Breastmilk protects newborns from infections through specific and nonspecific compounds. This study investigated the neutralizing activity against SARS-CoV-2 of breastmilk from SARS-CoV-2 negative, unvaccinated mothers, and compared it to that from infected nursing mothers. We enrolled women after COVID-19 swab testing results upon maternity admission, and divided them into two groups: group A, COVID-19-positive mothers, and group B, negative mothers. Breastmilk was randomly sampled at 2, 7, and 20 days postpartum. We collected 19 samples for Group A and 41 for Group B. A microneutralization assay was used to determine the 50% neutralization (NT50) titre. The presence of neutralizing antibodies was also determined. Group A had 100% neutralizing samples at 2 days postpartum (T0), declining 7 days postpartum (T1) and 20 days postpartum (T2). Group B samples exhibited neutralizing activity mostly at 7 days postpartum (T1) (90%). Negative mothers' samples showed no correlation between NT50 titres and antibodies' presence, suggesting that non-specific breastmilk components may exert antiviral action against SARS-CoV-2.
Breastmilk from COVID-19 negative lactating mothers shows neutralizing activity against SARS-COV-2 / D. Morniroli, L. Signorini, M. Dolci, G. Vizzari, A. Ronchi, C. Pietrasanta, L. Pugni, F. Mosca, S. Delbue, M.L. Gianni. - In: SCIENTIFIC REPORTS. - ISSN 2045-2322. - 13:1(2023), pp. 15521.1-15521.7. [10.1038/s41598-023-42421-6]
Breastmilk from COVID-19 negative lactating mothers shows neutralizing activity against SARS-COV-2
D. Morniroli
Co-primo
;L. SignoriniCo-primo
;M. Dolci;G. Vizzari;A. Ronchi;C. Pietrasanta;L. Pugni;F. Mosca;S. DelbueCo-ultimo
;M.L. GianniCo-ultimo
2023
Abstract
Breastmilk protects newborns from infections through specific and nonspecific compounds. This study investigated the neutralizing activity against SARS-CoV-2 of breastmilk from SARS-CoV-2 negative, unvaccinated mothers, and compared it to that from infected nursing mothers. We enrolled women after COVID-19 swab testing results upon maternity admission, and divided them into two groups: group A, COVID-19-positive mothers, and group B, negative mothers. Breastmilk was randomly sampled at 2, 7, and 20 days postpartum. We collected 19 samples for Group A and 41 for Group B. A microneutralization assay was used to determine the 50% neutralization (NT50) titre. The presence of neutralizing antibodies was also determined. Group A had 100% neutralizing samples at 2 days postpartum (T0), declining 7 days postpartum (T1) and 20 days postpartum (T2). Group B samples exhibited neutralizing activity mostly at 7 days postpartum (T1) (90%). Negative mothers' samples showed no correlation between NT50 titres and antibodies' presence, suggesting that non-specific breastmilk components may exert antiviral action against SARS-CoV-2.File | Dimensione | Formato | |
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