Scrapie-infected hamsters were tested for spontaneous motor activity and passive avoidance at various times after infection. After testing, some animals were killed and their whole brains assayed for norepinephrine, dopamine, serotonin and their metabolites. The apparent rate of turnover was estimated in terms of metabolite/amine concentrations. After 70 days, there was a decrease in passive avoidance and dopamine and serotonin. Passive avoidance correlated with the apparent rate of turnover of dopamine, whereas motor activity correlated with that of serotonin and dopamine.

Neurochemical and behavioural modifications induced by scrapie infection in golden hamsters / S.R. Bareggi, D. Braida, M. Gervasoni, C. Pollera, G. Carcassola, C. Verzoni, M. Sala. - In: BRAIN RESEARCH. - ISSN 0006-8993. - 984:1-2(2003), pp. 237-241.

Neurochemical and behavioural modifications induced by scrapie infection in golden hamsters

S.R. Bareggi
Primo
;
D. Braida
Secondo
;
M. Gervasoni;C. Pollera;G. Carcassola;M. Sala
Ultimo
2003

Abstract

Scrapie-infected hamsters were tested for spontaneous motor activity and passive avoidance at various times after infection. After testing, some animals were killed and their whole brains assayed for norepinephrine, dopamine, serotonin and their metabolites. The apparent rate of turnover was estimated in terms of metabolite/amine concentrations. After 70 days, there was a decrease in passive avoidance and dopamine and serotonin. Passive avoidance correlated with the apparent rate of turnover of dopamine, whereas motor activity correlated with that of serotonin and dopamine.
Brain monoamine; Motor activity; Neurodegenerative prion disease; Passive avoidance
Settore BIO/14 - Farmacologia
Article (author)
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Utilizza questo identificativo per citare o creare un link a questo documento: http://hdl.handle.net/2434/10652
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