Diabetic retinopathy (DR) is a significant cause of vision loss and preventable blindness in adults worldwide. The currently available treatments, which include intravitreal anti-VEGF agents and steroids, laser photocoagulation, and vitrectomy, reflect the complex pathogenesis of DR. Even though clinical benefits are reported, none of these options is yet to entirely mitigate the progression or reverse retinal damage in DR. Therefore, several alternative molecular mechanisms underlying the pathophysiology of DR and novel routes of administration have been considered as potential therapeutic targets for the condition. This chapter discusses the current status of novel treatment strategies under investigation for DR and diabetic macular edema.
Diabetic eye disease: novel therapeutic strategies / S. Vujosevic - In: Chronic Complications of Diabetes Mellitus : Current Outlook and Novel Pathophysiological Insights / [a cura di] D. Mauricio, N. Alonso. - [s.l] : Academic Press, 2024 Mar 21. - ISBN 978-0-323-88426-6. - pp. 279-294 [10.1016/B978-0-323-88426-6.00007-5]
Diabetic eye disease: novel therapeutic strategies
S. Vujosevic
2024
Abstract
Diabetic retinopathy (DR) is a significant cause of vision loss and preventable blindness in adults worldwide. The currently available treatments, which include intravitreal anti-VEGF agents and steroids, laser photocoagulation, and vitrectomy, reflect the complex pathogenesis of DR. Even though clinical benefits are reported, none of these options is yet to entirely mitigate the progression or reverse retinal damage in DR. Therefore, several alternative molecular mechanisms underlying the pathophysiology of DR and novel routes of administration have been considered as potential therapeutic targets for the condition. This chapter discusses the current status of novel treatment strategies under investigation for DR and diabetic macular edema.File | Dimensione | Formato | |
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