Cell type-specific and housekeeping enhancers and promoters collectively control the transcriptional output of mammalian cells. Recent data clarify how DNA sequence features on the one hand control functional coupling of promoters with selected enhancers, and on the other impart high level of activity to a broad range of regulatory elements.
Housekeeping and tissue-specific cis-regulatory elements: Recipes for specificity and recipes for activity / M. Russo, G. Natoli, S. Ghisletti. - In: TRANSCRIPTION. - ISSN 2154-1264. - 9:3(2018), pp. 177-181. [10.1080/21541264.2017.1378158]
Housekeeping and tissue-specific cis-regulatory elements: Recipes for specificity and recipes for activity
S. Ghisletti
2018
Abstract
Cell type-specific and housekeeping enhancers and promoters collectively control the transcriptional output of mammalian cells. Recent data clarify how DNA sequence features on the one hand control functional coupling of promoters with selected enhancers, and on the other impart high level of activity to a broad range of regulatory elements.
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