Reported herein is a new HPLC-based automated synthesizer (HPLC-A) capable of a temperature-controlled synthesis and purification of carbohydrates. The developed platform allows to perform various protecting group manipulations as well as the synthesis of O- and N-glycosides. A fully automated synthesis and purification was showcased in application to different carbohydrate derivatives including glycosides, oligosaccharides, glycopeptides, glycolipids, and nucleosides.
HPLC-Based Automated Synthesis and Purification of Carbohydrates / G.A. Kashiwagi, L. Petrosilli, S. Escopy, L. Lay, K.J. Stine, C. De Meo, A.V. Demchenko. - In: CHEMISTRY-A EUROPEAN JOURNAL. - ISSN 0947-6539. - (2024), pp. e202401214.1-e202401214.7. [Epub ahead of print] [10.1002/chem.202401214]
HPLC-Based Automated Synthesis and Purification of Carbohydrates
L. PetrosilliSecondo
Investigation
;L. LayConceptualization
;
2024
Abstract
Reported herein is a new HPLC-based automated synthesizer (HPLC-A) capable of a temperature-controlled synthesis and purification of carbohydrates. The developed platform allows to perform various protecting group manipulations as well as the synthesis of O- and N-glycosides. A fully automated synthesis and purification was showcased in application to different carbohydrate derivatives including glycosides, oligosaccharides, glycopeptides, glycolipids, and nucleosides.
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Chemistry A European J - 2024 Accepted article.pdf
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