Nocardia is primarily considered an opportunistic pathogen and affects patients with impaired immune systems, solid-organ transplant recipients (SOTRs), and patients with haematologic malignancies. We present the cases of six patients diagnosed with nocardiosis at our center in the last two years, describing the various predisposing conditions alongside the clinical manifestation, the diagnostic workup, and the treatment course. Moreover, we propose a brief literature review on Nocardia infections in the immunocompromised host, focusing on SOTRs and haematopoietic stem cell transplantation recipients and highlighting risk factors, clinical presentations, the diagnostic tools available, and current treatment and prophylaxis guidelines.

Nocardia Infections in the Immunocompromised Host: A Case Series and Literature Review / E. Palomba, A. Liparoti, A. Tonizzo, V. Castelli, L. Alagna, G. Bozzi, R. Ungaro, A. Muscatello, A. Gori, A. Bandera. - In: MICROORGANISMS. - ISSN 2076-2607. - 10:6(2022 May 29), pp. 1120.1-1120.11. [10.3390/microorganisms10061120]

Nocardia Infections in the Immunocompromised Host: A Case Series and Literature Review

E. Palomba
Primo
;
A. Liparoti
Secondo
;
A. Tonizzo;V. Castelli;G. Bozzi;R. Ungaro;A. Gori
Penultimo
;
A. Bandera
Ultimo
2022

Abstract

Nocardia is primarily considered an opportunistic pathogen and affects patients with impaired immune systems, solid-organ transplant recipients (SOTRs), and patients with haematologic malignancies. We present the cases of six patients diagnosed with nocardiosis at our center in the last two years, describing the various predisposing conditions alongside the clinical manifestation, the diagnostic workup, and the treatment course. Moreover, we propose a brief literature review on Nocardia infections in the immunocompromised host, focusing on SOTRs and haematopoietic stem cell transplantation recipients and highlighting risk factors, clinical presentations, the diagnostic tools available, and current treatment and prophylaxis guidelines.
HSCT; SOT; haematologic malignancies; immunocompromised; nocardia; nocardiosis; transplant;
Settore MED/17 - Malattie Infettive
29-mag-2022
Article (author)
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/2434/1049856
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