Two alternative syntheses of 2-oxaadamantan-5-amine, a novel analog of the clinically approved drug amantadine, are reported. The compound has been tested as an anti-influenza A virus agent and as an NMDA receptor antagonist. While the compound was not antivirally active, it displayed moderate activity as an NMDA receptor antagonist.
Ritter reaction-mediated syntheses of 2-oxaadamantan-5-amine, a novel amantadine analog / R. Leiva, S. Gazzarrini, R. Esplugas, A. Moroni, L. Naesens, F.X. Sureda, S. Vazquez. - In: TETRAHEDRON LETTERS. - ISSN 0040-4039. - 56:10(2015 Mar), pp. 1272-1275. [10.1016/j.tetlet.2015.01.160]
Ritter reaction-mediated syntheses of 2-oxaadamantan-5-amine, a novel amantadine analog
S. GazzarriniSecondo
;A. Moroni;
2015
Abstract
Two alternative syntheses of 2-oxaadamantan-5-amine, a novel analog of the clinically approved drug amantadine, are reported. The compound has been tested as an anti-influenza A virus agent and as an NMDA receptor antagonist. While the compound was not antivirally active, it displayed moderate activity as an NMDA receptor antagonist.
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