Ambient air pollution increases the risk of respiratory mortality, but evidence for impacts on lung function and chronic obstructive pulmonary disease (COPD) is less well established. The aim was to evaluate whether ambient air pollution is associated with lung function and COPD, and explore potential vulnerability factors. We used UK Biobank data on 303887 individuals aged 40-69 years, with complete covariate data and valid lung function measures. Cross-sectional analyses examined associations of land use regression-based estimates of particulate matter (particles with a 50% cut-off aerodynamic diameter of 2.5 and 10 µm: PM2.5 and PM10, respectively; and coarse particles with diameter between 2.5 μm and 10 μm: PMcoarse) and nitrogen dioxide (NO2) concentrations with forced expiratory volume in 1 s (FEV1), forced vital capacity (FVC), the FEV1/FVC ratio and COPD (FEV1/FVC

Air pollution, lung function and COPD: results from the population-based UK Biobank study / D. Doiron, K. de Hoogh, N. Probst-Hensch, I. Fortier, Y. Cai, S. De Matteis, A.L. Hansell. - In: EUROPEAN RESPIRATORY JOURNAL. - ISSN 1399-3003. - 54:1(2019 Jul), pp. 1802140.1-1802140.12. [10.1183/13993003.02140-2018]

Air pollution, lung function and COPD: results from the population-based UK Biobank study

S. De Matteis
Penultimo
;
2019

Abstract

Ambient air pollution increases the risk of respiratory mortality, but evidence for impacts on lung function and chronic obstructive pulmonary disease (COPD) is less well established. The aim was to evaluate whether ambient air pollution is associated with lung function and COPD, and explore potential vulnerability factors. We used UK Biobank data on 303887 individuals aged 40-69 years, with complete covariate data and valid lung function measures. Cross-sectional analyses examined associations of land use regression-based estimates of particulate matter (particles with a 50% cut-off aerodynamic diameter of 2.5 and 10 µm: PM2.5 and PM10, respectively; and coarse particles with diameter between 2.5 μm and 10 μm: PMcoarse) and nitrogen dioxide (NO2) concentrations with forced expiratory volume in 1 s (FEV1), forced vital capacity (FVC), the FEV1/FVC ratio and COPD (FEV1/FVC
adult; aged; air pollutants; air pollutants; air pollution; biological specimen banks; cross-sectional studies; environmental exposure; female; humans; male; middle aged; nitrogen dioxide; particulate matter; prevalence; pulmonary disease; chronic obstructive; regression analysis; respiratory function tests; risk factors; United Kingdom
Settore MED/44 - Medicina del Lavoro
lug-2019
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/2434/1025541
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