Ain't got that swing(-out): The cyclopeptide isoDGR is emerging as a new αvβ3 integrin binding motif. Agreement between the results of computational and biochemical studies reveals that isoDGR-containing cyclopeptides are true αvβ3 integrin antagonists that block αvβ3 in its inactive conformation (see scheme). isoDGR-based ligands may give αvβ3 antagonists without paradoxical effects.
Molecular Dynamics Reveal that isoDGR-Containing Cyclopeptides Are True αvβ3 Antagonists Unable To Promote Integrin Allostery and Activation / M. Ghitti, A. Spitaleri, B. Valentinis, S. Mari, C. Asperti, C. Traversari, G.P. Rizzardi, G. Musco. - In: ANGEWANDTE CHEMIE. INTERNATIONAL EDITION. - ISSN 1433-7851. - 51:31(2012 Jul 27), pp. 7825.7702-7825.7705. [10.1002/ange.201202032]
Molecular Dynamics Reveal that isoDGR-Containing Cyclopeptides Are True αvβ3 Antagonists Unable To Promote Integrin Allostery and Activation
A. SpitaleriSecondo
;
2012
Abstract
Ain't got that swing(-out): The cyclopeptide isoDGR is emerging as a new αvβ3 integrin binding motif. Agreement between the results of computational and biochemical studies reveals that isoDGR-containing cyclopeptides are true αvβ3 integrin antagonists that block αvβ3 in its inactive conformation (see scheme). isoDGR-based ligands may give αvβ3 antagonists without paradoxical effects.
| File | Dimensione | Formato | |
|---|---|---|---|
|
Angew Chem Int Ed - 2012 - Ghitti - Molecular Dynamics Reveal that isoDGR‐Containing Cyclopeptides Are True v 3.pdf
accesso riservato
Tipologia:
Publisher's version/PDF
Dimensione
3.65 MB
Formato
Adobe PDF
|
3.65 MB | Adobe PDF | Visualizza/Apri Richiedi una copia |
Pubblicazioni consigliate
I documenti in IRIS sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.
