The presence of subclones of tumor cells with a more aggressive phenotype and their role in metastasis are discussed in this chapter. Phenotypic plasticity of tumor cells has an important role for immune surveillance and here we show how it impacts metastasis. Another important issue is the appearance of metastasis as an independent disease, where on one side, the possibility to hit the plasticity of tumor cells and on the other side, the microenvironment can lead to a successful therapeutic strategy.
Phenotypic plasticity: The emergence of cancer stem cells, collective cell migration, and the impact on immune surveillance / C.A.M. LA PORTA - In: Successes and challenges of NK immunotherapy: breaking tolerance to cancer resistance / [a cura di] B. Bonavida, A. Jewett. - London : Elsevier, 2021. - ISBN 9780128243756. - pp. 183-190 [10.1016/B978-0-12-824375-6.00009-6]
Phenotypic plasticity: The emergence of cancer stem cells, collective cell migration, and the impact on immune surveillance
C.A.M. LA PORTA
2021
Abstract
The presence of subclones of tumor cells with a more aggressive phenotype and their role in metastasis are discussed in this chapter. Phenotypic plasticity of tumor cells has an important role for immune surveillance and here we show how it impacts metastasis. Another important issue is the appearance of metastasis as an independent disease, where on one side, the possibility to hit the plasticity of tumor cells and on the other side, the microenvironment can lead to a successful therapeutic strategy.
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