In October, 2022, WHO published the first fungal priority pathogen list, which categorised 19 fungal entities into three priority groups (critical, high, and medium), for prioritisation of research efforts. The final ranking was determined via multiple criteria decision analysis, considering both research and development needs and perceived public health importance. In this Personal View, we discuss the positioning of the fungal pathogens, namely, Mucorales, Candida spp, Histoplasma spp, Coccidioides and Paracoccidioides spp, Fusarium spp, eumycetoma causative agents, Talaromyces marneffei, and Pneumocystis jirovecii, while expressing concerns about potential disparities between the WHO fungal priority pathogen list ranking and the actual disease burden associated with these pathogens. Finally, we propose a revised prioritisation list that also considers the regional disparities in the burden of fungal diseases.

The WHO fungal priority pathogens list: a crucial reappraisal to review the prioritisation / G. Casalini, A. Giacomelli, S. Antinori. - In: THE LANCET MICROBE. - ISSN 2666-5247. - 5:7(2024 Jul), pp. 717-724. [10.1016/s2666-5247(24)00042-9]

The WHO fungal priority pathogens list: a crucial reappraisal to review the prioritisation

G. Casalini;A. Giacomelli
Secondo
;
S. Antinori
Ultimo
2024

Abstract

In October, 2022, WHO published the first fungal priority pathogen list, which categorised 19 fungal entities into three priority groups (critical, high, and medium), for prioritisation of research efforts. The final ranking was determined via multiple criteria decision analysis, considering both research and development needs and perceived public health importance. In this Personal View, we discuss the positioning of the fungal pathogens, namely, Mucorales, Candida spp, Histoplasma spp, Coccidioides and Paracoccidioides spp, Fusarium spp, eumycetoma causative agents, Talaromyces marneffei, and Pneumocystis jirovecii, while expressing concerns about potential disparities between the WHO fungal priority pathogen list ranking and the actual disease burden associated with these pathogens. Finally, we propose a revised prioritisation list that also considers the regional disparities in the burden of fungal diseases.
Fungal diseases; Candida spp.; Cryptococcus spp.; Histoplasma spp.
Settore MED/17 - Malattie Infettive
Settore MEDS-10/B - Malattie infettive
lug-2024
9-apr-2024
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/2434/1049838
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