, F.R. dos Santos, E. Dotcheva, R. Doukky, A. D'Souza, S. Dubrey, X. Ducrocq, D. Dupljakov, M. Duque, D. Dutta, N. Duvilla, Eaton, D. A., B. Rainer Dziewas Charles, W. Eaves, L.A. Ebels-Tuinbeek, C. Ehrlich, S. Eichinger-Hasenauer, S.J. Eisenberg, A.E. Jabali, M.E. Shahawy, M.E. Hernandes, A.E. Izal, R. Evonich, O. Evseeva, A. Ezhov, R. Fahmy, Q. Fang, R. Farsad, L. Fauchier, S. Favale, M. Fayard, J.L. Fedele, F. Fedele, O. Fedorishina, S.R. Fera, L.G.G. Ferreira, J. Ferreira, C. Ferri, A. Ferrier, H. Ferro, A. Finsen, B. First, S. Fischer, C. Fonseca, L.F. Almeida, S. Forman, B. Frandsen, W. French, K. Friedman, A. Friese, A.G. Fruntelata, S. Fujii, S. Fumagalli, M. Fundamenski, Y. Furukawa, M. Gabelmann, N. Gabra, N. Gadsbøll, M. Galinier, A. Gammelgaard, P. Ganeshkumar, C. Gans, A.G. Quintana, O. Gartenlaub, A. Gaspardone, C. Genz, F. Georger, J. Georges, S. Georgeson, E. Giedrimas, M. Gierba, I.G. Ortega, E. Gillespie, A. Giniger, M.C. Giudici, A. Gkotsis, T.V. Glotzer, J. Gmehling, J. Gniot, P. Goethals, S. Goldbarg, R. Goldberg, B. Goldmann, S. Golitsyn, S. Gómez, J.G. Mesa, V.B. Gonzalez, J.A.G. Hermosillo, V.M.G. López, H. Gorka, C. Gornick, D. Gorog, V. Gottipaty, P. Goube, I. Goudevenos, B. Graham, G.S. Greer, U. Gremmler, P.G. Grena, M. Grond, E. Gronda, G. Grönefeld, X. Gu, I.G. Torres Torres, G. Guardigli, C. Guevara, A. Guignier, M. Gulizia, M. Gumbley, A. Günther, A. Ha, G. Hahalis, J. Hakas, C. Hall, B. Han, S. Han, J. Hargrove, D. Hargroves, K.B. Harris, T. Haruna, E. Hayek, J. Healey, S. Hearne, M. Heffernan, G. Heggelund, J.A. Heijmeriks, M. Hemels, I. Hendriks, S. Henein, S. Her, P. Hermany, J.E.H. Del Río, Y. Higashino, M. Hill, T. Hisadome, E. Hishida, E. Hoffer, M. Hoghton, K. Hong, S.K. Hong, S. Horbach, M. Horiuchi, Y. Hou, J. Hsing, C. Huang, D. Huckins, K. Hughes, Hung, H. A., H.K. E. L., G. Hwang, M. Ikpoh, D. Imberti, H. Ince, C. Indolfi, S. Inoue, D. Irles, H. Iseki, C.N. Israel, B. Iteld, V. Iyer, E. Jackson-Voyzey, N. Jaffrani, F. Jäger, M. James, S. Jang, N. Jaramillo, N. Jarmukli, R.J. Jeanfreau, R.D. Jenkins, C.J. Sánchez, J. Jimenez, R. Jobe, T. Joen-Jakobsen, N. Jones, J.C.M. Jorge, B. Jouve, B.C. Jung, K.T. Jung, W. Jung, M. Kachkovskiy, K. Kafkala, L. Kalinina, B. Kallmünzer, F. Kamali, T. Kamo, P. Kampus, H. Kashou, A. Kastrup, A. Katsivas, E. Kaufman, K. Kawai, K. Kawajiri, J.F. Kazmierski, P. Keeling, J.F.K. Saraiva, G. Ketova, A.S. Khaira, A. Khripun, D. Kim, Y.H. Kim, N.H. Kim, D.K. Kim, J.S. Kim, J.S. Kim, K.S. Kim, J.B. Kim, E. Kinova, A. Klein, J.J. Kmetzo, G.L. Kneller, A. Knezevic, S.M.A. Koh, S. Koide, A. Kollias, J.A. Kooistra, J. Koons, M. Koschutnik, W.J. Kostis, D. Kovacic, J. Kowalczyk, N. Koziolova, P. Kraft, J.A. Kragten, M. Krantz, L. Krause, B.J. Krenning, F. Krikke, Z. Kromhout, W. Krysiak, P. Kumar, T. Kümler, M. Kuniss, J. Kuo, A. Küppers, K. Kurrelmeyer, C.H. Kwak, B. Laboulle, A. Labovitz, W. Ter Lai, A. Lam, Y.Y. Lam, F.L. Zanetti, C. Landau, G. Landini, E.L. Figueiredo, T. Larsen, K. Lavandier, J. Leblanc, M.H. Lee, C. Lee, J. Lehman, A. Leitão, N. Lellouche, M. Lelonek, R. Lenarczyk, T. Lenderink, S.L. González, P. Leong-Sit, M. Leschke, N. Ley, Z. Li, X. Li, W. Li, X. Li, C. Lichy, I. Lieber, R.H.L. Rodriguez, H. Lin, G.Y.H. Lip, F. Liu, H. Liu, G.L. Esperon, N.L. Navarro, E. Lo, S. Lokshyn, A. López, J.L. López-Sendón, A.M.L. Filho, R.S. Lorraine, C.A. Luengas, R. Luke, M. Luo, S. Lupovitch, P. Lyrer, C. Ma, G. Ma, I. Madariaga, K. Maeno, D. Magnin, G. Maid, S.K. Mainigi, K. Makaritsis, R. Malhotra, R. Manning, A. Manolis, H.A.M. Hurtado, I. Mantas, F.M. Jattin, V. Maqueda, N. Marchionni, F.M. Ortuno, A.M. Santana, J. Martinez, P. Maskova, N.M. Hernandez, K. Matsuda, T. Maurer, C. Mauro, E. May, N. Mayer, J. Mcclure, T. Mccormack, W. Mcgarity, H. Mcintyre, B. Mclaurin, F.A.M. Palomino, F. Melandri, H. Meno, D. Menzies, M. Mercader, C. Meyer, B.J. Meyer, J. Miarka, F. Mibach, D. Michalski, P. Michel, R.M. Chreih, G. Mikdadi, M. Mikus, D. Milicic, C. Militaru, S. Minaie, B. Minescu, I. Mintale, T. Mirault, M.J. Mirro, D. Mistry, N.V. Miu, N. Miyamoto, T. Moccetti, A. Mohammed, A.M. Nor, M. Mollerus, G. Molon, S. Mondillo, P. Moniz, L. Mont, V. Montagud, O. Montaña, C. Monti, L. Moretti, K. Mori, A. Moriarty, J. Morka, L. Moschini, N. Moschos, A. Mügge, T.J. Mulhearn, C. Muresan, M. Muriago, W. Musial, C.W. Musser, F. Musumeci, T. Nageh, H. Nakagawa, Y. Nakamura, T. Nakayama, G. Nam, M. Nanna, I. Natarajan, H.M. Nayak, S. Naydenov, J. Nazlić, A.C. Nechita, L. Nechvatal, S.A. Negron, J. Neiman, F.C. Neuenschwander, D. Neves, A. Neykova, R.N. Miguel, G. Nijmeh, A. Nizov, R.N. Campos, J. Nossan, T. Novikova, E. Nowalany-Kozielska, E. Nsah, J.C.N. Fragoso, S. Nurgalieva, D. Nuyens, O. Nyvad, M.O. de