Receptor for AGE (RAGE) is a member of the immunoglobulin superfamily that engages distinct classes of ligands. The biology of RAGE is driven by the settings in which these ligands accumulate, such as diabetes, inflammation, neurodegenerative disorders and tumors. In this review, we discuss the context of each of these classes of ligands, including advance glycation end-products, amyloid beta peptide and the family of beta sheet fibrils, S100/calgranulins and amphoterin. Implications for the role of these ligands interacting with RAGE in homeostasis and disease will be considered.
RAGE is a multiligand receptor of the immunoglobulin superfamily: implications for homeostasis and chronic disease / L. Bucciarelli, T. Wendt, L. Rong, E. Lalla, M. Hofmann, M. Goova, A. Taguchi, S. Yan, S. Yan, D. Stern, A. Schmidt. - In: CELLULAR AND MOLECULAR LIFE SCIENCES. - ISSN 1420-682X. - 59:7(2002 Jul), pp. 1117-1128. [10.1007/s00018-002-8491-x]
RAGE is a multiligand receptor of the immunoglobulin superfamily: implications for homeostasis and chronic disease
L. BucciarelliPrimo
;
2002
Abstract
Receptor for AGE (RAGE) is a member of the immunoglobulin superfamily that engages distinct classes of ligands. The biology of RAGE is driven by the settings in which these ligands accumulate, such as diabetes, inflammation, neurodegenerative disorders and tumors. In this review, we discuss the context of each of these classes of ligands, including advance glycation end-products, amyloid beta peptide and the family of beta sheet fibrils, S100/calgranulins and amphoterin. Implications for the role of these ligands interacting with RAGE in homeostasis and disease will be considered.
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