Purpose: Gastric cancer (GC) is among the leading causes of cancer mortality worldwide. The objective of this study was to investigate the association between dietary fiber intake and GC. Methods: We pooled data from 11 population or hospital-based case-control studies included in the Stomach Cancer Pooling (StoP) Project, for a total of 4865 histologically confirmed cases and 10,626 controls. Intake of dietary fibers and other dietary factors was collected using food frequency questionnaires. We calculated the odds ratios (OR) and 95% confidence intervals (CI) of the association between dietary fiber intake and GC by using a multivariable logistic regression model adjusted for study site, sex, age, caloric intake, smoking, fruit and vegetable intake, and socioeconomic status. We conducted stratified analyses by these factors, as well as GC anatomical site and histological type. Results: The OR of GC for an increase of one quartile of fiber intake was 0.91 (95% CI: 0.85, 0.97), that for the highest compared to the lowest quartile of dietary fiber intake was 0.72 (95% CI: 0.59, 0.88). Results were similar irrespective of anatomical site and histological type. Conclusion: Our analysis supports the hypothesis that dietary fiber intake may exert a protective effect on GC.

The association between dietary fiber intake and gastric cancer: a pooled analysis of 11 case–control studies / G. Collatuzzo, J. Cortez Lainez, C. Pelucchi, E. Negri, R. Bonzi, D. Palli, M. Ferraroni, Z. Zhang, G. Yu, N. Lunet, S. Morais, L. López-Carrillo, D. Zaridze, D. Maximovitch, M. Guevara, V. Santos-Sanchez, J. Vioque, M. Garcia de la Hera, M. Ward, R. Malekzadeh, M. Pakseresht, R. Hernández-Ramírez, F. Turati, C. Rabkin, L. Liao, R. Sinha, M. López-Cervantes, S. Tsugane, A. Hidaka, M. Camargo, M. Curado, N. Zubair, D. Kristjansson, S. Shah, C. La Vecchia, P. Boffetta. - In: EUROPEAN JOURNAL OF NUTRITION. - ISSN 1436-6207. - 2024:(2024), pp. 1-9. [Epub ahead of print] [10.1007/s00394-024-03388-w]

The association between dietary fiber intake and gastric cancer: a pooled analysis of 11 case–control studies

C. Pelucchi;E. Negri;R. Bonzi;M. Ferraroni;F. Turati;C. La Vecchia
Penultimo
;
2024

Abstract

Purpose: Gastric cancer (GC) is among the leading causes of cancer mortality worldwide. The objective of this study was to investigate the association between dietary fiber intake and GC. Methods: We pooled data from 11 population or hospital-based case-control studies included in the Stomach Cancer Pooling (StoP) Project, for a total of 4865 histologically confirmed cases and 10,626 controls. Intake of dietary fibers and other dietary factors was collected using food frequency questionnaires. We calculated the odds ratios (OR) and 95% confidence intervals (CI) of the association between dietary fiber intake and GC by using a multivariable logistic regression model adjusted for study site, sex, age, caloric intake, smoking, fruit and vegetable intake, and socioeconomic status. We conducted stratified analyses by these factors, as well as GC anatomical site and histological type. Results: The OR of GC for an increase of one quartile of fiber intake was 0.91 (95% CI: 0.85, 0.97), that for the highest compared to the lowest quartile of dietary fiber intake was 0.72 (95% CI: 0.59, 0.88). Results were similar irrespective of anatomical site and histological type. Conclusion: Our analysis supports the hypothesis that dietary fiber intake may exert a protective effect on GC.
Dietary fiber; Gastric cancer; Gastric neoplasm; Cardia; Non-cardia; Fiber intake
Settore MED/01 - Statistica Medica
Settore MED/06 - Oncologia Medica
2024
30-apr-2024
Article (author)
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/2434/1057695
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