Los Rios Ibarra, P. O'Donnell, M. O'Donnell, S. Oh, Y.S. Oh, D. Oh, G. O'Hara, K. Oikonomou, C. Olivares, R. Oliver, R.O. Ruiz, C. Olympios, A. omaszuk-Kazberuk, J.O. Asensi, E.P. Jose, F.G. Padilla Padilla, V.P. Rios, G. Pajes, A.S. Pandey, G. Paparella, F. Paris, H.W. Park, J.S. Park, F. Parthenakis, E. Passamonti, R.J. Patel, J. Patel, M. Patel, J. Patrick, R.P. Jimenez, A. Paz, V. Pengo, W. Pentz, B. Pérez, A.M.P. Ríos, A. Pérez-Cabezas, R. Perlman, V. Persic, F. Perticone, T.K. Peters, S. Petkar, L.F. Pezo, C. Pflücke, D.N. Pham, R.T. Phillips, S. Phlaum, D. Pieters, J. Pineau, A. Pinter, F. Pinto, R. Pisters, N. Pivac, D. Pocanic, C. Podoleanu, A. Politano, Z. Poljakovic, S. Pollock, J.P. Garcéa, H. Poppert, M. Porcu, A.P. Reino, N. Prasad, D.B. Précoma, A. Prelle, J. Prodafikas, K. Protasov, M. Pye, Z. Qiu, J. Quedillac, D. Raev, C.A.R. Grado, S. Rahimi, A. Raisaro, B. Rama, R. Ramos, M. Ranieri, N. Raposo, E. Rashba, U. Rauch-Kroehnert, R. Reddy, G. Renda, S. Reza, L. Ria, D. Richter, H. Rickli, W. Rieker, T.R. Vera, L.E. Ritt, D. Roberts, I.R. Briones, A.E.R. Escudero, C.R. Pascual, M. Roman, F. Romeo, E. Ronner, J. Roux, N. Rozkova, M. Rubacek, F. Rubalcava, A.M. Russo, M.P. Rutgers, K. Rybak, S. Said, T. Sakamoto, A. Salacata, A. Salem, R.S. Bodes, M.A. Saltzman, A. Salvioni, G.S. Vallejo, M.S. Fernández, W.F. Saporito, K. Sarikonda, T. Sasaoka, H. Sati, I. Savelieva, P. Scala, P. Schellinger, C. Scherr, L. Schmitz, K. Schmitz, B. Schmitz, T. Schnabel, S. Schnupp, P. Schoeniger, N. Schön, P. Schwimmbeck, C. Seamark, G. Searles, K. Seidl, B. Seidman, J. Sek, L. Sekaran, C. Serrati, N. Shah, V. Shah, A. Shah, S. Shah, V.K. Sharma, L. Shaw, K.H. Sheikh, N. Shimizu, H. Shimomura, D. Shin, E. Shin, J. Shite, G. Sibilio, F. Silver, I. Sime, T.A. Simmers, N. Singh, P. Siostrzonek, D. Smadja, D.W. Smith, M. Snitman, D.S. Filho, H. Soda, C. Sofley, A. Sokal, Y.S.O. Yan, R. Sotolongo, O.F. de Souza, J.A. Sparby, J. Spinar, D. Sprigings, A.C. Spyropoulos, D. Stakos, C. Steinwender, G. Stergiou, I. Stiell, M. Stoddard, A. Stoikov, W. Streb, I. Styliadis, G. Su, X. Su, W. Sudnik, K. Sukles, X. Sun, H. Swart, J. Szavits-Nossan, J. Taggeselle, Y. Takagi, A.P.S. Takhar, A. Tamm, K. Tanaka, T. Tanawuttiwat, S. Tang, A. Tang, G. Tarsi, T. Tassinari, A. Tayal, M. Tayebjee, J.M.T. Berg, D. Tesloianu, S.H.K. The, D. Thomas, S. Timsit, T. Tobaru, A.R. Tomasik., M. Torosoff, E. Touze, E. Trendafilova, W.K. Tsai, H.F. Tse, H. Tsutsui, T.M. Tu, Y. Tuininga, M. Turakhia, S. Turk, W. Turner, A. Tveit, R. Tytus, C. Valadão, P.F.M.M. van Bergen, P. van de Borne, B.J. van den Berg, C. van der Zwaan, M. Van Eck, P. Vanacker, D. Vasilev, V. Vasilikos, M. Vasilyev, S. Veerareddy, M.V. Miño, A. Venkataraman, P. Verdecchia, F. Versaci, E.G. Vester, H. Vial, J. Victory, A. Villamil, M. Vincent, A. Vlastaris, J.V. Dahl, K. Vora, R.B. Vranian, P. Wakefield, N. Wang, M. Wang, X. Wang, F. Wang, T. Wang, A.L. Warner, K. Watanabe, J. Wei, C. Weimar, S. Weiner, R. Weinrich, M. Wen, M. Wiemer, P. Wiggers, A. Wilke, D. Williams, M.L. Williams, B. Witzenbichler, B. Wong, K.S.L. Wong, B. Wozakowska-Kaplon, S. Wu, R.C. Wu, S. Wunderlich, N. Wyatt, J. Wylie, Y. Xu, X. Xu, H. Yamanoue, T. Yamashita, P.Y.B. Yan, T. Yang, J. Yao, K. Yeh, W.H. Yin, Y. Yotov, R. Zahn, S. Zarich, S. Zenin, E.L. Zeuthen, H. Zhang, D. Zhang, X. Zhang, P. Zhang, J. Zhang, S.P. Zhao, Y. Zhao, Z. Zhao, Y. Zheng, J. Zhou, S. Zimmermann, A. Zini, S. Zizzo, W. Zong, L. Steven Zukerman, N. Null. - In: JOURNAL OF THROMBOSIS AND THROMBOLYSIS. - ISSN 1573-742x. - 57:1(2024 Jan), pp. 39-49. [10.1007/s11239-023-02866-y]

