The WHO Classification of Tumors, Thoracic Tumors, 5th edition, has outlined the use of TTF-1 and ΔNP63/P40 to discriminate between adenocarcinoma and squamous cell carcinoma. In 2015, the first description of a rare non-small cell lung carcinoma featuring co-expression of glandular and squamous differentiation within most of the same individual tumor cells was reported on, with ultrastructural and molecular demonstration of such a biphenotypic differentiation. We herein describe an additional case of this rare tumor entity, which is confirmed to be an aggressive neoplasm despite potential targets of therapy.

Biphenotypic lung carcinoma with coexpression of TTF-1 and ΔNP63/P40 within most of the same individual cells: a further case confirming poor prognosis and a review of literature / A. Marando, M. Zagni, M. Negrelli, E. Valtorta, C. Lauricella, V. Motta, S. Veronese, G. Cerea, L.G. Giannetta, G. Ciarlo, D. Signorelli, E.G. Pizzutilo, E. Bonoldi, G. Pelosi. - In: PATHOLOGICA. - ISSN 1591-951X. - 116:1(2024 Feb), pp. 13-21. [10.32074/1591-951X-957]

Biphenotypic lung carcinoma with coexpression of TTF-1 and ΔNP63/P40 within most of the same individual cells: a further case confirming poor prognosis and a review of literature

M. Zagni;M. Negrelli;G. Ciarlo;E.G. Pizzutilo;G. Pelosi
Ultimo
2024

Abstract

The WHO Classification of Tumors, Thoracic Tumors, 5th edition, has outlined the use of TTF-1 and ΔNP63/P40 to discriminate between adenocarcinoma and squamous cell carcinoma. In 2015, the first description of a rare non-small cell lung carcinoma featuring co-expression of glandular and squamous differentiation within most of the same individual tumor cells was reported on, with ultrastructural and molecular demonstration of such a biphenotypic differentiation. We herein describe an additional case of this rare tumor entity, which is confirmed to be an aggressive neoplasm despite potential targets of therapy.
biphenotypic lung cancer; lung adenocarcinoma; lung adenosquamous carcinoma; lung cancer immunohistochemistry; lung squamous cell carcinoma;
Settore MED/06 - Oncologia Medica
Settore MED/08 - Anatomia Patologica
feb-2024
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/2434/1046973
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