Objective: Many cases of subacute thyroiditis (SAT) have been described related to SARS-CoV-2 infection, but no prospective data about follow-up is known. This prospective, longitudinal, 3-year, multicentre study is aimed at exploring clinical peculiarities and outcome of SAT in relation to SARS-CoV-2 infection, ascertained with antibody dosage. Methods: All patients receiving SAT diagnosis from November 2020 to May 2022 were enrolled. Data about anamnesis, physical examination, blood tests (TSH, freeT4, freeT3, thyroglobulin, anti-thyroid antibodies, C-reactive protein, erythrocyte sedimentation rate, complete blood count), and thyroid ultrasound were collected. At baseline, the presence of IgG against the SARS-CoV-2 spike protein or nucleocapside was investigated. Patients were evaluated after 1, 3, 6, 12 months. Results: Sixty-six subjects were enrolled. At baseline, 54 presented with pain, 36 (67%) for at least 15 days. Serum SARS-CoV-2 IgG measurement documented that 7 out of 52 subjects (13.5%) had infection before SAT diagnosis (Covid+). No significant difference between Covid+ and Covid- groups was found at baseline except for respiratory symptoms and fever, more represented in Covid+ (p=0.039 and p=0.021, respectively). Among the 41 subjects who completed follow-up, Covid+ and Covid- did not differ for therapeutic approach to SAT or outcome, all having an improvement in neck pain, inflammation parameters, and ultrasound features. Conclusions: This is the first prospective study investigating any difference both at diagnosis and at follow-up between SAT presentation in patients with previous SARS-CoV-2 infection and those without. Our data demonstrate that SARS-CoV-2 does not impact on SAT onset, evolution and outcome.

Subacute thyroiditis in the SARS-CoV-2 era: a multicentre prospective study / S. De Vincentis, S. Loiacono, E. Zanni, R. Sueri, M.L. Monzani, D. Santi, I. Muller, F. Di Marco, E. Crivicich, M. Armenti, U. Pagotto, L. Tucci, C. Cecchetti, T. Trenti, V. Pecoraro, G. Canu, M. Simoni, G. Brigante. - In: EUROPEAN THYROID JOURNAL. - ISSN 2235-0640. - 13:3(2024 Jun 24), pp. e240083.1-e240083.9. [10.1530/ETJ-24-0083]

Subacute thyroiditis in the SARS-CoV-2 era: a multicentre prospective study

I. Muller;E. Crivicich;M. Armenti;V. Pecoraro;
2024

Abstract

Objective: Many cases of subacute thyroiditis (SAT) have been described related to SARS-CoV-2 infection, but no prospective data about follow-up is known. This prospective, longitudinal, 3-year, multicentre study is aimed at exploring clinical peculiarities and outcome of SAT in relation to SARS-CoV-2 infection, ascertained with antibody dosage. Methods: All patients receiving SAT diagnosis from November 2020 to May 2022 were enrolled. Data about anamnesis, physical examination, blood tests (TSH, freeT4, freeT3, thyroglobulin, anti-thyroid antibodies, C-reactive protein, erythrocyte sedimentation rate, complete blood count), and thyroid ultrasound were collected. At baseline, the presence of IgG against the SARS-CoV-2 spike protein or nucleocapside was investigated. Patients were evaluated after 1, 3, 6, 12 months. Results: Sixty-six subjects were enrolled. At baseline, 54 presented with pain, 36 (67%) for at least 15 days. Serum SARS-CoV-2 IgG measurement documented that 7 out of 52 subjects (13.5%) had infection before SAT diagnosis (Covid+). No significant difference between Covid+ and Covid- groups was found at baseline except for respiratory symptoms and fever, more represented in Covid+ (p=0.039 and p=0.021, respectively). Among the 41 subjects who completed follow-up, Covid+ and Covid- did not differ for therapeutic approach to SAT or outcome, all having an improvement in neck pain, inflammation parameters, and ultrasound features. Conclusions: This is the first prospective study investigating any difference both at diagnosis and at follow-up between SAT presentation in patients with previous SARS-CoV-2 infection and those without. Our data demonstrate that SARS-CoV-2 does not impact on SAT onset, evolution and outcome.
Settore MED/13 - Endocrinologia
24-giu-2024
5-giu-2024
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/2434/1064628
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