Validating the predictive ability of the 2MACE score for major adverse cardiovascular events in patients with atrial fibrillation: results from phase II/III of the GLORIA-AF registry

Ding, Wern Yew;Fawzy, Ameenathul Mazaya;Romiti, Giulio Francesco;Proietti, Marco;Pastori, Daniele;Huisman, Menno V.;Lip, Gregory Y. H.;Abban, Dzifa Wosornu;Abdul, Nasser;Abud, Atilio Marcelo;Adams, Fran;Addala, Srinivas;Adragão, Pedro;Ageno, Walter;Aggarwal, Rajesh;Agosti, Sergio;P. Agostoni;Aguilar, Francisco;Linares, Julio Aguilar;Aguinaga, Luis;Ahmed, Jameel;Aiello, Allessandro;Ainsworth, Paul;Aiub, Jorge Roberto;Al-Dallow, Raed;Alderson, Lisa;Velasco, Jorge Antonio Aldrete;Alexopoulos, Dimitrios;Manterola, Fernando Alfonso;Aliyar, Pareed;Alonso, David;da Costa, Fernando Augusto Alves;Amado, José;Amara, Walid;Amelot, Mathieu;Amjadi, Nima;Ammirati, Fabrizio;Andrade, Marianna;Andrawis, Nabil;Annoni, Giorgio;Ansalone, Gerardo;Ariani, M. Kevin;Arias, Juan Carlos;Armero, Sébastien;Arora, Chander;Aslam, Muhammad Shakil;Asselman, M.;Audouin, Philippe;Augenbraun, Charles;Aydin, S.;Ayryanova, Ivaneta;Aziz, Emad;Backes, Luciano Marcelo;Badings, E.;Bagni, Ermentina;Baker, Seth H.;Bala, Richard;Baldi, Antonio;Bando, Shigenobu;Banerjee, Subhash;Bank, Alan;Esquivias, Gonzalo Barón;Barr, Craig;Bartlett, Maria;Kes, Vanja Basic;Baula, Giovanni;Behrens, Steffen;Bell, Alan;Benedetti, Raffaella;Mazuecos, Juan Benezet;Benhalima, Bouziane;Bergler-Klein, Jutta;Berneau, Jean-Baptiste;Berrospi, Percy;Berti, Sergio;Berz, Andrea;Best, Elizabeth;Bettencourt, Paulo;Betzu, Robert;Bhagwat, Ravi;Bhatta, Luna;Biscione, Francesco;Bisignani, Giovanni;Black, Toby;Bloch, Michael J.;Bloom, Stephen;Blumberg, Edwin;Bo, Mario;Bøhmer, Ellen;Bollmann, Andreas;Bongiorni, Maria Grazia;Boriani, Giuseppe;Boswijk, D. J.;Bott, Jochen;Bottacchi, Edo;Kalan, Marica Bracic;Bradman, Drew;Brautigam, Donald;Breton, Nicolas;Brouwers, P. J. A. M.;Browne, Kevin;Cortada, Jordi Bruguera;Bruni, A.;Brunschwig, Claude;Buathier, Hervé;Buhl, Aurélie;Bullinga, John;Cabrera, Jose Walter;Caccavo, Alberto;Cai, Shanglang;Caine, Sarah;Calò, Leonardo;Calvi, Valeria;Sánchez, Mauricio Camarillo;Candeias, Rui;Capuano, Vincenzo;Capucci, Alessandro;Caputo, Ronald;Rizo, Tatiana Cárdenas;Cardona, Francisco;da Costa Darrieux, Francisco Carlos;Vera, Yan Carlos Duarte;Carolei, Antonio;Carreño, Susana;Carvalho, Paula;Cary, Susanna;Casu, Gavino;Cavallini, Claudio;Cayla, Guillaume;Celentano, Aldo;Cha, Tae-Joon;Cha, Kwang Soo;Chae, Jei Keon;Chalamidas, Kathrine;Challappa, Krishnan;Chand, Sunil Prakash;Chandrashekar, Harinath;Chartier, Ludovic;Chatterjee, Kausik;Ayala, Carlos Antero Chavez;Cheema, Aamir;Cheema, Amjad;Chen, Lin;Chen, Shih-Ann;Chen, Jyh Hong;Chiang, Fu-Tien;Chiarella, Francesco;Chih-Chan, Lin;Cho, Yong Keun;Choi, Jong-Il;Choi, Dong Ju;Chouinard, Guy;Chow, Danny Hoi-Fan;Chrysos, Dimitrios;Chumakova, Galina;Nica, Nicoleta Cindea;Cislowski, David J.;Clay, Anthony;Clifford, Piers;Cohen, Andrew;Cohen, Michael;Cohen, Serge;Colivicchi, Furio;Collins, Ronan;Colonna, Paolo;Compton, Steve;Connolly, Derek;Conti, Alberto;Buenostro, Gabriel