Background: Aspirin intake might be inversely associated with head and neck cancer (HNC). Thus, we investigated this relationship within the International Head and Neck Cancer Epidemiology (INHANCE) consortium. Methods: Four case-control studies within the INHANCE consortium were included (2024 cases, 4196 controls). Study-specific odds ratios (ORs) and 95% confidence intervals (CIs) were estimated using logistic regression and subsequently pooled with DerSimonian-Laird random-effects model. Nonlinearity of the relationship between duration of intake and HNC was modeled with fractional polynomials. Results: Aspirin was inversely associated with HNC overall (OR = 0.48; 95% CI: 0.26, 0.91). Results for laryngeal cancer were similar (OR = 0.54; 95% CI: 0.30, 0.96). Analysis on duration of intake confirmed findings for HNC overall, showing also inverse associations for oropharyngeal and laryngeal cancer. Conclusions: This study suggests that aspirin intake may reduce the risk of HNC, driven mainly by decreases in risk for laryngeal and oropharyngeal cancer.

Aspirin intake and head and neck cancer: A pooled analysis within the INHANCE consortium / M. Sassano, M. Taborelli, S. Boccia, G. Cadoni, C. La Vecchia, W. Garavello, P. Lazarus, A.Y. Lee, M. Hashibe, P. Boffetta. - In: HEAD & NECK. - ISSN 1043-3074. - (2024), pp. 1-10. [Epub ahead of print] [10.1002/hed.27638]

Aspirin intake and head and neck cancer: A pooled analysis within the INHANCE consortium

C. La Vecchia;
2024

Abstract

Background: Aspirin intake might be inversely associated with head and neck cancer (HNC). Thus, we investigated this relationship within the International Head and Neck Cancer Epidemiology (INHANCE) consortium. Methods: Four case-control studies within the INHANCE consortium were included (2024 cases, 4196 controls). Study-specific odds ratios (ORs) and 95% confidence intervals (CIs) were estimated using logistic regression and subsequently pooled with DerSimonian-Laird random-effects model. Nonlinearity of the relationship between duration of intake and HNC was modeled with fractional polynomials. Results: Aspirin was inversely associated with HNC overall (OR = 0.48; 95% CI: 0.26, 0.91). Results for laryngeal cancer were similar (OR = 0.54; 95% CI: 0.30, 0.96). Analysis on duration of intake confirmed findings for HNC overall, showing also inverse associations for oropharyngeal and laryngeal cancer. Conclusions: This study suggests that aspirin intake may reduce the risk of HNC, driven mainly by decreases in risk for laryngeal and oropharyngeal cancer.
aspirin; case-control; consortia; head and neck cancer
Settore MED/01 - Statistica Medica
Settore MED/06 - Oncologia Medica
Settore MED/31 - Otorinolaringoiatria
Settore MED/42 - Igiene Generale e Applicata
   INHANCE Consortium
   National Institutes of Health
   NATIONAL CANCER INSTITUTE
   5R13CA210555-02

   Fattori ormonali, esogeni ed endogeni, fattori ormono-relati, familiarità e rischio di neoplasie maligne nelle donne.
   MINISTERO DELL'ISTRUZIONE E DEL MERITO
   2009X8YCBN_003
2024
16-gen-2024
Article (author)
File in questo prodotto:
File Dimensione Formato  
Aspitrin INHANCE head and neck ca_Sassano M.pdf

accesso riservato

Descrizione: Original Article
Tipologia: Publisher's version/PDF
Dimensione 2.03 MB
Formato Adobe PDF
2.03 MB Adobe PDF   Visualizza/Apri   Richiedi una copia
Pubblicazioni consigliate

I documenti in IRIS sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.

Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/2434/1024408
Citazioni
  • ???jsp.display-item.citation.pmc??? 0
  • Scopus 0
  • ???jsp.display-item.citation.isi??? 0
social impact