Organically modified mesoporous silica nanoparticles (MSNs) containing rose bengal (RB), a xanthene dye, were successfully synthesized. RB-modified MSNs have shown a relevant photostability and a high efficiency in the photoproduction and delivery of singlet oxygen ((1)O2), which is particularly promising for photodynamic therapy (PDT) applications. In vitro tests have evidenced that RB-MSNs are able to reduce cell proliferation in one of the most aggressive skin cancer types (SK-MEL-28) after green-light irradiation.
An efficient rose bengal based nanoplatform for photodynamic therapy / E. Gianotti, B. Martins Estevão, F. Cucinotta, N. Hioka, M. Rizzi, F. Reno', L. Marchese. - In: CHEMISTRY-A EUROPEAN JOURNAL. - ISSN 0947-6539. - 20:35(2014), pp. 10921-10925. (Intervento presentato al convegno A cluster of articles from speakers attending the 5th EuCheMS Chemistry Congress : August 25 tenutosi a Istanbul nel 2014) [10.1002/chem.201404296].
An efficient rose bengal based nanoplatform for photodynamic therapy
F. Reno'Penultimo
;
2014
Abstract
Organically modified mesoporous silica nanoparticles (MSNs) containing rose bengal (RB), a xanthene dye, were successfully synthesized. RB-modified MSNs have shown a relevant photostability and a high efficiency in the photoproduction and delivery of singlet oxygen ((1)O2), which is particularly promising for photodynamic therapy (PDT) applications. In vitro tests have evidenced that RB-MSNs are able to reduce cell proliferation in one of the most aggressive skin cancer types (SK-MEL-28) after green-light irradiation.
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