Agricultural crops are targeted by various pathogens (fungi, bacteria, and viruses) and pests (herbivorous arthropods). Antimicrobial and insecticidal peptides are increasingly recognized as eco-friendly tools for crop protection due to their low propensity for resistance development and the fact that they are fully biodegradable. However, historical challenges have hindered their development, including poor stability, limited availability, reproducibility issues, high production costs, and unwanted toxicity. Toxicity is a primary concern because crop-protective peptides interact with various organisms of environmental and economic significance. This review focuses on the potential of genetically encoded peptide libraries like the use of two-hybrid-based methods for antimicrobial peptides identification and insecticidal spider venom peptides as two main approaches for targeting plant pathogens and pests. We discuss some key findings and challenges regarding the practical application of each strategy. We conclude that genetically encoded peptide library- and spider venom-derived crop protective peptides offer a sustainable and environmentally responsible approach for addressing modern crop protection needs in the agricultural sector.

Genetically encoded libraries and spider venoms as emerging sources for crop protective peptides / E.M. Fassolo, S. Guo, Y. Wang, S. Rosa, V. Herzig. - In: JOURNAL OF PEPTIDE SCIENCE. - ISSN 1075-2617. - (2024), pp. e3600.1-e3600.9. [10.1002/psc.3600]

Genetically encoded libraries and spider venoms as emerging sources for crop protective peptides

E.M. Fassolo
Co-primo
;
S. Rosa
;
2024

Abstract

Agricultural crops are targeted by various pathogens (fungi, bacteria, and viruses) and pests (herbivorous arthropods). Antimicrobial and insecticidal peptides are increasingly recognized as eco-friendly tools for crop protection due to their low propensity for resistance development and the fact that they are fully biodegradable. However, historical challenges have hindered their development, including poor stability, limited availability, reproducibility issues, high production costs, and unwanted toxicity. Toxicity is a primary concern because crop-protective peptides interact with various organisms of environmental and economic significance. This review focuses on the potential of genetically encoded peptide libraries like the use of two-hybrid-based methods for antimicrobial peptides identification and insecticidal spider venom peptides as two main approaches for targeting plant pathogens and pests. We discuss some key findings and challenges regarding the practical application of each strategy. We conclude that genetically encoded peptide library- and spider venom-derived crop protective peptides offer a sustainable and environmentally responsible approach for addressing modern crop protection needs in the agricultural sector.
antimicrobial peptides; bioinsecticides; crop protection; genetically encoded peptide libraries; pesticides; spider venom peptides; two‐hybrid assays
Settore BIO/11 - Biologia Molecolare
   Novel Pesticides for a Sustainable Agriculture (NoPest)
   NoPest
   EUROPEAN COMMISSION
   H2020
   828940

   Small RNAs and peptides for controlling diseases and development in horticultural plants
   MINISTERO DELL'ISTRUZIONE E DEL MERITO
   20173LBZM2_005
2024
16-apr-2024
Article (author)
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/2434/1046273
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