Contreras;Coodley, Gregg;Cooper, Martin;Coronel, Julian;Corso, Giovanni;Sales, Juan Cosín;Cottin, Yves;Covalesky, John;Cracan, Aurel;Crea, Filippo;Crean, Peter;Crenshaw, James;Cullen, Tina;Darius, Harald;Dary, Patrick;Dascotte, Olivier;Dauber, Ira;Davalos, Vicente;Davies, Ruth;Davis, Gershan;Davy, Jean-Marc;Dayer, Mark;De Biasio, Marzia;De Bonis, Silvana;De Caterina, Raffaele;De Franceschi, Teresiano;de Groot, J. R.;De Horta, José;De La Briolle, Axel;de la Pena Topete, Gilberto;de Paola, Angelo Amato Vicenzo;de Souza, Weimar;de Veer, A.;De Wolf, Luc;Decoulx, Eric;Deepak, Sasalu;Defaye, Pascal;Munoz, Freddy Del-Carpio;Brkljacic, Diana Delic;Deumite, N. Joseph;Di Legge, Silvia;Diemberger, Igor;Dietz, Denise;Dionísio, Pedro;Dong, Qiang;dos Santos, Fabio Rossi;Dotcheva, Elena;Doukky, Rami;D'Souza, Anthony;Dubrey, Simon;Ducrocq, Xavier;Dupljakov, Dmitry;Duque, Mauricio;Dutta, Dipankar;Duvilla, Nathalie;Eaton;A. Duygun;Rainer Dziewas Charles B;Eaves, William;Ebels-Tuinbeek, L. A.;Ehrlich, Clifford;Eichinger-Hasenauer, Sabine;Eisenberg, Steven J.;Jabali, Adnan El;Shahawy, Mahfouz El;Hernandes, Mauro Esteves;Izal, Ana Etxeberria;Evonich, Rudolph;Evseeva, Oksana;Ezhov, Andrey;Fahmy, Raed;Fang, Quan;Farsad, Ramin;Fauchier, Laurent;Favale, Stefano;Fayard, Maxime;Fedele, Jose Luis;Fedele, Francesco;Fedorishina, Olga;Fera, Steven R.;Ferreira, Luis Gustavo Gomes;Ferreira, Jorge;Ferri, Claudio;Ferrier, Anna;Ferro, Hugo;Finsen, Alexandra;First, Brian;Fischer, Stuart;Fonseca, Catarina;Almeida, Luísa Fonseca;Forman, Steven;Frandsen, Brad;French, William;Friedman, Keith;Friese, Athena;Fruntelata, Ana Gabriela;Fujii, Shigeru;Fumagalli, Stefano;Fundamenski, Marta;Furukawa, Yutaka;Gabelmann, Matthias;Gabra, Nashwa;Gadsbøll, Niels;Galinier, Michel;Gammelgaard, Anders;Ganeshkumar, Priya;Gans, Christopher;Quintana, Antonio Garcia;Gartenlaub, Olivier;Gaspardone, Achille;Genz, Conrad;Georger, Frédéric;Georges, Jean-Louis;Georgeson, Steven;Giedrimas, Evaldas;Gierba, Mariusz;Ortega, Ignacio Gil;Gillespie, Eve;Giniger, Alberto;Giudici, Michael C.;Gkotsis, Alexandros;Glotzer, Taya V.;Gmehling, Joachim;Gniot, Jacek;Goethals, Peter;Goldbarg, Seth;Goldberg, Ronald;Goldmann, Britta;Golitsyn, Sergey;Gómez, Silvia;Mesa, Juan Gomez;Gonzalez, Vicente Bertomeu;Hermosillo, Jesus Antonio Gonzalez;López, Víctor Manuel González;Gorka, Hervé;Gornick, Charles;Gorog, Diana;Gottipaty, Venkat;Goube, Pascal;Goudevenos, Ioannis;Graham, Brett;Greer, G. Stephen;Gremmler, Uwe;Grena, Paul G.;Grond, Martin;Gronda, Edoardo;Grönefeld, Gerian;Gu, Xiang;Torres Torres, Ivett Guadalupe;Guardigli, Gabriele;Guevara, Carolina;Guignier, Alexandre;Gulizia, Michele;Gumbley, Michael;Günther, Albrecht;Ha, Andrew;Hahalis, Georgios;Hakas, Joseph;Hall, Christian;Han, Bing;Han, Seongwook;Hargrove, Joe;Hargroves, David;Harris, Kenneth B.;Haruna, Tetsuya;Hayek, Emil;Healey, Jeff;Hearne, Steven;Heffernan, Michael;Heggelund, Geir;Heijmeriks, J. A.;Hemels, Maarten;Hendriks, I.;Henein, Sam;Her, Sung-Ho;Hermany, Paul;Del Río, Jorge Eduardo Hernández;Higashino, Yorihiko;Hill, Michael;Hisadome, Tetsuo;Hishida, Eiji;Hoffer, Etienne;Hoghton, Matthew;Hong, Kui;Hong, Suk