BackgroundLong-acting injectable (LAI) antipsychotics can improve medication adherence and reduce hospitalisation rates compared with oral treatments. Paliperidone palmitate (PAL) and aripiprazole monohydrate (ARI) LAI treatments were associated with improvements in global functioning in patients with schizophrenia. ObjectiveThe objective of this study was to assess the predictive factors of better overall functioning in patients with chronic schizophrenia and schizoaffective disorder treated with PAL and ARI. MethodEnrolled were 143 (97 males, 46 females, mean age 38.24years, SD=12.65) patients with a diagnosis of schizophrenia or schizoaffective disorder, whom we allocated in two groups (PAL and ARI treatments). We assessed global functioning, amount of oral medications, adherence to oral treatment, and number of hospitalisations before LAI introduction and at assessment time point. ResultsLonger treatment time with LAIs (p<.001), lower number of oral drugs (p<.001), and hospitalisations (p=.002) before LAI introduction, and shorter duration of illness (p=.038) predicted better Global Assessment of Functioning scores in the whole sample (R-2=0.337). ConclusionEarly administration and longer duration of ARI or PAL treatments could play a significant role in improving global functioning of patients with schizophrenia and schizoaffective disorder. Better improvement in functioning could be achieved with ARI in young individuals with recent illness onset and PAL in patients at risk for recurrent hospitalisations.

Predictive factors of overall functioning improvement in patients with chronic schizophrenia and schizoaffective disorder treated with paliperidone palmitate and aripiprazole monohydrate / P. Girardi, A. Del Casale, C. Rapinesi, G. Kotzalidis, F. Splendori, C. Verzura, G. Trovini, S. Sorice, D. Carrus, I. Mancinelli, A. Comparelli, S. De Filippis, A. Francomano, A. Ballerini, A. Marcellusi, F. Mennini, G. Ducci, G. Sani, M. Pompili, R. Brugnoli. - In: HUMAN PSYCHOPHARMACOLOGY. - ISSN 0885-6222. - 33:3(2018), pp. e2658.1-e2658.8. [10.1002/hup.2658]

Predictive factors of overall functioning improvement in patients with chronic schizophrenia and schizoaffective disorder treated with paliperidone palmitate and aripiprazole monohydrate.

A. Marcellusi;
2018

Abstract

BackgroundLong-acting injectable (LAI) antipsychotics can improve medication adherence and reduce hospitalisation rates compared with oral treatments. Paliperidone palmitate (PAL) and aripiprazole monohydrate (ARI) LAI treatments were associated with improvements in global functioning in patients with schizophrenia. ObjectiveThe objective of this study was to assess the predictive factors of better overall functioning in patients with chronic schizophrenia and schizoaffective disorder treated with PAL and ARI. MethodEnrolled were 143 (97 males, 46 females, mean age 38.24years, SD=12.65) patients with a diagnosis of schizophrenia or schizoaffective disorder, whom we allocated in two groups (PAL and ARI treatments). We assessed global functioning, amount of oral medications, adherence to oral treatment, and number of hospitalisations before LAI introduction and at assessment time point. ResultsLonger treatment time with LAIs (p<.001), lower number of oral drugs (p<.001), and hospitalisations (p=.002) before LAI introduction, and shorter duration of illness (p=.038) predicted better Global Assessment of Functioning scores in the whole sample (R-2=0.337). ConclusionEarly administration and longer duration of ARI or PAL treatments could play a significant role in improving global functioning of patients with schizophrenia and schizoaffective disorder. Better improvement in functioning could be achieved with ARI in young individuals with recent illness onset and PAL in patients at risk for recurrent hospitalisations.
aripiprazole monohydrate; global assessment of functioning; long-acting injectable antipsychotics; paliperidone palmitate; schizoaffective disorder; schizophrenia;
Settore CHIM/09 - Farmaceutico Tecnologico Applicativo
2018
15-mag-2018
Article (author)
File in questo prodotto:
File Dimensione Formato  
Human Psychopharmacology - 2018 - Girardi - Predictive factors of overall functioning improvement in patients with chronic.pdf

accesso riservato

Tipologia: Publisher's version/PDF
Dimensione 482.36 kB
Formato Adobe PDF
482.36 kB Adobe PDF   Visualizza/Apri   Richiedi una copia
Human Psychopharmacology - 2018 - - Predictive factors of overall functioning improvement in patients with chronic.pdf

accesso riservato

Tipologia: Publisher's version/PDF
Dimensione 42.34 kB
Formato Adobe PDF
42.34 kB Adobe PDF   Visualizza/Apri   Richiedi una copia
Pubblicazioni consigliate

I documenti in IRIS sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.

Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/2434/1057791
Citazioni
  • ???jsp.display-item.citation.pmc??? ND
  • Scopus 15
  • ???jsp.display-item.citation.isi??? 15
social impact