Biocompatible and resorbable polylactic acid (PLA) derived polymers are used for clinical applications. Antioxidant vitamin E (Vit.E) and vitamin E acetate (Vit.E Ac), a Vit.E commercial analog, were added to PLA during films preparation. Wettability, protein adsorption analysis, platelet adhesion and whole blood coagulation experiments highlighted that Vit.E incorporation improved PLA hemocompatibility. NMR analysis showed that Vit.E and Vit.E Ac blending differentially altered PLA polymer organization with Vit.E leading to the formation of microcavities, as observed by SEM analysis, while reducing surface hydrophobicity.
Poly (D,L) lactic acid blending with vitamin e increases polymer hemocompatibility: An hydrophilic effect / F. Reno', G. Paul, M. Rizzi, G. Gatti, L. Marchese. - In: JOURNAL OF APPLIED POLYMER SCIENCE. - ISSN 0021-8995. - 129:3(2013), pp. 1527-1533. [10.1002/app.38841]
Poly (D,L) lactic acid blending with vitamin e increases polymer hemocompatibility: An hydrophilic effect
F. Reno'
Primo
;M. Rizzi;
2013
Abstract
Biocompatible and resorbable polylactic acid (PLA) derived polymers are used for clinical applications. Antioxidant vitamin E (Vit.E) and vitamin E acetate (Vit.E Ac), a Vit.E commercial analog, were added to PLA during films preparation. Wettability, protein adsorption analysis, platelet adhesion and whole blood coagulation experiments highlighted that Vit.E incorporation improved PLA hemocompatibility. NMR analysis showed that Vit.E and Vit.E Ac blending differentially altered PLA polymer organization with Vit.E leading to the formation of microcavities, as observed by SEM analysis, while reducing surface hydrophobicity.
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