keun;Horbach, Stevie;Horiuchi, Masataka;Hou, Yinglong;Hsing, Jeff;Huang, Chi-Hung;Huckins, David;Hughes, kathy;Hung;A. Huizinga;E. L. Hulsman Kuo-Chun;Hwang, Gyo-Seung;Ikpoh, Margaret;Imberti, Davide;Ince, Hüseyin;Indolfi, Ciro;Inoue, Shujiro;Irles, Didier;Iseki, Harukazu;Israel, C. Noah;Iteld, Bruce;Iyer, Venkat;Jackson-Voyzey, Ewart;Jaffrani, Naseem;Jäger, Frank;James, Martin;Jang, Sung-Won;Jaramillo, Nicolas;Jarmukli, Nabil;Jeanfreau, Robert J.;Jenkins, Ronald D.;Sánchez, Carlos Jerjes;Jimenez, Javier;Jobe, Robert;Joen-Jakobsen, Tomas;Jones, Nicholas;Jorge, Jose Carlos Moura;Jouve, Bernard;Jung, Byung Chun;Jung, Kyung Tae;Jung, Werner;Kachkovskiy, Mikhail;Kafkala, Krystallenia;Kalinina, Larisa;Kallmünzer, Bernd;Kamali, Farzan;Kamo, Takehiro;Kampus, Priit;Kashou, Hisham;Kastrup, Andreas;Katsivas, Apostolos;Kaufman, Elizabeth;Kawai, Kazuya;Kawajiri, Kenji;Kazmierski, John F.;Keeling, P.;Saraiva, José Francisco Kerr;Ketova, Galina;Khaira, AJIT Singh;Khripun, Aleksey;Kim, Doo-Il;Kim, Young Hoon;Kim, Nam Ho;Kim, Dae Kyeong;Kim, Jeong Su;Kim, June Soo;Kim, Ki Seok;Kim, Jin bae;Kinova, Elena;Klein, Alexander;Kmetzo, James J.;Kneller, G. Larsen;Knezevic, Aleksandar;Koh, Su Mei Angela;Koide, Shunichi;Kollias, Anastasios;Kooistra, J. A.;Koons, Jay;Koschutnik, Martin;Kostis, William J.;Kovacic, Dragan;Kowalczyk, Jacek;Koziolova, Natalya;Kraft, Peter;Kragten, Johannes A.;Krantz, Mori;Krause, Lars;Krenning, B. J.;Krikke, F.;Kromhout, Z.;Krysiak, Waldemar;Kumar, Priya;Kümler, Thomas;Kuniss, Malte;Kuo, Jen-Yuan;Küppers, Achim;Kurrelmeyer, Karla;Kwak, Choong Hwan;Laboulle, Bénédicte;Labovitz, Arthur;Ter Lai, Wen;Lam, Andy;Lam, Yat Yin;Zanetti, Fernando Lanas;Landau, Charles;Landini, Giancarlo;Figueiredo, Estêvão Lanna;Larsen, Torben;Lavandier, Karine;LeBlanc, Jessica;Lee, Moon Hyoung;Lee, Chang-Hoon;Lehman, John;Leitão, Ana;Lellouche, Nicolas;Lelonek, Malgorzata;Lenarczyk, Radoslaw;Lenderink, T.;González, Salvador León;Leong-Sit, Peter;Leschke, Matthias;Ley, Nicolas;Li, Zhanquan;Li, Xiaodong;Li, Weihua;Li, Xiaoming;Lichy, Christhoh;Lieber, Ira;Rodriguez, Ramon Horacio Limon;Lin, Hailong;Lip, Gregory Y. H.;Liu, Feng;Liu, Hengliang;Esperon, Guillermo Llamas;Navarro, Nassip Llerena;Lo, Eric;Lokshyn, Sergiy;López, Amador;López-Sendón, José Luís;Filho, Adalberto Menezes Lorga;Lorraine, Richard S.;Luengas, Carlos Alberto;Luke, Robert;Luo, Ming;Lupovitch, Steven;Lyrer, Philippe;Ma, Changsheng;Ma, Genshan;Madariaga, Irene;Maeno, Koji;Magnin, Dominique;Maid, Gustavo;Mainigi, Sumeet K.;Makaritsis, Konstantinos;Malhotra, Rohit;Manning, Rickey;Manolis, Athanasios;Hurtado, Helard Andres Manrique;Mantas, Ioannis;Jattin, Fernando Manzur;Maqueda, Vicky;Marchionni, Niccolo;Ortuno, Francisco Marin;Santana, Antonio Martín;Martinez, Jorge;Maskova, Petra;Hernandez, Norberto Matadamas;Matsuda, Katsuhiro;Maurer, Tillmann;Mauro, Ciro;May, Erik;Mayer, Nolan;McClure, John;McCormack, Terry;McGarity, William;McIntyre, Hugh;McLaurin, Brent;Palomino, Feliz Alvaro Medina;Melandri, Francesco;Meno, Hiroshi;Menzies, Dhananjai;Mercader, Marco;Meyer, Christian;Meyer, Beat