Organically modified mesoporous silica nanoparticles (MSNs) containing rose bengal (RB), a xanthene dye, were successfully synthesized. RB-modified MSNs have shown a relevant photostability and a high efficiency in the photoproduction and delivery of singlet oxygen ((1)O2), which is particularly promising for photodynamic therapy (PDT) applications. In vitro tests have evidenced that RB-MSNs are able to reduce cell proliferation in one of the most aggressive skin cancer types (SK-MEL-28) after green-light irradiation.

An efficient rose bengal based nanoplatform for photodynamic therapy / E. Gianotti, B. Martins Estevão, F. Cucinotta, N. Hioka, M. Rizzi, F. Reno', L. Marchese. - In: CHEMISTRY-A EUROPEAN JOURNAL. - ISSN 0947-6539. - 20:35(2014), pp. 10921-10925. (Intervento presentato al convegno A cluster of articles from speakers attending the 5th EuCheMS Chemistry Congress : August 25 tenutosi a Istanbul nel 2014) [10.1002/chem.201404296].

An efficient rose bengal based nanoplatform for photodynamic therapy

F. Reno'
Penultimo
;
2014

Abstract

Organically modified mesoporous silica nanoparticles (MSNs) containing rose bengal (RB), a xanthene dye, were successfully synthesized. RB-modified MSNs have shown a relevant photostability and a high efficiency in the photoproduction and delivery of singlet oxygen ((1)O2), which is particularly promising for photodynamic therapy (PDT) applications. In vitro tests have evidenced that RB-MSNs are able to reduce cell proliferation in one of the most aggressive skin cancer types (SK-MEL-28) after green-light irradiation.
cytotoxicity; mesoporous silica nanoparticles; photodynamic therapy; Rose Bengal; singlet oxygen;
Settore BIO/16 - Anatomia Umana
2014
12-ago-2014
Article (author)
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/2434/1021975
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