: Extracellular vesicles (EVs) are membrane-bound particles released by all cells under physiological and pathological conditions. EVs constitute a potential tool to unravel cell-specific pathophysiological mechanisms at the root of disease states and retain the potential to act as biomarkers for cardiac diseases. By being able to carry bioactive cargo (such as proteins and miRNAs), EVs harness great potential as accessible "liquid biopsies", given their ability to reflect the state of their cell of origin. Cardiomyopathies encompass a variety of myocardial disorders associated with mechanical, functional and/or electric dysfunction. These diseases exhibit different phenotypes, including inappropriate ventricular hypertrophy, dilatation, scarring, fibro-fatty replacement, dysfunction, and may stem from multiple aetiologies, most often genetic. Thus, the aims of this narrative review are to summarize the current knowledge on EVs and cardiomyopathies (e.g., hypertrophic, dilated and arrhythmogenic), to elucidate the potential role of EVs in the paracrine cell-to-cell communication among cardiac tissue compartments, in aiding the diagnosis of the diverse subtypes of cardiomyopathies in a minimally invasive manner, and finally to address whether certain molecular and phenotypical characteristics of EVs may correlate with cardiomyopathy disease phenotype and severity.

Extracellular vesicles in cardiomyopathies: A narrative review / A.S. Rizzuto, A. Faggiano, C. Macchi, S. Carugo, C. Perrino, M. Ruscica. - In: HELIYON. - ISSN 2405-8440. - 10:1(2024 Jan 15), pp. e23765.1-e23765.12. [10.1016/j.heliyon.2023.e23765]

Extracellular vesicles in cardiomyopathies: A narrative review

A.S. Rizzuto
Co-primo
Conceptualization
;
A. Faggiano
Co-primo
Writing – Original Draft Preparation
;
C. Macchi
Methodology
;
S. Carugo
Writing – Review & Editing
;
M. Ruscica
Ultimo
Writing – Original Draft Preparation
2024

Abstract

: Extracellular vesicles (EVs) are membrane-bound particles released by all cells under physiological and pathological conditions. EVs constitute a potential tool to unravel cell-specific pathophysiological mechanisms at the root of disease states and retain the potential to act as biomarkers for cardiac diseases. By being able to carry bioactive cargo (such as proteins and miRNAs), EVs harness great potential as accessible "liquid biopsies", given their ability to reflect the state of their cell of origin. Cardiomyopathies encompass a variety of myocardial disorders associated with mechanical, functional and/or electric dysfunction. These diseases exhibit different phenotypes, including inappropriate ventricular hypertrophy, dilatation, scarring, fibro-fatty replacement, dysfunction, and may stem from multiple aetiologies, most often genetic. Thus, the aims of this narrative review are to summarize the current knowledge on EVs and cardiomyopathies (e.g., hypertrophic, dilated and arrhythmogenic), to elucidate the potential role of EVs in the paracrine cell-to-cell communication among cardiac tissue compartments, in aiding the diagnosis of the diverse subtypes of cardiomyopathies in a minimally invasive manner, and finally to address whether certain molecular and phenotypical characteristics of EVs may correlate with cardiomyopathy disease phenotype and severity.
Arrhythmogenic cardiomyopathy; Cardiomyopathies; Dilated cardiomyopathy; Extracellular vesicles; Hypertrophic cardiomyopathy
Settore MED/04 - Patologia Generale
Settore MED/11 - Malattie dell'Apparato Cardiovascolare
   EXTRAcellular Vesicles to Unravel Heart Failure Molecular and Clinical Phenotypes (EXTRAHF)
   EXTRAHF
   MINISTERO DELL'UNIVERSITA' E DELLA RICERCA
   2022ZPS49L_002
15-gen-2024
Article (author)
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/2434/1023349
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