J.;Miarka, Jacek;Mibach, Frank;Michalski, Dominik;Michel, Patrik;Chreih, Rami Mihail;Mikdadi, Ghiath;Mikus, Milan;Milicic, Davor;Militaru, Constantin;Minaie, Sedi;Minescu, Bogdan;Mintale, Iveta;Mirault, Tristan;Mirro, Michael J.;Mistry, Dinesh;Miu, Nicoleta Violeta;Miyamoto, Naomasa;Moccetti, Tiziano;Mohammed, Akber;Nor, Azlisham Mohd;Mollerus, Michael;Molon, Giulio;Mondillo, Sergio;Moniz, Patrícia;Mont, Lluis;Montagud, Vicente;Montaña, Oscar;Monti, Cristina;Moretti, Luciano;Mori, Kiyoo;Moriarty, Andrew;Morka, Jacek;Moschini, Luigi;Moschos, Nikitas;Mügge, Andreas;Mulhearn, Thomas J.;Muresan, Carmen;Muriago, Michela;Musial, Wlodzimierz;Musser, Carl W.;Musumeci, Francesco;Nageh, Thuraia;Nakagawa, Hidemitsu;Nakamura, Yuichiro;Nakayama, Toru;Nam, Gi-Byoung;Nanna, Michele;Natarajan, Indira;Nayak, Hemal M.;Naydenov, Stefan;Nazlić, Jurica;Nechita, Alexandru Cristian;Nechvatal, Libor;Negron, Sandra Adela;Neiman, James;Neuenschwander, Fernando Carvalho;Neves, David;Neykova, Anna;Miguel, Ricardo Nicolás;Nijmeh, George;Nizov, Alexey;Campos, Rodrigo Noronha;Nossan, Janko;Novikova, Tatiana;Nowalany-Kozielska, Ewa;Nsah, Emmanuel;Fragoso, Juan Carlos Nunez;Nurgalieva, Svetlana;Nuyens, Dieter;Nyvad, Ole;de Los Rios Ibarra, Manuel Odin;O'Donnell, Philip;O'Donnell, Martin;Oh, Seil;Oh, Yong Seog;Oh, Dongjin;O'Hara, Gilles;Oikonomou, Kostas;Olivares, Claudia;Oliver, Richard;Ruiz, Rafael Olvera;Olympios, Christoforos;omaszuk-Kazberuk, Anna;Asensi, Joaquín Osca;jose, eena Padayattil;Padilla Padilla, Francisco Gerardo;Rios, Victoria Padilla;Pajes, Giuseppe;Pandey, A. Shekhar;Paparella, Gaetano;Paris, F.;Park, Hyung Wook;Park, Jong Sung;Parthenakis, Fragkiskos;Passamonti, Enrico;Patel, Rajesh J.;Patel, Jaydutt;Patel, Mehool;Patrick, Janice;Jimenez, Ricardo Pavón;Paz, Analía;Pengo, Vittorio;Pentz, William;Pérez, Beatriz;Ríos, Alma Minerva Pérez;Pérez-Cabezas, Alejandro;Perlman, Richard;Persic, Viktor;Perticone, Francesco;Peters, Terri K.;Petkar, Sanjiv;Pezo, Luis Felipe;Pflücke, Christian;Pham, David N.;Phillips, Roland T.;Phlaum, Stephen;Pieters, Denis;Pineau, Julien;Pinter, Arnold;Pinto, Fausto;Pisters, R.;Pivac, Nediljko;Pocanic, Darko;Podoleanu, Cristian;Politano, Alessandro;Poljakovic, Zdravka;Pollock, Stewart;Garcéa, Jose Polo;Poppert, Holger;Porcu, Maurizio;Reino, Antonio Pose;Prasad, Neeraj;Précoma, Dalton Bertolim;Prelle, Alessandro;Prodafikas, John;Protasov, Konstantin;Pye, Maurice;Qiu, Zhaohui;Quedillac, Jean-Michel;Raev, Dimitar;Grado, Carlos Antonio Raffo;Rahimi, Sidiqullah;Raisaro, Arturo;Rama, Bhola;Ramos, Ricardo;Ranieri, Maria;Raposo, Nuno;Rashba, Eric;Rauch-Kroehnert, Ursula;Reddy, Ramakota;Renda, Giulia;Reza, Shabbir;Ria, Luigi;Richter, Dimitrios;Rickli, Hans;Rieker, Werner;Vera, Tomas Ripolil;Ritt, Luiz Eduardo;Roberts, Douglas;Briones, Ignacio Rodriguez;Escudero, Aldo Edwin Rodriguez;Pascual, Carlos Rodríguez;Roman, Mark;Romeo, Francesco;Ronner, E.;Roux, Jean-Francois;Rozkova, Nadezda;Rubacek, Miroslav;Rubalcava, Frank;Russo, Andrea M.;Rutgers, Matthieu Pierre;Rybak, Karin;Said, Samir;Sakamoto, Tamotsu;Salacata, Abraham;Salem, Adrien;Bodes, Rafael Salguero;Saltzman, Marco A.;Salvioni, Alessandro;Vallejo, Gregorio Sanchez;Fernández, Marcelo Sanmartín;Saporito, Wladmir Faustino;Sarikonda, Kesari;Sasaoka, Taishi;Sati, Hamdi;Savelieva, Irina;Scala, Pierre-Jean;Schellinger, Peter;Scherr, Carlos;Schmitz, Lisa;Schmitz, Karl-Heinz;Schmitz, Bettina;Schnabel, Teresa;Schnupp, Steffen;Schoeniger, Peter;Schön, Norbert;Schwimmbeck, Peter;Seamark, Clare;Searles, Greg;Seidl, Karl-Heinz;Seidman, Barry;Sek, Jaroslaw;Sekaran, Lakshmanan;Serrati, Carlo;Shah, Neerav;Shah, Vinay;Shah, Anil;Shah, Shujahat;Sharma, Vijay Kumar;Shaw, Louise;Sheikh, Khalid H.;Shimizu, Naruhito;Shimomura, Hideki;Shin, Dong-Gu;Shin, Eun-Seok;Shite, Junya;Sibilio, Gerolamo;Silver, Frank;Sime, Iveta;Simmers, Tim A.;Singh, Narendra;Siostrzonek, Peter;Smadja, Didier;Smith, David W.;Snitman, Marcelo;Filho, Dario Sobral;Soda, Hassan;Sofley, Carl;Sokal, Adam;Yan, Yannie Soo Oi;Sotolongo, Rodolfo;de Souza, Olga Ferreira;Sparby, Jon Arne;Spinar, Jindrich;Sprigings, David;Spyropoulos, Alex C.;Stakos, Dimitrios;Steinwender, Clemens;Stergiou, Georgios;Stiell, Ian;Stoddard, Marcus;Stoikov, Anastas;Streb, Witold;Styliadis, Ioannis;Su, Guohai;Su, Xi;Sudnik, Wanda;Sukles, Kai;Sun, Xiaofei;Swart, H.;Szavits-Nossan, Janko;Taggeselle, Jens;Takagi, Yuichiro;Takhar, Amrit Pal Singh;Tamm, Angelika;Tanaka, Katsumi;Tanawuttiwat, Tanyanan;Tang, Sherman;Tang, Aylmer;Tarsi, Giovanni;Tassinari, Tiziana;Tayal, Ashis;Tayebjee, Muzahir;Berg, J. M. ten;Tesloianu, Dan;The, Salem H. K.;Thomas, Dierk;Timsit, Serge;Tobaru, Tetsuya;Tomasik. , Andrzej R.;Torosoff, Mikhail;Touze, Emmanuel;Trendafilova, Elina;Tsai, W. Kevin;Tse, Hung Fat;Tsutsui, Hiroshi;Tu, Tian Ming;Tuininga, Ype;Turakhia, Minang;Turk, Samir;Turner, Wayne;Tveit, Arnljot;Tytus, Richard;Valadão, C.;van Bergen, P. F. M. M.;van de Borne, Philippe;van den Berg, B. J.;van der Zwaan, C.;Van Eck, M.;Vanacker, Peter;Vasilev, Dimo;Vasilikos, Vasileios;Vasilyev, Maxim;Veerareddy, Srikar;Miño, Mario Vega;Venkataraman, Asok;Verdecchia, Paolo;Versaci, Francesco;Vester, Ernst Günter;Vial, Hubert;Victory, Jason;Villamil, Alejandro;Vincent, Marc;Vlastaris, Anthony;Dahl, Jürgen vom;Vora, Kishor;Vranian, Robert B.;Wakefield, Paul;Wang, Ningfu;Wang, Mingsheng;Wang, Xinhua;Wang, Feng;Wang, Tian;Warner, Alberta L.;Watanabe, Kouki;Wei, Jeanne;Weimar, Christian;Weiner, Stanislav;Weinrich, Renate;Wen, Ming-Shien;Wiemer, Marcus;Wiggers, Preben;Wilke, Andreas;Williams, David;Williams, Marcus L.;Witzenbichler, Bernhard;Wong, Brian;Wong, Ka Sing Lawrence;Wozakowska-Kaplon, Beata;Wu, Shulin;Wu, Richard C.;Wunderlich, Silke;Wyatt, Nell;Wylie, John;Xu, Yong;Xu, Xiangdong;Yamanoue, Hiroki;Yamashita, Takeshi;Yan, Ping Yen Bryan;Yang, Tianlun;Yao, Jing;Yeh, Kuo-Ho;Yin, Wei Hsian;Yotov, Yoto;Zahn, Ralf;Zarich, Stuart;Zenin, Sergei;Zeuthen, Elisabeth Louise;Zhang, Huanyi;Zhang, Donghui;Zhang, Xingwei;Zhang, Ping;Zhang, Jun;Zhao, Shui Ping;Zhao, Yujie;Zhao, Zhichen;Zheng, Yang;Zhou, Jing;Zimmermann, Sergio;Zini, Andrea;Zizzo, Steven;Zong, Wenxia;Steven Zukerman, L.;null, null

2024

Abstract

The 2MACE score was specifically developed as a risk-stratification tool in atrial fibrillation (AF) to predict cardiovascular outcomes. We evaluated the predictive ability of the 2MACE score in the GLORIA-AF registry. All eligible patients from phase II/III of the prospective global GLORIA-AF registry were included. Major adverse cardiac events (MACEs) were defined as the composite outcome of stroke, myocardial infarction and cardiovascular death. Cox proportional hazards were used to examine the relationship between the 2MACE score and study outcomes. Predictive capability of the 2MACE score was investigated using receiver-operating characteristic curves. A total of 25,696 patients were included (mean age 71 years, female 44.9%). Over 3 years, 1583 MACEs were recorded. Patients who had MACE were older, with more cardiovascular risk factors and were less likely to be managed using a rhythm-control strategy. The median 2MACE score in the MACE and non-MACE groups were 2 (IQR 1-3) and 1 (IQR 0-2), respectively (p < 0.001). The 2MACE score was positively associated with an increase in the risk of MACE, with a score of ≥ 2 providing the best combination of sensitivity (69.6%) and specificity (51.6%), HR 2.47 (95% CI, 2.21-2.77). The 2MACE score had modest predictive performance for MACE in patients with AF (AUC 0.655 (95% CI, 0.641-0.669)). Our analysis in this prospective global registry demonstrates that the 2MACE score can adequately predict the risk of MACE (defined as myocardial infarction, CV death and stroke) in patients with AF. Clinical trial registration: http://www.clinicaltrials.gov . Unique identifiers: NCT01468701, NCT01671007 and NCT01937377.

Scheda breve

Scheda completa

Scheda completa (DC)

	Parole chiave
	
				Atrial fibrillation; Cardiovascular mortality; Myocardial infarction; Risk stratification
			
	Settori scientifico-disciplinari dell'articolo (sola visualizzazione)
	
				Settore MED/11 - Malattie dell'Apparato Cardiovascolare
			
	Data di pubblicazione
	
				gen-2024
			
	Rivista in ANCE
	
				JOURNAL OF THROMBOSIS AND THROMBOLYSIS
			
	DOI
	
				https://dx.doi.org/10.1007/s11239-023-02866-y
			
	Tipologia
	
				Article (author)
			
	Appare nelle tipologie:
	
				01 - Articolo su periodico

File in questo prodotto:

File	Dimensione	Formato
s11239-023-02866-y.pdf accesso aperto Descrizione: Article Tipologia: Publisher's version/PDF Dimensione 875.58 kB Formato Adobe PDF Visualizza/Apri	875.58 kB	Adobe PDF	Visualizza/Apri
s11239-023-02904-9.pdf accesso aperto Descrizione: Correction Tipologia: Publisher's version/PDF Dimensione 425.14 kB Formato Adobe PDF Visualizza/Apri	425.14 kB	Adobe PDF	Visualizza/Apri

Pubblicazioni consigliate

I documenti in IRIS sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.

Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/2434/1066009

Citazioni

ND

1

1

IRIS Institutional Research Information System - AIR Archivio Istituzionale della Ricerca